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A kind of medicine for killing agricultural pests and its preparation method and application

A pesticide and application technology, applied to the field of medicine for killing agricultural pests and its preparation and application, can solve the problems of single mode of action, limited application of camptothecin, poor solubility of camptothecin, etc.

Inactive Publication Date: 2017-12-12
LANZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a potential insecticidal active substance, camptothecin has disadvantages such as poor solubility, easy opening of the camptothecin lactone ring and loss of activity, and a single mode of action, which greatly limits the application of camptothecin in pesticides.
How to improve the poor solubility of camptothecin, solve the problem that the camptothecin lactone ring is easy to open and lose activity, and further obtain pesticides with better poisoning effect is a major issue in this field

Method used

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  • A kind of medicine for killing agricultural pests and its preparation method and application
  • A kind of medicine for killing agricultural pests and its preparation method and application
  • A kind of medicine for killing agricultural pests and its preparation method and application

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Embodiment 4

[0048] Example 4: Calculation of co-toxicity coefficient: Toxicity evaluation adopts Sun Yunpei method (Sun Y.P., et al . Journal of Economic Entomology , 1960, 53 : 887-892), calculate the co-toxicity coefficient (co-toxicity coefficient, CTC), and use the CTC value to evaluate the joint toxicity of camptothecin and acetamiprid. CTC value120 means synergistic effect, between 80~120 means additive effect, and CTC value ≥200 means significant synergistic effect. Its calculation method is as follows:

[0049] 1) Calculation of toxicity index (TI)

[0050]

[0051] 2) Calculation of the actual toxicity index (ATI) of the mixture (m)

[0052]

[0053] 3) Calculation of the theoretical toxicity index (TTI) of the mixture (m)

[0054]

[0055] 4) Calculation of co-toxicity coefficient (CTC)

[0056]

[0057] See Table 5 for the co-toxicity coefficients of acetamiprid@CPT-PEG2000 micelles on three species of insects.

[0058]

[0059] According to the biologica...

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Abstract

The present invention relates to a kind of new micelles of camptothecin and the pesticide obtained by compounding the micelles with other pesticides, as well as the preparation method. The present invention also relates to a specific compound, its preparation and its use in pesticides. use. The camptothecin micelles of the present invention are prepared by dissolving mPEG2000‑COOH in dry dichloromethane, and then adding camptothecin, 4‑dimethylaminopyridine, and N,N‑diisopropylcarbodiethylene Amine, after the reaction is completed, the organic phase is dried, filtered, distilled and spin-dried to obtain a crude product, which is purified and added to DMSO, and camptothecin nanomicelles are obtained by dialysis. The acetamiprid @CPT‑mPEG2000 micelle formed by wrapping acetamiprid of the present invention has better water solubility than camptothecin, and its poisonous activity is stronger than that of camptothecin.

Description

technical field [0001] The present invention relates to a medicine for killing agricultural pests and its preparation method and use, specifically a new micelle of camptothecin and a pesticide obtained by compounding the micelle with other pesticides, as well as a preparation method. The invention also relates to a specific compound, its preparation and use in pesticides. Background technique [0002] Pesticides can generally be divided into chemical pesticides and biological pesticides. At present, chemical pesticides are mainly used in my country. However, chemical pesticides are highly toxic and pollute the environment more and more seriously. Moreover, due to long-term, single use or abuse of pesticides, it is very easy for pests to develop resistance to pesticides, and even develop cross-resistance and Multiple resistance (Hilder V.A., et al . Crop Protection ,1999, 18 : 177-191). According to statistics, during the century from 1910 to 2010, the number of drug-res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/00C08G65/48A01N47/40A01N43/90A01P5/00A01P7/02A01P7/04
Inventor 刘映前张智军余海涛张绍勇陈安良吴小兵宋子龙朱高翔
Owner LANZHOU UNIVERSITY
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