44 results about "Sodium houttuyfonate" patented technology

The invention discloses a new sodium houttuyfonate injection and a preparation method thereof, which are used for treating milk cow mastitis and belong to the technical field of animal remedies. The sodium houttuyfonate injection comprises the following components in percentage by weight: 0.01 to 10 percent of new sodium houttuyfonate, 0.1 to 50 percent of solubilizing agent, 0.1 to 50 percent of pH modifying agent, and 0.01 to 0.5 percent of antioxidant. The preparation method comprises the following steps of: fully mixing the new sodium houttuyfonate with the solubilizing agent, and then uniformly grinding the mixture; adding aqueous solution of the antioxidant to adjust the pH to be 4.5 to 6.5; adding activated carbon to remove pyrogen; decarburizing and filtering the mixture; filtering the mixture for degermation by using 0.22 mum microporous filter membrane terminal; and performing nitrogen-filling and sub-package, capping sealing, and sterilized packaging to obtain the injection. The new sodium houttuyfonate injection has a simple formula, safe quality and high stability; and the preparation process is simple and feasible, is convenient to operate, is low in cost, is suitable for industrial production, and has an extensive prospect.

The invention discloses a tildipirosin composition and applications thereof in treating or preventing poultry respiratory tract diseases. The tildipirosin composition comprises tildipirosin/pharmaceutically-acceptable salts of tildipirosin, sodium houttuyfonate, and a pharmaceutically-acceptable carrier; and can be made into different oral dosage forms such as soluble powder, granule, oral liquid, premix, and the like. The provided tildipirosin composition has the characteristics of wide distribution in poultry body, large apparent volume of distribution, long half life, slow elimination, little using amount, and good curative effect, and has a good curative effect on poultry respiratory tract diseases caused by bacteria and mycoplasma.

The invention provides a skin bacteriostatic composition which has no irritation to skins and has durable bacteriostatic and antibacterial action. According to the skin bacteriostatic composition, allicin, sodium houttuyfonate, elaterin, rhizoma dioscoreae septemlobae extract and radix astragali seu hedysari extracting liquid which have bacteriostatic and antibacterial action are taken as bacteriostatic and antibacterial main components, camellia oil with antibacterial activity is added, and vitamin C and hyaluronic acid are taken as main skin heat-insulating nutrition components. The skin bacteriostatic composition can be directly applied on the surface of skin, pH value is appropriate, the salinity and water-moisture balance of the skin can be regulated, and the skin bacteriostatic composition has no irritation to the skin and difficultly causes allergic reaction.

A medicine in the form of capsules for treating cough with durable effect is prepared through extracting active components from fresh mango fruit, proportional mixing with sodium houttuyfonate and chlorpheniramine, granulating and loading in capsules.

A compound medicine in the form of tablet, capsule or softgel is prepared from the dried extract of mango leaf, sodium houttuyfonate and chlorphenamine maleate. Its quality control method features that a thin-layer chromatography is used to identify said three components and an efficient liquid-phase chromatographe is used to measure their contents.

The invention belongs to the technical field of veterinary drug preparations, in particular to temperature-sensitive type gel for curing endometritis of livestock and a preparation method for the temperature-sensitive type gel. The temperature-sensitive type gel comprises the following main drug: one of 5 to 10 percent of ofloxacin, 1 to 2 percent of sodium new houtluyfonate, 1 to 2 percent of sodium houttuyfonate, 5 to 20 percent of sulfadiazine sodium, 5 to 20 percent of sulfamonomethoxine sodium and 10 to 20 percent of lincomycin hydrochloride, the following auxiliary materials: 10 to 30 percent of gel matrix, 1 to 2 percent of release rate regulator, 0.1 to 0.5 percent of antioxygen and 0.5 percent of acetic acid, and balance of water for injection in weight percentage. By fully utilizing the characteristics of good flowability, long resistance time, slow drug release and lasting and stable drug effect of the temperature-sensitive type gel disclosed by the invention, the endometritis of the female livestock is effectively cured, and the curative effect is thorough; meanwhile, the labor strength of a cultivation worker is reduced; the temperature-sensitive type gel is more convenient in therapeutic use.

The invention relates to vein injection and its preparing method, which contains effective quantity of cosolvent, injected solvent or isoosmotic solution and excipient and pH conditioning agent can be added into if there is need.

The invention relates to the technical field of medicaments, in particular to novel application of sodium houttuyfonate as a synergist of an antifungal medicament. The antifungal medicament is an azole or polyene antifungal medicament; and 1 to 16mu g of sodium houttuyfonate is added into each 1ml of antifungal medicament. Experiments prove that: when the sodium houttuyfonate is combined with the antifungal medicament such as fluconazole, ketoconazole, miconazole or amphotercin B, and the like, the treatment effect of the sodium houttuyfonate on superficial or deep fungal infection can be ensured under the condition of reducing the dosage and the sodium houttuyfonate can make the antifungal medicament recover the effect on medicament-resistant fungi, so the sodium houttuyfonate can be used as the synergist of the antifungal medicament. The sodium houttuyfonate serving as the synergist of the antifungal medicament can reduce the dosage of the azole or polyene antifungal medicament so as to reduce the toxic and side effects of the medicament; and particularly, the sodium houttuyfonate makes the antifungal medicament recover the effect on the medicament-resistant fungi, effectively treats fungal infection, particularly medicament-resistant fungal infection, and has important clinical application value.

The invention discloses skin-care cream and a preparation method thereof. The skin-care cream disclosed by the invention is prepared from ester mangiferin, sodium houttuyfonate, muriatic berberine, artemisia vulgaris essential oil, orange peel extract, Guangxi sweet tea extract and succinic acid compounding ingredients; the skin-care cream is prepared by microencapsulating main components of the mangiferin and berberine. The skin-care cream prepared by the preparation method disclosed by the invention has the effects of resisting inflammation and bacteria, moisturizing and resisting ultraviolet, is easily absorbed by skin and can be used for preventing and treating skin acne as well as skin itching and redness caused by mosquito bites. The skin-care cream disclosed by the invention is mildin drug properties and is suitable for people with sensitive skin like child skin.

The invention discloses a full-function health maintenance conditioning instrument. The instrument comprises a closed box body with a door, a heating device, five-color lamps, a five-tone player, foot sole magnetic energy massage devices and negative ion generators. The instrument further comprises a video, an interphone, a temperature controller and herb purification health maintenance boxes which comprise plastic boxes and health maintenance raw materials. Multiple air holes are formed in the two ends of each plastic box, and the health maintenance raw material are composed of the tomatine, sodium houttuyfonate, the sea buckthorn flavone, the Kuding flavone, the gaultheria yunnansis oil and sublimation agents. The negative ion generators are movable and replaceable negative ion generators and installed on the wall A, the wall B and the wall C of the box body respectively. The interphone and the temperature controller are installed on the wall C of the box body. The problems that in the market, a health maintenance device is single in function and poor in health maintenance effect are solved, and the health maintenance condition instrument integrates multiple functions, comprehensively improves the immunity of the human body and the health maintenance effect and is more convenient to use for a user.

The invention relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a test method thereof. The expansive suppository comprises sodium houttuyfonate-containing matrix and an expansive carrier; in the sodium houttuyfonate-containing matrix, acid particles and alkaline particles generate carbon dioxide when meeting water, so as to foam, and in combination with the expansive action of the expansive carrier, sodium houttuyfonate can reach vaginal deep site and fold site to improve the drug action range; ascorbic acid in acid particles has an antioxidant effect to improve the stability of the suppository; buffer salt particles in the sodium houttuyfonate-containing matrix provide an appropriate pH environment which is in favor of the complete effervescence of the suppository and improves the bioavailability of sodium houttuyfonate in the suppository; the hollow effervescent vaginal suppository seals the drug-containing layer in the matrix hollow cavity, so as to improve the stability of the expansive suppository; the sodium houttuyfonate vaginal expansive suppository adopts six original advanced techniques, and has the beneficial effects of prevention of medicinal liquid from flowing out, high stability, lasting therapeutic effect, prevention of secondary infection, and so on.

The invention provides sodium houttuyfonate dispersible tablets. The sodium houttuyfonate dispersible tablets are prepared by uniformly mixing coating micro-capsules of sodium houttuyfonate with other pharmaceutically acceptable adjuvant materials prior to tableting.

The invention discloses Application of sodium houttuyfonate in preparation of products for prevention and treatment of diabetic cardiopathy. Houttuyfonate sodium can be use for preparing product for preventing and treating diabetic heart disease, regulating myocardial energy metabolism disorder, and improving glycolipid metabolism abnormality. The invention has been proved by experiments that: (1)sodium houttuyfonate has preventive and therapeutic effects on diabetic heart disease and cardioprotective effects; (2) It can regulate the disturbance of myocardial energy metabolism; (3) It can reduce the increase of blood lipid caused by diabetes mellitus and has the effect of lowering blood glucose. It has good clinical application prospect in the prevention and treatment of diabetes-inducedcardiac injury, myocardial energy metabolism disorder, glucose and lipid metabolism abnormalities and so on.

The invention relates to a traditional Chinese veterinary medicine for treating avian respiratory infectious disease. In parts by weight, 100 parts of the traditional Chinese veterinary medicines comprise the following crude drugs: 0.3-0.5 part of calculus bovisfactitious, 0.1-0.3 part of venenumbufonis, 1-3 parts of scutellariabaicalensis extracts, 0.1-0.3 part of borneol, 15-20 parts of liquorice extracts, 5-10 parts of folium eucalypti, 0.2-0.6 part of sodium houttuyfonate, 2-8 parts of tween-80, 15-25 parts of cyclodextrin and the balance of sucrose powder with granularity of 100 mesh. The traditional Chinese veterinary medicine for treating avian respiratory infectious disease has the advantages of reliable curative effect, rapid action and low cost, and is convenient to use.

The invention provides application of sodium houttuyfonate to preparation of a medicament for treating heart failure and/or arrhythmia. The invention also provides application of the sodium houttuyfonate to preparation of a medicament for enhancing contractile force of ventricular myocytes. The sodium houttuyfonate increases L-type calcium current (Ica.L), and can improve myocardial systolic dysfunction caused by the reduction of sarcoplasmic reticulum Ca release when the heart failure is occurred. The sodium houttuyfonate blocks peak sodium current (Ina.p) and has the characteristics of class-I antiarrhythmic medicaments, and can also block late sodium current (INa.L) increased by the induction of congestin II (ATX-II) and has the potential of inhibiting the arrhythmia caused by the increment of the INa.L.

The invention belongs to the field of biomedical materials, and particularly discloses a polymer microneedle patch for treating acne and a preparation method of the polymer microneedle patch. The polymer microneedle patch is composed of a base and needle tips, the base is a cuboid, the needle tips are cones and are evenly distributed on the base, and the needle tips comprise bioactive high-molecular compounds, sodium houttuyfonate and erythromycin. Through the interaction between drugs and the bioactive high-molecular compounds, drug release can be effectively controlled, by combined use of the sodium houttuyfonate and the erythromycin, generation of drug resistance of propionibacterium acnes can be effectively prevented, the treatment effect of the acne is enhanced, meanwhile, the needle tips and the base are separated to achieve the effect that the drug-loaded needle tips are left in the skin, the drugs can achieve programmed release of the drugs, and the effect of treating the acne is further improved.

The invention relates to a compound medicine for preventing and treating porcine reproductive and respiratory syndrome, and belongs to the field of veterinary medicines. The compound medicine is an oral pharmaceutical preparation prepared from macrolide medicines special for animals, sodium houttuyfonate, mannatide and pharmaceutical adjuvants in a certain proportion. The medicine disclosed by the invention can be used for effectively treating acute-stage porcine reproductive and respiratory syndrome, rapidly relieving clinical symptoms of diseased pigs and improving survival rate.

The invention relates to a testing method of a compound Sijiqing Pian (tablet of folium ilicis chinensis extract). The testing method includes firstly, identifying the compound Sijiqing Pian; secondly, determining content of sodium houttuyfonate of the compound Sijiqing Pian by the steps of of preparing a reference solution, preparing a test sample solution, and determining, to be specific, injecting the reference solution and the test sample solution into a high performance liquid chromatograph by sucking to obtain a chromatogram and then calculating the content of sodium houttuyfonate according to the chromatogram, wherein, chromatographic conditions of the high-performance liquid chromatograph include taking octadecylsilane chemically bonded silica as a filler, taking a solution, containing acetonitrile, 0.01mol/L of tetrabutylammonium bromide and diethylamine of which the ratio being 30 : 40 : 0.028, as a mobile phase, setting the testing wavelength to be 283nm, and controlling thenumber of theoretical plates to be not lower than 3000 by calculating according to the peak of sodium houttuyfonate.

Houttuynin is the main extract in the volatile oil of Houttuynia cordata, and has excellent antibacterial, antiviral and anti-inflammatory effects, so the houttuynin can be widely applied to medicines. The chemical properties of the houttuynin are unstable, so the medical application of the houttuynin is limited, so it is necessary to carry out chemical modification to synthesize a series of new compounds reserving the original active structure in order to obtain a compound with high activity. Sodium houttuyfonate and its homologues octanoyl acetal sodium sulfite and sodium new houttuyfonate,which are used as raw materials, are chemically modified on the basis of reserving the active group carbonyl group to obtain novel compounds with high or extensive bioactivity, so the future studyingof houttuynin drugs is benefited. The invention discloses a method for synthesizing a series of houttuynin 1,4-butanediamine Schiff bases with different carbon chain lengths, and a copper complex thereof. The formula of the Schiff base is C4H8N2(CnH2n+1)2.

The invention provides an application of sodium houttuyfonate in preparation of a medicine for preventing and treating nervous system diseases taking a Kv7/M channel as a target spot, sodium houttuyfonate or any derivative of sodium houttuyfonate, or a natural, synthetic or semi-synthetic sodium houttuyfonate-containing mixture or a sodium houttuyfonate-containing composition of sodium houttuyfonate, and the sodium houttuyfonate or any derivative of sodium houttuyfonate has the effects of increasing the Kv7/M current, and changing the action mechanism of cell excitability obviously, the Kv7/M current can be used for preparing medicines for preventing, treating and assisting in treating nervous system diseases and symptoms, the action mechanism of obviously changing the cell excitability by increasing the Kv7/M current is never reported, and the action mechanism is completely different from the action mechanism of the existing medicine application of sodium houttuyfonate.