Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof

A technology of houttuyfonate sodium and vaginal expansive suppositories, which can be used in suppository delivery, pharmaceutical formulations, material inspection products, etc. It can solve the problems of easily polluted clothes, poor stability, and instability, so as to avoid secondary infection and overcome poor stability , the effect of increasing stability

Active Publication Date: 2014-05-14
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because its structure is the adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it is relatively unstable. When it is affected by heat, light, humidity, etc., especially alkaline solution, it is easy to decompose into impurity compounds such as carbonyl and carboxyl. its curative effect
Existing houttuyfonate sodium suppositories have technical problems such as low dissolution rate, small area of ​​drug action, poor stability, and slow onset of action; common houttuyfonate sodium suppositories also have the disadvantages of being difficult to clean and easily polluting clothes; active ingredients and The human body contact surface is small, resulting in insufficient absorption, and technical problems such as not exerting the best curative effect of the formula

Method used

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  • Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof
  • Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof
  • Sodium houttuyfonate vaginal expansive suppository and preparation method and test method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100]

[0101] Preparation:

[0102] 1) Preparation of drug-containing matrix:

[0103] a. Put methyl oleate, cocoa butter and hydrogenated cottonseed oil in a water bath to heat and melt to obtain a melt;

[0104] b. Add the houttuyfonate sodium to step a under stirring, and mix evenly to obtain a drug-containing matrix;

[0105] 2) Preparation of expansion suppository: pour the drug-containing matrix into the suppository mold, insert a cotton sliver, cool and shape, and make 100 spherical suppositories, each weighing about 3.6 g .

Embodiment 2

[0107]

[0108] Preparation:

[0109] 1) Preparation of drug-containing matrix:

[0110] a. The tallow fat and hydrogenated castor oil are heated and melted in a water bath to obtain a melt;

[0111] b. Grind ascorbic acid and houttuyfonate sodium together and mix them evenly to obtain acidic particles;

[0112] c. Grind the sodium bicarbonate and the sodium houttuyfonate together and mix them evenly to obtain alkaline particles;

[0113] d. Mix acidic particles and alkaline particles, and grind them evenly to obtain a mixture;

[0114] e. Mix the mixture of step d and the melt of step a uniformly to prepare a drug-containing matrix;

[0115] 2) Pour the drug-containing matrix into the suppository mold, insert the cotton sliver, and cool and shape to make 100 stick-shaped suppositories, each weighing about 4.4g.

Embodiment 3

[0117]

[0118] Preparation method: According to the method of Example 2, 100 bullet-shaped suppositories were made, each weighing about 3.2g.

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PUM

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Abstract

The invention relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a test method thereof. The expansive suppository comprises sodium houttuyfonate-containing matrix and an expansive carrier; in the sodium houttuyfonate-containing matrix, acid particles and alkaline particles generate carbon dioxide when meeting water, so as to foam, and in combination with the expansive action of the expansive carrier, sodium houttuyfonate can reach vaginal deep site and fold site to improve the drug action range; ascorbic acid in acid particles has an antioxidant effect to improve the stability of the suppository; buffer salt particles in the sodium houttuyfonate-containing matrix provide an appropriate pH environment which is in favor of the complete effervescence of the suppository and improves the bioavailability of sodium houttuyfonate in the suppository; the hollow effervescent vaginal suppository seals the drug-containing layer in the matrix hollow cavity, so as to improve the stability of the expansive suppository; the sodium houttuyfonate vaginal expansive suppository adopts six original advanced techniques, and has the beneficial effects of prevention of medicinal liquid from flowing out, high stability, lasting therapeutic effect, prevention of secondary infection, and so on.

Description

Technical field [0001] The invention belongs to the field of vaginal suppositories, and particularly relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a detection method thereof. Background technique [0002] Houttuyfonate sodium is a white or almost white needle-like or scaly crystal, or crystalline powder; it has a slight odor and has a special fishy odor when it meets water; it is easily soluble in hot water, and slightly in water or ethanol. Soluble, almost insoluble in chloroform or benzene. Houttuyfonate sodium has a significant inhibitory effect on catarrhalis, influenza bacillus, pneumococcus, and Staphylococcus aureus, and has obvious antagonistic effects on inflammatory exudation and tissue edema in the early stage of inflammation, and inhibits inflammatory pain response. It is especially suitable for Treatment of cervical erosion. Because its structure is an adduct of dicarbonyl and aldehyde carbonyl and sodium bisulfite, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/185A61K47/22A61P15/00G01N33/15G01N5/04
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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