Compound polysaccharide anti-hemorrhagic thin film and preparation method thereof

Abstract

The invention discloses a compound polysaccharide anti-hemorrhagic thin film and a preparation method thereof.The thin film is prepared from, by mass, 10-20 parts of chitosan, 2-8 parts of glucose, 3-6 parts of methylcellulose, 1-5 parts of gelatin, 4-7 parts of pectin, 4-7 parts of sodium trimetaphosphate, 8-20 parts of polyhydric alcohols, 5-8 parts of agar, 2-8 parts of sorbic acid, 5-10 parts of sodium alginate, 3-6 parts of panax notoginseng, 1-3 parts of sodium fumarate and 2-5 parts of sanguisorba officinalis.A polysaccharide serves as a matrix, proper anti-hemorrhagic components and auxiliaries are added, and the film-shaped anti-hemorrhagic material is prepared.Compared with conventional powder or spray, the film-shaped anti-hemorrhagic material can stop bleeding in two aspects synchronously.In the early time of bleeding, the film body is similar to tourniquet and can quickly stop bleeding, the anti-hemorrhagic components in the film synchronously stop bleeding at the same time, and the thin film has dual anti-hemorrhagic functions, greatly shortens bleeding time and is obvious in anti-hemorrhagic effect and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of medical hemostatic materials, in particular to a composite polysaccharide hemostatic film and a preparation method thereof. Background technique [0002] Bleeding remains the leading cause of death in trauma patients. At present, the effective control method for aortic bleeding only stays on the operating table, but for field or acute trauma bleeding patients, the best treatment time is often missed due to excessive blood loss on the way to the emergency room after bleeding, so , How to effectively control bleeding in the first time has become the most challenging and important task at present. Compared with some traditional methods of surgical control of hemostasis, some advanced hemostatic materials and test punctures have recently appeared, which can be used for field hemostasis or emergency life-saving hemostasis. Oxidized cellulose, fibrin glue and synthetic glue point pricking have been used for l...

AI Technical Summary

Problems solved by technology

Oxidized cellulose, fibrin glue and synthetic glue point pricking have been used for local hemostasis trials; molecular sieves and chitosan are the latest generation of local hemostasis trials, and their effects and safety are currently being studied; recombinant Activated coagulation factor VII (FVIIa) is the most ideal hemostatic agent for trauma hemostasis, but its safety for trauma patients has yet to be investigated through multiple randomized controlled experiments.

[0003] The traditional methods of hemostasis mainly include suturing, pressing and dressing. The main hemostatic products include first aid kits, four-head bands, hemostatic gauze, tourniquets and bandages. The main method, but there will be great defects during or after use, so it is greatly limited in clinical application

For example, suture hemostasis is very effective for traumatic bleeding of soft tissues and large blood vessels, but the effect of hemostasis on solid organs with high fragility and rich blood flow is not ideal, and it is very easy to cause needle holes or hemorrhagic tissue damage. This affects the normal functions of the kidneys, brain and other substantial organs; pressing to stop bleeding requires pressing the capillaries for tens of minutes to promote the aggregation of platelets, which is the most direct way to stop bleeding on the body surface. A lot of bleeding but the hemostatic effect is not ideal

There are also many defects in the process of using the tourniquet: if the tourniquet is not properly treated for the wound or the time and pressure are not correctly grasped, it may cause pain near the wound, nerve damage, and even tissue necrosis in severe cases; For special and relatively common trauma, such as irregular shape, deep, narrow, arterial rupture and other wounds, the hemostatic effect is not good; the tourniquet is easy to fall off, causing secondary bleeding; the use of the tourniquet will induce soft tissue around the surgical wound. Reactive hyperemia, significant drop in oxygen content, etc.

It can be seen that traditional hemostatic materials can no longer meet the clinical needs of safe hemostasis in modern surgery and emergency trauma hemostasis. The shortcomings of these hemostasis methods need other new hemostatic materials to make up for

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