Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof

Abstract

The invention relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a test method thereof. The expansive suppository comprises sodium houttuyfonate-containing matrix and an expansive carrier; in the sodium houttuyfonate-containing matrix, acid particles and alkaline particles generate carbon dioxide when meeting water, so as to foam, and in combination with the expansive action of the expansive carrier, sodium houttuyfonate can reach vaginal deep site and fold site to improve the drug action range; ascorbic acid in acid particles has an antioxidant effect to improve the stability of the suppository; buffer salt particles in the sodium houttuyfonate-containing matrix provide an appropriate pH environment which is in favor of the complete effervescence of the suppository and improves the bioavailability of sodium houttuyfonate in the suppository; the hollow effervescent vaginal suppository seals the drug-containing layer in the matrix hollow cavity, so as to improve the stability of the expansive suppository; the sodium houttuyfonate vaginal expansive suppository adopts six original advanced techniques, and has the beneficial effects of prevention of medicinal liquid from flowing out, high stability, lasting therapeutic effect, prevention of secondary infection, and so on.

Description

Technical field [0001] The invention belongs to the field of vaginal suppositories, and particularly relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a detection method thereof. Background technique [0002] Houttuyfonate sodium is a white or almost white needle-like or scaly crystal, or crystalline powder; it has a slight odor and has a special fishy odor when it meets water; it is easily soluble in hot water, and slightly in water or ethanol. Soluble, almost insoluble in chloroform or benzene. Houttuyfonate sodium has a significant inhibitory effect on catarrhalis, influenza bacillus, pneumococcus, and Staphylococcus aureus, and has obvious antagonistic effects on inflammatory exudation and tissue edema in the early stage of inflammation, and inhibits inflammatory pain response. It is especially suitable for Treatment of cervical erosion. Because its structure is an adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it...

AI Technical Summary

Problems solved by technology

Because its structure is the adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it is relatively unstable. When it is affected by heat, light, humidity, etc., especially alkaline solution, it is easy to decompose into impurity compounds such as carbonyl and carboxyl. its curative effect

Existing houttuyfonate sodium suppositories have technical problems such as low dissolution rate, small area of ​​drug action, poor stability, and slow onset of action; common houttuyfonate sodium suppositories also have the disadvantages of being difficult to clean and easily polluting clothes; active ingredients and The human body contact surface is small, resulting in insufficient absorption, and technical problems such as not exerting the best curative effect of the formula

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