31 results about "Sodium fumarate" patented technology

The invention discloses a glass fiber based molecular sieve / aluminum fumaric acid MOF composite adsorbent as well as a synthesis method and application thereof, and belongs to the technical field of adsorbents for rotary dehumidifiers. The synthesis method comprises the following steps: preparing a molecular sieve, sodium fumarate, a film-forming agent, a polymer thickening agent and deionized water into uniform dispersion liquid; immersing glass fiber paper into the dispersion liquid, and drying to obtain glass fiber paper containing molecular sieve / sodium fumarate; the preparation method comprises the following steps: preparing a mixed solution from an aluminum salt, ethanol and deionized water, immersing glass fiber paper containing molecular sieve / sodium fumarate into the mixed solution, carrying out an in-situ crystallization reaction, washing with water, and drying to obtain the glass fiber based molecular sieve / aluminum fumaric acid MOF composite adsorbent. According to the synthesis method, the traditional molecular sieve and the aluminum fumaric acid MOF are compounded to form the composite adsorbent, the requirements of low-temperature desorption and high adsorption capacity can be met at the same time, and modulation of the adsorption isotherm between the molecular sieve and the aluminum fumaric acid MOF can be achieved by adjusting the ratio of the molecular sieve to the aluminum fumaric acid MOF.

The invention discloses a preparation method of a brexpiprazole tablet, and belongs to the field of pharmacy, and the brexpiprazole tablet comprises the following components: brexpiprazole, lactose, corn starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, hydroxypropyl cellulose and sodium stearyl fumarate. By controlling specific parameters in combination with operation steps in the preparation method, the medicine with good product quality can be produced, the product quality is stable, and the content of related substances is low.

The invention discloses a solid windshield washer fluid and a preparation method thereof, the solid windshield washer fluid comprises the following raw materials by weight: 45-55 parts of an acid source, 25-40 parts of sodium carbonate, 9-10 parts of a surfactant, 2.5-3.5 parts of a corrosion inhibitor, 1.5-2.5 parts of an antifoaming agent, and 3.5-4 parts of a builder; the washing assistant comprises sodium pyrophosphate, and the washing assistant further comprises one or more of hydroxypropyl methylcellulose and sodium stearyl fumarate. The preparation method of the solid windshield washer fluid comprises three steps of mixing, tabletting and slicing. The solid windshield washer fluid provided by the invention can achieve the effects of being good in cleaning effect, excellent in spreading performance and capable of protecting a windscreen wiper.

To provide a tablet composition excellent in slow solubility and reduced in adhesion to an object to be washed.SOLUTION: The composition comprises (A) at least one selected from the group consisting of calcium sulfate, calcium carbonate, calcium hydrogenphosphate and aluminum silicate, and (B) at least two selected from the group consisting of (B1) ingredient and (B2) ingredient, wherein the (B1) ingredient is at least one selected from the group consisting of carnauba wax, rice bran wax, hydrogenated oil, sucrose fatty ester, sunflower wax, candelilla wax and rose wax, and the (B2) ingredient is at least one selected from the group consisting of magnesium stearate, calcium stearate, sodium stearyl fumarate and sodium lauryl sulfate.SELECTED DRAWING: Figure 1

The invention relates to a fresh-cut lotus root fresh-keeping method and a compound fresh-keeping agent and a fresh-keeping product thereof, and belongs to the technical field of food processing and fresh keeping. According to the method, in order to solve the problem of quality deterioration caused by easy enzymatic browning and microbial contamination in the storage process of the fresh-cut lotus roots, the fresh-cut lotus root slices are sequentially subjected to active electrolyzed water soaking treatment and sodium fumarate solution soaking treatment in a synergistic manner, so that the browning key enzyme activity and microbial growth are effectively inhibited. The method is simple and convenient to operate, can obviously delay the browning process of the fresh-cut lotus roots and reduce the microbial load, so that the appearance color and sensory quality of the fresh-cut lotus roots are maintained, the shelf life is prolonged, and the method is suitable for postharvest fresh-keeping treatment of the fresh-cut lotus roots.

This invention discloses a controlled-release nitrogen fertilizer containing organic acid salt signaling substances. From the inside out, it comprises urea particles, a cross-linked material-trace element mixture, molten urea, and a bio-based polyurethane coating material. The cross-linked material-trace element mixture is a porous cross-linked material loaded with trace elements. The porous cross-linked material is obtained by cross-linking alginic acid and organic acid salts through a cross-linking agent. The organic acid salts are selected from at least one of sodium citrate, sodium fumarate, sodium maleate, sodium malonate, and sodium succinate. The trace elements are selected from at least one of zinc, cobalt, molybdenum, and iron. This invention, through alginic acid-organic acid salt cross-linking, precise loading of trace elements, and multi-layer coating technology, produces a novel controlled-release fertilizer that combines pH responsiveness, environmental resistance, and high nutrient utilization. Nutrient release can be dynamically controlled according to soil pH and crop needs, reducing nutrient loss and environmental pollution, meeting the needs of green agriculture development, and providing an innovative solution for improving fertilizer utilization and crop yield.

The present invention relates to a capsule formulation comprising migalastat hydrochloride and at least one lubricant, wherein the lubricant is sodium stearyl fumarate. The process is simple, rapid, cost effective, time-saving and industrially convenient process and is created to eliminate the disadvantages of active ingredient.

Composition for air polishing the surface of hard dental tissues. The present invention relates to a composition (1) for air polishing the surface of hard dental tissues, comprising at least: - a first abrasive powder suitable for polishing hard dental tissues, the first powder being present in the composition at a mass content of between 90% and 99.5%, and - a second powder of at least one anti-caking agent, different from the first powder, comprising at least one sodium stearyl fumarate powder present in the composition at a mass content of between 0.5% and 5% and having a D50 particle size of between 5 µm and 200 µm, for example between 10 µm and 80 µm, at least 50% of the constituent particles of the second powder having a smallest dimension greater than 100 nm. Figure for the abstract: Fig. 1.

The present invention relates to a composition (1) for air-polishing the surface of hard dental tissues, comprising at least: a first abrasive powder capable of polishing hard dental tissues, the first powder being present in the composition in a weight content of between 90% and 99.5%, and a second powder of at least one anti-caking agent, different from the first powder, comprising at least one sodium stearyl fumarate powder present, in the composition, in a weight content of between 0.5% and 5% and having a particle size D50 of between 5 μm and 200 μm, for example between 10 μm and 80 μm, at least 50% of the constituent particles of the second powder having a smallest dimension greater than 100 nm.

This invention discloses a guanifacine hydrochloride sustained-release tablet and its preparation method. The method includes placing a granulated / mixed, tableted guanifacine hydrochloride pharmaceutical composition into a hot air device for drying. The hot air device is selected from a coating machine or an oven, and the hot air temperature ranges from 30 to 70°C. After drying, the resulting guanifacine hydrochloride sustained-release tablet has a moisture content ≤4.0% by weight, preferably ≤3.5% by weight. The guanifacine hydrochloride pharmaceutical composition contains guanifacine hydrochloride, lactose, microcrystalline cellulose, hydroxypropyl methylcellulose, methacrylate copolymer, fumaric acid, glyceryl behenate, sodium stearate fumarate, and micronized silica gel. This hot air drying process effectively controls the total impurities of the guanifacine hydrochloride sustained-release tablets to ≤1.0% and the single impurities to ≤0.1%. This process improves the safety and stability of the drug, is easy to operate, and is suitable for commercial production.

The present disclosure discloses a homogeneous pharmaceutical excipient sodium stearyl fumarate with flaky structure and preparation method thereof, which belongs to the field of pharmaceutical excipient refining technology. The method of the present disclosure includes: heating and dissolving sodium stearyl fumarate to be treated in an ethanol solution and filtering to remove impurities, then adding crystal seeds for recrystallization. The crystallized sodium stearyl fumarate with flaky structure has narrow particle size distribution, average particle size of 5-15 μm, intact flaky structure, good uniformity and purity up to 99.6% or more, and it is not easy-caking and can keep the powder state for a long time.

The invention provides a compound omeprazole capsule and a preparation method thereof. The compound omeprazole capsule is prepared from 20 mg of omeprazole, 1100 mg of sodium bicarbonate, 25-35 mg of croscarmellose sodium and 5-15 mg of stearic acid sodium fumarate according to a prescription per unit. The invention further provides a preparation method of the compound omeprazole capsule. The compound omeprazole capsule which takes effect quickly and can inhibit omeprazole from being degraded by gastric acid is obtained through premixing, total mixing and filling. According to the technical scheme, the omeprazole sodium bicarbonate capsule which is high in initial dissolution rate (10-15 min) and faster in effect taking is obtained by screening the prescription composition and dosage of the compound omeprazole capsule and simplifying the preparation process, and due to the fact that the preparation process is convenient and fast, the production cost and the technical difficulty are reduced, and industrial large-scale production is better facilitated.

The present invention relates to the technical field of pharmaceutical preparations, and specifically discloses a sulanolone pharmaceutical composition, capsule and preparation method. The present invention uses silicified microcrystalline cellulose and mannitol as diluents, cross-linked sodium carboxymethyl cellulose as a disintegrant, and adds colloidal silicon dioxide as a glidant, and sodium stearyl fumarate as a lubricant, and prepares sulanolone capsules by dry granulation. The prepared sulanolone capsules have a faster dissolution rate, and compared with the reference preparation, the stability is significantly improved during storage, and the dissolution rate is also improved to a certain extent, which helps to increase the absorption and bioavailability of the product, and can achieve a good replacement for the original research product, and the preparation process is simple, the repeatability is good, and it is easy to realize industrial large-scale production, and it has a high value of promotion and application.

The invention discloses a Hu sheep rumen regulating agent and a preparation method thereof, belongs to feed additives, and particularly relates to a preparation method of the Hu sheep rumen regulating agent. The preparation method specifically comprises the following steps: mixing a plant extract and an alkaline compound, adding a functional additive, and uniformly stirring to obtain the Hu sheep rumen regulating agent, the plant extract comprises cinnamyl aldehyde, carvacrol and tea saponin; the alkaline compound comprises sodium bicarbonate and calcium hydrogen phosphate; the functional additive at least comprises sodium fumarate, sub-glycoside acid chalcone and salvia lactone. The prepared Hu sheep rumen regulating agent not only can effectively inhibit the generation amount of methane in the rumen fermentation process, but also is beneficial to improving the weight gain rate of Hu sheep.

The application discloses a geothrix and application, and relates to the technical field of microorganisms.The geothrix SGZ-164 is classified as Geothrix sp., has a preservation number of GDMCC No: 63128, a preservation date of January 2, 2023, and a preservation address of the 5th floor of No. 59 building in the courtyard, No. 100, Middle Martyrs Road, Guangzhou City, Guangdong Microbial Culture Collection Center.The geothrix Geothrix sp.SGZ-164 of the application can utilize sodium fumarate and trivalent iron as electron acceptors under anaerobic conditions, and can accelerate the degradation of organic matter.Using the new strain of the application, a high-efficiency soil in-situ remediation microbial preparation can be prepared.

The present invention provides a famotidine tablet and its preparation process. The famotidine tablet is composed of a core and a coating layer from the inside to the outside, and the core includes the following raw materials and auxiliary materials in parts by weight: 20 parts of famotidine, 80-120 parts of diluent, 5-8 parts of disintegrant, 0.4-0.7 parts of adhesive, 0.8-1.2 parts of lubricant; the coating layer material is made from the following auxiliary materials: alfalfa polysaccharide, L-fucitol, sodium stearate fumarate, and the mass ratio of alfalfa polysaccharide, L-fucitol, sodium stearate fumarate is 2-3:1-1.5:0.4-0.6. The famotidine tablets prepared by the prescription of the present invention and the process have good content and content uniformity, good dissolution curves in 0.1mol / L hydrochloric acid solution, pH4.5 phosphate buffer, pH6.8 phosphate buffer and purified water, and low total impurity content, which improves stability under accelerated conditions and long-term conditions.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to sitagliptin phosphate tablets as well as a preparation method and application thereof. According to the specific technical scheme, the sitagliptin phosphate tablet comprises sitagliptin phosphate, a filling agent, a disintegrating agent and a lubricating agent, the filling agent comprises microcrystalline cellulose, and the moisture content of the microcrystalline cellulose is smaller than 5%. When the lubricant is selected, the use of the lubricant sodium stearyl fumarate commonly used in the industry is avoided, so that the generation of impurities is effectively reduced. Meanwhile, the moisture content of microcrystalline cellulose in the filling agent is controlled, and the generation of impurities in the sitagliptin phosphate tablet is further reduced. Finally, the sitagliptin phosphate tablet which is high in purity, low in impurity content and stable in character is provided.

The invention provides a famotidine tablet and a preparation process thereof. The famotidine tablet is sequentially composed of a tablet core and a coating layer from inside to outside, wherein the tablet core is prepared from the following raw and auxiliary materials in parts by weight: 20 parts of famotidine, 80-120 parts of a diluent, 5-8 parts of a disintegrating agent, 0.4-0.7 part of an adhesive and 0.8-1.2 parts of a lubricant; the coating layer is prepared from the following auxiliary materials: alfalfa polysaccharide, L-fucose alcohol and sodium stearate fumarate, and the mass ratio of the alfalfa polysaccharide to the L-fucose alcohol to the sodium stearate fumarate is (2-3): (1-1.5): (0.4-0.6). The famotidine tablet prepared by adopting the prescription and the process is good in content and content uniformity, good in dissolution curve in a 0.1 mol / L hydrochloric acid solution, a phosphate buffer solution with the pH value of 4.5, a phosphate buffer solution with the pH value of 6.8 and purified water and low in total impurity content, and the stability under the acceleration condition and the long-term condition is improved.

The present invention provides a fluorouracil tablet and a preparation method. Fluorouracil tablets of the present invention include a core and a coating layer, wherein the core includes the following raw materials: fluorouracil, starch, starch slurry, magnesium stearate, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone; the coating layer is made of the following excipients: pullulan, hydroxypropyl methylcellulose acetate succinate, mannitol, sodium stearate fumarate; the coating layer is made of the following excipients in weight proportion: 25-35 parts of pullulan, 18-22 parts of hydroxypropyl methylcellulose acetate succinate, 8-12 parts of mannitol, and 4-6 parts of sodium stearate fumarate. The fluorouracil tablets prepared by the present invention can better stably enter the intestine, meet the requirements of enteric-coated tablets, and have low impurity content and good stability, which is conducive to reducing the occurrence of adverse reactions, better improving the drug safety of fluorouracil, and at the same time conducive to the performance of drug efficacy.

The invention relates to a lansoprazole and sodium bicarbonate combined medicine and a preparation method thereof. The combined medicine is prepared from lansoprazole, sodium bicarbonate, poloxamer 188, microcrystalline cellulose, croscarmellose sodium and sodium stearyl fumarate. The lansoprazole and sodium bicarbonate combined preparation prepared by the invention is stable and reliable, and is more remarkable in effect through scientific test verification; the lansoprazole and sodium bicarbonate combined preparation prepared by the invention can be rapidly absorbed in vivo, has higher Cmax, is suitable for the requirement of rapid effect taking, has higher AUC and high bioavailability, and is verified to have a very good effect through scientific experiments of pharmacokinetics in rabbits. In conclusion, the lansoprazole and sodium bicarbonate combined medicine prepared by the invention is obviously superior to related existing commercially available medicines.

The application provides a donepezil hydrochloride orally disintegrating tablet pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines.The technical scheme of the application is as follows: a donepezil hydrochloride composition, characterized in that the composition contains donepezil hydrochloride 6.25%, porous silicon carrier 2-6%, fumaric acid 1-3%, sodium carboxymethyl cellulose 0.7%, mannitol 53.05-79.05%, soluble starch 10-30%, and sodium stearyl fumarate 1%.The application provides a donepezil hydrochloride orally disintegrating tablet prescription process which is fast in disintegration, good in taste, high in safety, and feasible in large-scale production, is more suitable for the oral cavity characteristics of the elderly, and improves the compliance of patients in taking medicine.

The invention belongs to the technical field of drug production and preparation, and discloses a thioctic acid tablet and a preparation method thereof. The thioctic acid tablet of the invention contains thioctic acid and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier is a disintegrant, magnesium aluminum silicate, microcrystalline cellulose, a binder, a wetting agent and a lubricant, wherein the lubricant is a combination of silicon dioxide, sodium stearyl fumarate and polyethylene glycol, and the thioctic acid tablet solves the problem of easy sticking of thioctic acid tablets by adding magnesium aluminum silicate, microcrystalline cellulose and a specific disintegrant, lubricant and the like, and the obtained tablet has high stability.

The invention discloses a method for determining impurities in sodium stearyl fumarate. The method adopts high performance liquid chromatography for detection, the chromatographic column is a C1-C18 alkylsilane bonded silica gel, the mobile phase is a mixed solution consisting of C1-C5 primary alcohol, water, acetonitrile, trifluoroacetic acid or tetrahydrofuran, isocratic elution is adopted, and the detector is a mass detector. The method has good specificity, high sensitivity, high accuracy, simple operation and good repeatability.

The invention discloses an oral solid preparation of melogabalin benzene sulfonate, which comprises melogabalin benzene sulfonate, a sugar alcohol filler, a lubricant and a disintegrating agent, and the lubricant is a combination of glyceryl behenate and other lubricants. The other lubricant is selected from one or more of stearic acid, sodium lauryl sulfate, magnesium lauryl sulfate, magnesium aluminum metasilicate, magnesium stearate and sodium stearyl fumarate. According to the present invention, the growth change of the related substances in the melogabalin besylate preparation is researched, the prescription of the oral solid preparation is optimized, and the fact that the glyceryl behenate can significantly improve the stability of the melogabalin besylate preparation is accidentally found, and the preparation method is suitable for various preparation processes, and is more suitable for industrial production.

The invention provides high-transparency ultrathin flaky zinc stearate and a preparation method of the high-transparency ultrathin flaky zinc stearate. Comprising the following raw materials in parts by weight: 65-70 parts of double carbon chain stearic acid, 24-28 parts of nano zinc oxide, 150-180 parts of an ethanol-propylene glycol mixed solvent, 2.0-3.0 parts of a composite guiding agent, 1.0-1.5 parts of a transparent stabilizer, 0.2-0.4 part of a pH buffering agent and 0.8-1.0 part of colloidal silicon dioxide. The composite guiding agent is composed of oleamide and sodium stearyl fumarate according to the mass ratio of (1.8-2.2): 1.0, the double-carbon-chain stearic acid is composed of octadecane saturated fatty acid and hexadecane saturated fatty acid according to the mass ratio of (6.5-7.5): (2.8-3.2), and the transparent stabilizer is composed of triethyl citrate and polyvinylpyrrolidone K30 according to the mass volume ratio g / mL of (1.9-2.1): 1.0. Through the synergistic effect of the double-carbon-chain stearic acid, the composite guiding agent and the transparent stabilizer, the performance of zinc stearate is remarkably optimized, and finally an ultrathin flaky product with high transparency, low defect and thermal stability is obtained.

The invention relates to the technical field of secondary batteries, in particular to a sodium-rich hard carbon material, a preparation method thereof and a sodium ion battery. The preparation method of the sodium-rich hard carbon material comprises the steps that 1, organic sodium salt and rice hulls subjected to alkali washing treatment are subjected to first smashing according to the mass ratio of 1: (0.5-3), a mixture is obtained, the organic sodium salt is selected from one or more of trisodium isocitrate, sodium methyl acetoacetate, sodium linoleate, sodium fumarate, sodium benzene sulfate and sodium n-propoxide, and the organic sodium salt is selected from one or more of trisodium isocitrate, sodium methyl acetoacetate, sodium linoleate, sodium fumarate, sodium benzene sulfate and sodium n-propoxide; (2) carrying out carbonization reaction on the mixture to obtain a hard carbon precursor; and (3) carrying out sintering treatment, secondary crushing and sieving treatment on the hard carbon precursor to obtain the sodium-rich hard carbon material. The sodium-rich hard carbon material prepared by the method has the advantages of high initial coulombic efficiency, high gram volume and the like, and can greatly improve the electrochemical performance and cycle performance of the sodium ion battery when being used in the sodium ion battery.

The present invention provides an oral solid dosage form containing 5-fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azabicyclo[2.2.2]octane-3-carbonyl]-2,7-diazaspiro[3.5]nonan-2-yl}pyrimidine-5-yl)oxy]-N,N-di(propan-2-yl)benzamide as the active ingredient, which has good dissolution properties and storage stability. [Solution] An oral solid dosage form is provided, comprising hydroxypropyl cellulose as a binder at a concentration of 4.0 to 6.0% by weight per 100% by weight of the formulation, and stearyl sodium fumarate as a lubricant at a concentration of 2.0 to 10.0% by weight.

The invention discloses a health-care food suitable for maintaining ovary and delaying senescence of women and a preparation method of the health-care food. The health-care food is prepared from 5%-15% of pomegranate seed leavening, 4%-10% of maca enzymolysis peptide, 5%-10% of sea buckthorn seed supercritical extract, 4%-10% of lycium ruthenicum polysaccharide compound, 3%-7% of moutan bark nano dispersion, 2%-6% of motherwort ionic liquid extract, 4%-10% of phellinus igniarius mycelium leavening, 4%-12% of marine collagen oligopeptide, 14%-45% of microcrystalline cellulose, 8%-15% of pregelatinized starch, 3%-6% of hydroxy propyl cellulose, 0.5%-2% of sodium stearyl fumarate and 0.2%-1% of stevioside. Through scientific compatibility of various active components subjected to special treatment and combination of a modern biotechnology, ovarian function improvement and senescence delay are realized through multiple ways of endocrine regulation, oxidation resistance, microcirculation improvement, nutrition support and the like.

This application discloses a pharmaceutical excipient, sodium stearate fumarate impurity, and its preparation method, relating to the field of pharmaceutical excipient synthesis technology. A method for preparing a pharmaceutical excipient, sodium stearate fumarate impurity, includes the following steps: Step 1: Mixing octadecyl alcohol and fumarate chloride in a first solvent to carry out a condensation reaction; Step 2: Performing a first filtration, a first crystallization, and a second filtration on the condensation reaction product to obtain a crude product; Step 3: Dissolving the crude product obtained in Step 2 in a second solvent for purification, thereby obtaining the final product. The pharmaceutical excipient, sodium stearate fumarate impurity, is prepared according to the aforementioned method. Its structural formula is [not specified in the original text]. The method provided by this invention is simple, uses readily available raw materials, and yields a product with high purity and high yield. Its structure is confirmed by H-NMR and IR.

A coating composition comprises a) a polymeric film-former, and b) 20 wt.-% or more, relative to the solids content of the coating composition, of a gloss agent being sodium stearyl fumarate. The coating composition comprising sodium stearyl fumarate results in a coating with improved gloss.5