Application of theaflavin as synergist of antifungal medicine
An antifungal drug, theaflavin technology, applied in the field of medicine, can solve the problems of no fungal disease, no antifungal effect, etc., and achieve the effects of improving the antifungal effect, saving medical expenses, and reducing the dosage of drugs
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Embodiment 1
[0006] Example 1: Effects of theaflavin and fluconazole in combination on different clinical fungal strains
[0007] Materials and methods
[0008] 1. Test drug:
[0009] Theaflavins: Wuhan Yuancheng Technology Development Co., Ltd.
[0010] Fluconazole injection: Pfizer Pharmaceutical Co., Ltd., batch number 9167802.
[0011] Dimethyl sulfoxide: Shanghai Shiyi Biotechnology Co., Ltd.
[0012] Theaflavin is made into solution with dimethyl sulfoxide, the concentration is 6.4mg / ml. All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.
[0013] 2. Strains:
[0014] Clinical strains: drug-resistant Candida albicans, including five strains 103, 17, 18, 38, and 0710448, and Candida tropicalis, including five strains 409, 936, 422, 0710453, and 0710087, all provided by the Mycology Department of Shanghai Changhai Hospital. Clinical samples fr...
Embodiment 2
[0043] Example 2: Combination of theaflavins and other azole antifungal drugs
[0044] Materials and methods
[0045] 1. Drugs
[0046] Itraconazole: Provided by the School of Pharmacy, Second Military Medical University
[0047] Ketoconazole: Provided by the School of Pharmacy, Second Military Medical University
[0048] Miconazole: Provided by the School of Pharmacy, Second Military Medical University
[0049] Itraconazole, ketoconazole and miconazole dimethyl sulfoxide were formulated to 6.4 mg / ml, theaflavins were formulated to 6.4 mg / ml with dimethyl sulfoxide, and each reagent was stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.
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