Compound chloramphenicol vaginal swelling suppository, as well as preparation method and detection method thereof

Abstract

The invention provides a compound chloramphenicol vaginal swelling suppository, as well as a preparation method and a detection method thereof. The swelling suppository comprises a drug-containing matrix formed by an active component and a matrix, and a swelling vector, wherein the active component comprises chloramphenicol, boric acid, vitamin A and vitamin D2; the drug-containing matrix also comprises octadecyl sodium fumarate, sucrose monopalmitate and polyoxyethylenealiphatic alcohol ether; the layer out of the core of the swelling suppository is coated with an ointment layer. The compound chloramphenicol vaginal swelling suppository has the beneficial effects of high stability and small vaginal irritation, adopts seven original advanced technologies, has the beneficial effects of preventing a liquid medicine from overflowing, preventing secondary infection and the like, and is quick in response and long in curative effect.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a compound chloramphenicol vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Chloramphenicol, the chemical name is D-threo-(-)-N-[α-(hydroxymethyl)-β-hydroxy-p-nitrophenethyl]-2,2-dichloroacetamide, which is White to slightly yellow-green needle-shaped, long-sheet crystal or crystalline powder; bitter; soluble in methanol, ethanol, etc., slightly soluble in water. [0003] Boric acid is colorless yellowish pearl luster crystal or white loose powder, with a greasy feel; odorless; weakly acidic reaction in aqueous solution; easily soluble in boiling water, boiling ethanol or glycerin, and soluble in water or ethanol. [0004] Vitamin A is a light yellow oil solution or a mixture of crystals and oil; odorless, easily oxidized in the air, and easily deteriorated when exposed to light; soluble in chloroform, ether...

AI Technical Summary

Problems solved by technology

[0006] Suppositories made of chloramphenicol, boric acid, vitamin A and vitamin D2 as active ingredients and semi-synthetic fatty acid glycerides are included in the third volume of the national standard of chemical medicine; clinically used to treat leucorrhea caused by cervicitis, vaginal discharge Burning pain and other diseases; the suppository has been widely used, but because the active ingredients in the suppository are poor in water solubility and unstable in nature, which affects the bioavailability and stability of the suppository, and then affects the curative effect of the suppository; It can cause irritation in the vagina; in addition, ordinary compound chloramphenicol suppositories are not easy to clean and easily contaminate clothes; the active ingredient has a small contact surface with the human body, resulting in insufficient absorption and failure to exert the best curative effect of the prescription.

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