A method for directly preparing 6-aminopenicillanic acid from penicillin fermentation broth

Abstract

The invention belongs to the biological medicine field, and relates to a method using penicillin fermentation liquor for direct preparation of 6-aminopenicillanicacid. Preparation methods of the 6-aminopenicillanicacid in the prior art have the technical problems of large environmental pollution, high energy consumption, low product yield and the like; in order to overcome the technical problems, the invention provides the method using the penicillin fermentation liquor for direct preparation of the 6-aminopenicillanicacid, the method avoids use of butyl acetate, n-butyl alcohol and other organic solvents, improves the product yield, reduces the energy consumption in the process of preparation, is a green energy-saving 6-aminopenicillanicacid production method, and is very suitable for popularization and application in industry.

Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a method for directly preparing 6-aminopenicillanic acid from a penicillin fermentation liquid. Background technique

[0002] 6-aminopenicillanic acid (6-APA) is a white flaky crystal, which is an important intermediate for the synthesis of various semi-synthetic penicillins and has a wide range of uses. Using this as a raw material for chemical structure modification and connecting side chains of different structures can produce new semi-synthetic penicillins that are sensitive to penicillin-resistant bacteria and have a wider antibacterial spectrum, such as ampicillin, amoxicillin, and phenoxymethyl penicillin. Penicillin, and other semi-synthetic penicillins with broader antibacterial spectrum. At present, the annual output of 6-APA in China exceeds 30,000 tons.

[0003] At present, there are mainly microbial enzyme-catalyzed cleavage methods and chemical cleavage meth...

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