The present invention relates to a kind of new micelles of camptothecin and the pesticide obtained by compounding the micelles with other pesticides, as well as the preparation method. The present invention also relates to a specific compound, its preparation and its use in pesticides. use. The camptothecin micelles of the present invention are prepared by dissolving mPEG2000‑COOH in dry dichloromethane, and then adding camptothecin, 4‑dimethylaminopyridine, and N,N‑diisopropylcarbodiethylene Amine, after the reaction is completed, the organic phase is dried, filtered, distilled and spin-dried to obtain a crude product, which is purified and added to DMSO, and camptothecin nanomicelles are obtained by dialysis. The acetamiprid @CPT‑mPEG2000 micelle formed by wrapping acetamiprid of the present invention has better water solubility than camptothecin, and its poisonous activity is stronger than that of camptothecin.