41results about How to "Avoid the extraction process" patented technology

The invention relates to a method for preparing 6- gingerol and 8- gingerol with fresh ginger. It is characterized in that it compries following steps: cutting fresh ginger into sheets, drying at lowtemperature, disintegrating, sifting with screen of 100 order, heating and refluxing and extracting with acetic ester or acetone, or extracting through immersion, extracting for three times, combiningextract liquid, decompressing and recovering solvent, getting extract concretem dissloving it with acetic ester, treating it with chromatographic silica gel and washing it with benzinum purificatum acetic ester with gradient solvent, checking washing process by using TLC, decompressing to recover solvent and getting coarse 6- gingerol and 8- gingerol; washing coarse product with chloroform- carbinol solvent in Sephadex LH20 gel column, checking washing process with TLC, and getting washung liquid containing 6- gingerol and 8- gingerol with higher purity, decompressing to recover solvent and getting pure 6- gingerol and 8- gingerol, checking content with HPLC. The invention is characterized by simple operation, high productivity and production of two kinds of product at the same time.

The invention discloses a method for extracting ginkgo leaf extract from ginkgo leaves, which includes steps of: mixing ginkgo leaves and solid-phase reagent according to quality ratio of 1 to 0.1-2, fully grinding the mixture in a ball mill, fetching out the grinded powder, adding water to dissolve, filtering, adjusting pH value of supernatant to 2.0-6.0, separating and purifying. The invention has advantages of no pollution, high product purity, less solvent residue, convenient operation, short production period, low production cost, and better popularization and application prospect.

The invention discloses a preparation method of erlotinib hydrochloride. The method is characterized by taking 3,4-dihydroxybenzaldehyde as a raw material, synthesizing to obtain 6,7-dimethoxyquinazoline-4-one, directly chloridizing to obtain a product, allowing the product to react with meta-ethynylaniline to obtain the erlotinib hydrochloride. The method has mild reaction condition and is applicable to industrialized production.

The invention discloses a method of extracting tea polyphenol and separating monomer EGCG from tea, which is characterized in that: tea and solid phase alkali are mixed according to mass ratio of 1:0.1 to 2 and grinded jointly and mixed evenly before solved using water, stirred and centrifuged; inorganic acid is added into the supernatant to regulate pH value into 1.0 to 8.0, thereby getting sedimentation and filtering; filter residue is monomer EGCG; the filtrate is tea polyphenol solution which is then dried to get crude product of tea polyphenol. The extraction and separation method adoptsthe mechanical and chemical technique to extract tea polyphenol and separate monomer EGCG. The method of extracting tea polyphenol and separating monomer EGCG from tea has the advantages of new extraction and separation technique without solvent, simple technique, low cost, high yield, high product purity, short production period, no pollution basically and wide industrial prospect for extractingand separating.

The invention discloses a method for separating and extracting 1,3-propylene glycol from fermentation broth. The method comprises the following steps: (1) separating 1,3-propylene glycol fermentation broth to remove insoluble solids; (2) adding an aromatic aldehyde solvent, an acetalation catalyst, and a phase transfer catalyst into the fermentation broth, and carrying out acetalation reactions of 1,3-propylene glycol under stirring; (3) allowing the reaction liquid to stand still for a while to carry out layering, wherein the aromatic aldehyde solvent and acetalation products are in the upper layer (organic phase layer), and the lower layer (water phase layer) is removed through phase separation; (4) subjecting the obtained organic phase layer to distillation to obtain acetalation products; (5) adding pure water and a hydrolysis catalyst to carry out hydrolysis of the acetalation products, allowing the system to stand still for a while to carry out layering, wherein the aromatic aldehyde solvent is the organic phase layer, and 1,3-propylene glycol enters the water phase layer, and filtering the water phase layer or subjecting the water phase layer to centrifugation to remove the catalyst; (6) subjecting the obtained water phase layer to rectification and dehydration, and carrying out rectification to collect the 1,3-propylene glycol fraction. The extraction method has the advantages that the technology is simple, no toxic extracting agent is used, and the purity and yield of product are high.

The invention discloses a method for separating and extracting 1,3-propanediol from a fermentation broth, comprising: (1) separating and removing solids in the fermentation broth; (2) heating, concentrating and evaporating the fermentation broth, removing the precipitated solids, and obtaining 1,3-propylene glycol concentrated solution; (3) add aromatic aldehyde solvents to the concentrated solution, continue heating and concentrating until all water is removed, and obtain an organic solution containing 1,3-propylene glycol; (4) add a catalyst to the organic solution for condensation Hydroformylation reaction; (5) Distill the reaction liquid in step (4) to distill out the unreacted aromatic aldehyde solvent; (6) Add pure water and catalyst to the product of step (5) for hydrolysis, and the aromatic aldehyde solvent is the organic phase layer, 1,3-propanediol enters the lower water phase layer, and the water phase layer is filtered to remove the catalyst; (7) the step (6) water phase layer is rectified and dehydrated, and the 1,3-propanediol fraction is collected as the product. The method of the invention has simple process, avoids the use of toxic extractant, and the separated product has high purity and high yield.