73results about How to "Guaranteed effective concentration" patented technology

The invention provides a method for preparing anti-infective agent long-acting injection, and relates to an anti-infective agent long-acting injection. Each 1,000 mL of injection comprises the following components: 10 to 500 g of anti-infective agent, 100 to 900 g of cosolvent, 0 to 100 g of blocker, local anesthetic or stabilizer, and the balance of oil solvent. The method method for preparing the injection comprises: 1, dissolving 10 to 500 g of anti-infective agent in 100 to 900 g of cosolvent and mixing the two well; 2, adding 0 to 100 g of blocker and/or local anesthetic or stabilizer; and 3, adding the oil solvent till full volume and mixing thoroughly to form a uniform system. The method has antibacterial medicaments dissolved in the cosolvent first and then uniformly dispersed in the oil solvent capable of dissolving the antibacterial medicaments mutually so as to prolong the absorption rate of organisms to the medicaments, thereby maintaining the effective concentration of the medicaments in the organisms for a long time, achieving the long-acting effects and reducing the toxic effects of the medicaments.

The invention discloses an organic composite reinforced concrete rust inhibitor and a preparation method thereof. According to the invention, the rust inhibitor is prepared from well-mixed materials of, by weight: 30-40% of alcohol amine carboxylate, 5-10% of sodium monofluorophosphate, 0.1-0.5% of an anionic surfactant, and balance of water. The rust inhibitor has a good diffusion performance inconcrete, and can simultaneously acts upon the cathodes and the anodes of steel bars. The trust inhibitor forms stable chelate rings with the steel bars, and has an excellent rust inhibiting performance. Also, the anions in the rust inhibitor can be combined with calcium ions in the concrete, such that precipitates are formed. With the precipitates, capillary pores in the concrete can be obstructed, and the chloride ion penetration resistance of the concrete can be improved.

The present invention relates to a Xiaomi vagina expansion suppository, which comprises an active component, a matrix and an expansible expansion carrier. The present invention further relates to a preparation method and a detection method of the expansion suppository. According to the expansion suppository, seven original leading technologies are adopted; the expansion suppository is made into a hollow expansion suppository, and the matrix and the active component are completely separated, such that stability of the expansion suppository is increased compared with stability of the ordinary suppository; the active component, the dispersion carrier and the absorption blocking agent are combined so as to increase an active component dissolution rate, well release the active component, and prolong a drug action time; and the Xiaomi vagina expansion suppository has effects of rapid effect, prolonged action time, drug liquid outflow prevention, vagina cleaning, secondary infection prevention, and the like.

The invention discloses a solid corrosion and scale inhibitor for an oil field, which relates to the technical field of chemical medicine reagents used for the oil field. The solid corrosion and scale inhibitor comprises the following ingredients: 2-phosphonic acid butane 1, 2, 4-tricarboxylic acid PBTCA, polyethyleneglycol, sodium hexametahposphate, span-60 and stearic acid, wherein each ingredient accounts for the mass percent of the sum of all the ingredients as follow: 30 percent to 40 percent of 2-phosphonic acid butane 1, 2, 4-tricarboxylic acid PBTCA, 10 percent to 15 percent of polyethyleneglycol, 10 percent to 15 percent of sodium hexametahposphate, 15 to 25 percent of span-60 and 20 percent to 30 percent of stearic acid. The invention is particularly suitable for well tubes of oil-gas wells with server corrosion and scale conditions, and has good corrosion and scale inhibition effects on underground pipe posts and equipment.

The invention relates to a nifuratel-nysfungin vaginal expandable suppository and its preparation method and detection method. The nifuratel-nysfungin vaginal expandable suppository comprises a drug-containing matrix comprising nifuratel, nysfungin and a matrix, and also comprises an expandable carrier. Through use of colloidal silicon dioxide in the drug-containing matrix, nysfungin hygroscopicity is reduced and suppository stability is improved. Nifuratel, nysfungin, povidone and hydroxypropyl methylcellulose form a skeleton clathrate so that nysfungin and nifuratel stability are further improved and the time of action produced by the active components on the vagina is further prolonged. Propylene glycol monostearate and Tween 80 can promote absorption of the active components by the vagina and suppository bioavailability is improved. The nifuratel-nysfungin vaginal expandable suppository utilizes seven novel lead-edge technologies and has the advantages of drug liquid leakage prevention, high stability, lasting curative effects and secondary infection prevention.

The invention relates to a recombinant human interferon alpha 2a vaginal expansion suppository and preparation and detection methods thereof. The expansion suppository comprises a medicated mucous layer, a substrate layer and an expansion carrier; the medicated mucous layer consists of recombinant human interferon alpha 2a and a protective agent, wherein the protective agent improves the stability of recombinant human interferon alpha 2a; when in local application, the medicated mucous layer can form mucosa by which the medicated mucous layer can be attached on vaginal skin to promote skin absorption so as to further improve the bioavailability of the suppository. The expansion suppository is characterized in that a substrate further comprises a specific hardening agent. Due to the adoption of six unique leading technologies, the recombinant human interferon alpha 2a vaginal expansion suppository has the beneficial effects of preventing outflow of liquid medicine, being high in stability and lasting in curative effect, and preventing superinfection, etc.

The invention discloses a preparation method of a solid corrosion-inhibition scale-inhibition bar used for an oil field, which relates to a production method of a chemical medicament used for the oil field. The preparation method comprises the following steps of: (1) mixing 30 to 40 percent of 2-phosphonobutane-1,2,4-tricarboxylic acid, 10 to 15 percent of polyethylene glycol, 10 to 15 percent of sodium hexametaphosphate, 15 to 25 percent of Span-60 and 20 to 30 percent of stearic acid evenly, wherein the percent is the mass percent of the sum of each component occupying all the components; and (2) putting all the evenly mixed components into a bar type mold, pressing into a bar type by using a press machine and forming a finished product, wherein the pressure applied by the press machine is 15 to 20 tons. The method has the advantages of simple preparation process, even mixing of the components, trouble saving and labor saving, so that the method is suitable for mass and industrialized production and large-scale popularization and application.

The present invention discloses a glycyrrhizia polysaccharide liposome preparation method, reverse-phase evaporation method is used, the established technological conditions are as follows: the mass ratio of soybean lecithin to cholesterol is 2: 1-10: 1, the mass ratio of soybean lecithin to glycyrrhizia polysaccharide is 5: 1-25: 1, the mass ratio of Tween 80 to soybean lecithin is 1: 1-1: 20, the water bath temperature is 25-65DEG C, and ultrasonic time is 5min-25min. According to the method, for the first time, the glycyrrhizia polysaccharide is prepared as liposome, by response surface ptimization, raw materials can be saved to the greatest degree, meanwhile higher drug encapsulation efficiency (up to 79.12%) can be obtained, and combination with ultrasound effect, the prepared liposome is more stable and more uniform, and the average particle diameter is 136.4 +/-0.151nm.

The invention relates to a Fukang expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable suppository comprises active ingredients, a matrix and an expansion carrier. The active ingredients and the matrix form a drug-containing matrix, which is coated on the surface of the carrier. The active ingredients include walnut oil and further include motherwort and radix polygonati officinalis. The additional motherwort and radix polygonati officinalis can improve the curative effect of the Fukang expandable vaginal suppository on symptoms of leukorrhea with reddish discharge and bearing-down pain in lower abdomen; the starch sodium glycolate and walnut oil are prepared into a solid dispersion to improve the solubility of walnut oil and reduce volatilization of walnut oil; the stearic acid palmitic acid glycol ester improve the stability of the suppository; and the dextrin increases cohesiveness of the expandable suppository and is beneficial to forming the expandable suppository. The Fukang expandable vaginal suppository employs six unique technologies, and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

The invention relates to a compound metronidazole expansion suppository. The compound metronidazole expansion suppository is vaginal suppository prepared by metronidazole, total saponins of ginseng stems and leaves, and vitamin E which are taken as active ingredients, and proper matrix; an expandable expansion carrier is arranged in the suppository; a medicated layer formed by the active ingredients and the matrix is coated on the surface of the expansion carrier; after saturated water absorption, the expansion carrier has the radial expansion value more than 1.1. The invention also provides a detection method of the compound metronidazole expansion suppository. The method comprises the contents such as expansion value measurement, weight difference measurement, etc. The expansion suppository applies six original technologies including 'one-time suppository filling integrated forming' technology, 'inner core expansion factor control' technology, 'human engineering suppository type' technology, 'treatment-cleaning integration' dosage form, 'vaginal inner-attached administration' technology and 'side leakage prevention suppository body design'; the medicated layer of the compound metronidazole expansion suppository is fully contacted with the inner wall of the vagina, so that liquid medicine is prevented from flowing outside; the compound metronidazole expansion suppository also has the effect of cleaning the vagina so as to prevent superinfection.

The invention relates to a traditional Chinese medicine externally-applied preparation for treating oral leukoplakia and preventing diseases caused by oral leukoplakia canceration, specifically, a Chinese patent drug prepared from traditional Chinese medicinal herbs. The traditional Chinese medicine externally-applied preparation is prepared from the following traditional Chinese medicine raw materials according to the parts by weight: 18-24 parts of subprostrate soplhor root, 17-21 parts of bistort rhizome, 17-23 parts of dahurian patrinia herb, 8-12 parts of Cortex Dictamni, 18-25 parts of common selfheal spike, and 3-6 parts of airpotato yam.

The invention discloses doxycycline hydrochloride long-acting injection and a preparation method thereof. The injection comprises the following components: 5-30% (W/V) of doxycycline hydrochloride, 25-70% (V/V) of compound organic solvent, 0.01-0.1% (W/V) of oxidation inhibitor, 0.5-10% (W/V) of magnesium compound complexing agent and 0.1-1% (W/V) of calcium compound complexing agent. The preparation method comprises the following steps of: mixing the components, adopting alkali to adjust the pH value to 8.0-9.0, and adding water for injection to 100% (V/V). According to the invention, the problem that doxycycline injection is easy to oxidize and decompose can be effectively solved.

The invention discloses pachymaran polylactic acid nanoemulsion. The nanoemulsion is prepared from raw materials including acetone, polylactic acid, pachymaran and propylene glycol block polyether F68 through a multiple emulsion method. The invention further discloses a preparing method of the pachymaran polylactic acid nanoemulsion and application to preparation of an immunological enhancement drug. Compared with the prior art, pachymaran is prepared into the pachymaran polylactic acid nanoemulsion through the multiple emulsion method, obtained nanoemulsion suspension is high in encapsulation efficiency, the drug is convenient to absorb and is slowly released, the pharmacological effect is effectively prolonged, and the pachymaran polylactic acid nanoemulsion has the immunological enhancement function and is of great significance in resisting pestilence. The pachymaran polylactic acid nanoemulsion has no side effects serving as novel traditional Chinese veterinary medicine.

The invention relates to a metronidazole expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises metronidazole, a matrix and an expansion carrier. The drug-containing matrix also includes a resin; a resin compound formed by the resin with metronidazole can improve stability of the suppository and cooperate with an acidifier to prolong effect time of metronidazole on the vagina, extend therapeutic effect and maintain the specific acid environment and self-cleaning function of the vagina; and the chitosan can promote the absorption of metronidazole by the vagina and improve the bioavailability of the suppository. The metronidazole expandable vaginal suppository employs seven unique technologies and has beneficial effects of prevention of outflow liquid and secondary infection.

The invention discloses a lentinan-modified carbon nano-tube. The lentinan-modified carbon nano-tube is prepared by grafting a carbon nano-tube with lentinan by virtue of a covalent bond modification method. The invention further discloses a preparation method of the lentinan-modified carbon nano-tube and application of the lentinan-modified carbon nano-tube in preparation of immunological enhancement drugs. Compared with the prior art, the lentinan-modified carbon nano-tube has the advantages that the problems that components of lentinan are easily oxidized and are difficulty prepared into a preparation method are solved, the absorption of drugs is facilitated, and the drugs can be slowly released, so that the drug effect is effectively prolonged, the immunologic functions of animals can be remarkably improved, and the lentinan-modified carbon nano-tube is of an important significance in resisting of diseases. Meanwhile, the lentinan-modified carbon nano-tube is a novel Chinese veterinary drug and has no side effect.

The invention discloses Chinese yam polysaccharide polylactic acid glycolic acid nanoparticles which are prepared from acetone, polylactic acid glycolic acid, Chinese yam polysaccharide and poloxamer 188 through a compound emulsion method. The invention further discloses a preparation method of the Chinese yam polysaccharide polylactic acid glycolic acid nanoparticles and application thereof in preparing immunity enhancement drugs. Compared with the prior art, the nanoparticles have the advantages that the nanoparticles are high in suspension encapsulation rate, stable in drug property and capable of making drug to be slowly released in animal bodies and effectively prolonging efficacy, have immunity enhancement effect and are of important significance in preventing and treating animal epidemic diseases. In addition, the nanoparticles serve as a novel Chinese veterinary drug and are free of side effect.

The invention relates to a palmatine vaginal swelling bolt as well as a preparation method and a detection method thereof. The swelling bolt comprises a medicated substrate formed by micronized palmatine and a substrate, and an expansion carrier, wherein the medicated substrate also comprises xylitol anhydride glycerol monostearate, karaya gum, sorbitol lauric acid ester, myristyl alcohol and spherical saccharose. The palmatine vaginal swelling bolt disclosed by the invention is high in stability, significant in curative effect, not easy to deform, and free of rancidity, and the provided palmatine vaginal swelling bolt adopts six original leading technologies, and has the beneficial effects that the soup is prevented from flowing out, the palmatine vaginal swelling bolt is quick to take effect, secondary infection is prevented and the like.

The invention belongs to the technical field of daily chemical industry, and particularly relates to toothpaste containing bear gall microcapsules. The bear gall microcapsule is mainly prepared from abear gall extract, corn starch, microcrystalline cellulose, a polymeric polymer material, tocopheryl acetate and the like. The composition is combined with the bear gall extract to prepare the toothpaste, so that on one hand, the stability of the bear gall extract and the toothpaste can be remarkably improved, and the appearance, the pH value, the consistency and the like can be kept in a normalstate under low-temperature or high-temperature conditions; on the other hand, the bear gall extract can be kept at a certain effective concentration during tooth brushing and within a certain periodof time after tooth brushing, and the effects of remarkably improving symptoms such as dental ulcer, swelling and aching of gum, gingival bleeding and gingival inflammation are achieved; and moreover,the attractiveness of the toothpaste can be improved, the quality of smell, taste and the like is better, and the toothpaste has good market acceptability.

The invention discloses compound feed for improving the estrus rate of s Sanyuan replacement gilt. The compound feed comprises the following ingredients in parts by weight: 55-65 parts of corns, 7-10parts of soybean meal, 10-15 parts of fiber compounds, 1-2 parts of soybean oils, 1-2 parts of corn starches, 0.5-1 part of table salt, 1-2 parts of mountain flour, 1-2 parts of c calcium hydrogen phosphate, 0.3-0.5 part of lysine, 0.4-0.8 part of threonine, 1-2 parts of Chinese herbal medicine fermentation products, 0.1 part of choline chloride, 0.02 part of antioxidant, 0.05 part of mildew-proofagent and 3-4 parts of gilt compound premix materials. In the compound feed disclosed by the invention, key raw materials are subjected to fermentation and enzymolysis, nutrition is comprehensive, and the normal growth of the reproductive system of the Sanyuan replacement gilt can be guaranteed. Since the corn flour and the soybean oils are added, a ratio of energy from the starch and fat in feedenergy can be guaranteed, and triglyceride and total cholesterol concentrations in gilt blood can be improved so as to be favorable for puberty startup. Since a fiber compound is used for replacing bran, the secretion of insulin is accelerated so as to be favorable for the sex hormone secretion of the replacement gilt, the replacement gilt is accelerated to enter the estrus, the intestinal floraof the replacement gilt can be regulated, and the intestinal health of the replacement gilt can be maintained.

The invention discloses a rotary motion type automatic electrolytic polishing method and device for an EBSD test sample. The device comprises a liftable cantilever support (2) with a positioning cone,an electrolytic polishing tank (6) with a hemisphere inner bottom surface , a herringbone clamp (7), a position adjusting chuck (5) and a motor (1). The method comprises the steps of sample grinding,sample (10) installation, sample and anode connection, electrolytic polishing tank and cathode connection, electrolytic polishing solution (9) preparation, electrolytic polishing and sample post-treatment. The electrolytic polishing tank on the inner bottom surface of the hemisphere is used as a cathode for electrolytic polishing, so that voltage and current density contour lines are concentrically and circularly uniformly distributed in the electrolytic polishing solution, the stability of voltage and current of a to-be-polished surface is greatly improved, and the quality of the electrolytic polishing surface is greatly improved.

The invention relates to a kunjing expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises a traditional Chinese medicine extract, furazolidone, a matrix and an expansion carrier. The traditional Chinese medicine composition, furazolidone and the matrix form a drug-containing matrix, which is coated on the surface of the expansion carrier. The traditional Chinese medicine extract is mainly prepared from Radix Bupleuri and Edelweiss through extraction; and the traditional Chinese medicine extract also includes fructus kochiae and Pulsatilla. The stearic acid and sodium dextran in the drug-containing matrix can cooperate to promote absorption of the traditional Chinese medicine extract and furazolidone and improve the bioavailability of the expandable vaginal suppository; glucan can also promote the formation of the expandable vaginal suppository; and cellulose acetate prolong curative effect of the expandable vaginal suppository. The kunjing expandable vaginal suppository is an up and down double-layer expandable suppository, employs seven unique technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.

The invention relates to a sodium houttuyfonate vaginal expansive suppository and a preparation method and a test method thereof. The expansive suppository comprises sodium houttuyfonate-containing matrix and an expansive carrier; in the sodium houttuyfonate-containing matrix, acid particles and alkaline particles generate carbon dioxide when meeting water, so as to foam, and in combination with the expansive action of the expansive carrier, sodium houttuyfonate can reach vaginal deep site and fold site to improve the drug action range; ascorbic acid in acid particles has an antioxidant effect to improve the stability of the suppository; buffer salt particles in the sodium houttuyfonate-containing matrix provide an appropriate pH environment which is in favor of the complete effervescence of the suppository and improves the bioavailability of sodium houttuyfonate in the suppository; the hollow effervescent vaginal suppository seals the drug-containing layer in the matrix hollow cavity, so as to improve the stability of the expansive suppository; the sodium houttuyfonate vaginal expansive suppository adopts six original advanced techniques, and has the beneficial effects of prevention of medicinal liquid from flowing out, high stability, lasting therapeutic effect, prevention of secondary infection, and so on.

The invention provides a compound chloramphenicol vaginal swelling suppository, as well as a preparation method and a detection method thereof. The swelling suppository comprises a drug-containing matrix formed by an active component and a matrix, and a swelling vector, wherein the active component comprises chloramphenicol, boric acid, vitamin A and vitamin D2; the drug-containing matrix also comprises octadecyl sodium fumarate, sucrose monopalmitate and polyoxyethylenealiphatic alcohol ether; the layer out of the core of the swelling suppository is coated with an ointment layer. The compound chloramphenicol vaginal swelling suppository has the beneficial effects of high stability and small vaginal irritation, adopts seven original advanced technologies, has the beneficial effects of preventing a liquid medicine from overflowing, preventing secondary infection and the like, and is quick in response and long in curative effect.

The invention relates to a detection method for a vaginal expansion plug. The detection method comprises an expansion value determination method and a weight difference determination method. The detection method is more scientific and has high reproducibility. On the other hand, the invention also provides the vaginal expansion plug which is suitable for detection of the detection method. The expansion plug comprises an expandable expansion carrier containing a medicinal substrate; the expansion carrier is divided into a front end and a tail end; the front end and the tail end have different expansion values and expansion speeds, so that liquid medicine can be prevented from flowing out, and the concentration of the medicine in the vagina is kept.