The invention relates to an erlotinib (Erlotinib Hydrochloride) sustained-release preparation for treating the non-small cell lung cancer. The erlotinib sustained-release preparation is prepared fromthe following raw and auxiliary materials in percentage: 30% to 50% of erlotinib, 10% to 40% of sustained-release material, 30% to 50% of filler, 1% to 10% of solubilizer and 1% to 4% of lubricant. The invention further provides a preparation method of the sustained-release tablets. The preparation method comprises the steps of: firstly, placing the erlotinib, the sustained-release material and the filler into a high-efficiency wet granulator to uniformly mix; then adding the solubilizer into purified water to prepare solution; adding a proper volume of solution into a pot to carry out wet granulation; after particles are dried, adding a proper volume of lubricant; and after uniformly mixing, carrying out tabletting to form the tablets. Compared to a common drug, the erlotinib sustained-release preparation has the advantages of reducing the "peak valley" effect of in-vivo release of the drug, reducing a probability that cancer cells generate drug resistance, reducing adverse reactionson a patient, which are generated due to excessively high blood concentration of the drug, enabling the blood concentration to be continuously and stably kept to optimal treatment concentration, improving bioavailability of the drug, reinforcing the curative effect and improving administration safety.