Pesticide for killing agricultural pests as well as preparation method and application of pesticide

A technology for agricultural pests and nano-drugs, applied in the fields of botanical equipment and methods, chemicals for biological control, pesticides, etc., which can solve the problems of single mode of action, poor solubility of camptothecin, and loss of activity.

Inactive Publication Date: 2016-02-03
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a potential insecticidal active substance, camptothecin has disadvantages such as poor solubility, easy opening of the camptothecin lactone ring and loss of activity, and a single mode of action, which greatly limits the application of camptothecin in pesticides.
How to improve the poor solubility of camptothecin, solve the problem that the camptothecin lactone ring is easy to open and lose activity, and further obtain pesticides with better poisoning effect is a major issue in this field

Method used

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  • Pesticide for killing agricultural pests as well as preparation method and application of pesticide
  • Pesticide for killing agricultural pests as well as preparation method and application of pesticide
  • Pesticide for killing agricultural pests as well as preparation method and application of pesticide

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Experimental program
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Effect test

Embodiment 4

[0047] Embodiment 4: Calculation of co-toxicity coefficient: Toxicity evaluation adopts Sun Yunpei method (SunY.P., etal . Journal of Economic Entomology ,1960, 53 :887-892), calculate the co-toxicity coefficient (co-toxicity coefficient, CTC), and use the CTC value to evaluate the combined toxicity of camptothecin and acetamiprid. CTC value120 means synergistic effect, between 80~120 means additive effect, and CTC value ≥200 means significant synergistic effect. Its calculation method is as follows:

[0048] 1) Calculation of toxicity index (TI)

[0049]

[0050] 2) Calculation of the actual toxicity index (ATI) of the mixture (m)

[0051]

[0052] 3) Calculation of the theoretical toxicity index (TTI) of the mixture (m)

[0053]

[0054] 4) Calculation of co-toxicity coefficient (CTC)

[0055]

[0056] See Table 5 for the co-toxicity coefficients of acetamiprid CPT-PEG2000 micelles on three species of test insects.

[0057]

[0058] According to the bi...

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Abstract

The invention relates to a novel camptothecin micelle, a pesticide obtained by combining the camptothecin micelle with another pesticide, and preparation methods, and further relates to a specific compound, a preparation method of the specific compound, and application of the specific compound in pesticides. The preparation method of the camptothecin micelle comprises the following steps: dissolving mPEG2000-COOH in dry methylene chloride, and then sequentially adding camptothecin, 4-dimethylamino pyridine and N,N-diisopropylcarbodiimide for a reaction; after the reaction is finished, carrying out organic phase drying treatment, filtration, distillation and spin drying to obtain a crude product; carrying out purification, adding the purified product into DMSO, and carrying out dialysis to obtain the camptothecin nano-micelle. Compared with camptothecin, the acetamiprid-coated CPT-mPEG2000 micelle formed by coating acetamiprid is higher in water solubility and toxic activity.

Description

technical field [0001] The present invention relates to a medicine for killing agricultural pests and its preparation method and use, specifically a new micelle of camptothecin and a pesticide obtained by compounding the micelle with other pesticides, as well as a preparation method. The invention also relates to a specific compound, its preparation and use in pesticides. Background technique [0002] Pesticides can generally be divided into chemical pesticides and biological pesticides. At present, chemical pesticides are mainly used in my country. However, chemical pesticides are highly toxic and pollute the environment more and more seriously. Moreover, due to long-term, single use or abuse of pesticides, it is very easy for pests to develop resistance to pesticides, and even develop cross-resistance and Multiple resistance (HilderV.A., etal . Crop Protection ,1999, 18 :177-191). According to statistics, during the century from 1910 to 2010, the number of drug-resist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/00C08G65/48A01N47/40A01N43/90A01P5/00A01P7/02A01P7/04
Inventor 刘映前张智军余海涛张绍勇陈安良吴小兵宋子龙朱高翔
Owner LANZHOU UNIVERSITY
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