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Method for extracting Gingko extract from ginkgo leaves

A technology for Ginkgo biloba leaves and extract, applied in the field of extracting Ginkgo biloba extract, can solve the problems of easy change of active ingredients, residual organic solvent, low product purity, etc., and achieve the effects of shortening production cycle, low production cost and high product purity

Active Publication Date: 2012-08-08
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, these methods need to consume a large amount of organic solvents, which are easy to pollute the environment and easily cause the residue of organic solvents in the product
At the same time, since solvent extraction requires high temperature and long-term reflux, many active ingredients are prone to change, and impurities with similar polarities are also extracted together, resulting in low product purity
In addition, most of these methods have cumbersome steps and a long cycle
At present, there is no report on the extraction of GBE by mechanochemical extraction technology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] At room temperature, mix 20 g of ginkgo biloba raw materials with 2 g of sodium bicarbonate; grind the mixture in a ball mill for 2 min; take out the ground powder, add 400 g of water to it, and stir for 30 min; filter, take the supernatant, and add acetic acid to adjust the pH value to 5.0 ; Then pass through a macroporous resin chromatography column, concentrate and dry to obtain the product GBE. The yield of the product is 1.54%. Through HPLC detection, the HPLC content of ginkgo flavonoids is 23.46%, and the content of ginkgolides is 5.67%.

Embodiment 2

[0037] At room temperature, mix 20 g of ginkgo biloba raw materials with 2 g of sodium bicarbonate; grind the mixture in a ball mill for 2 min; take out the ground powder, add 100 g of water to it, and stir for 5 min; filter, take the supernatant, and add hydrochloric acid to adjust the pH value to 2.0 ; Then pass through a macroporous resin chromatography column, concentrate and dry to obtain the product GBE. The yield of the product is 1.65%, and the content of ginkgo flavonoids is 23.65%, and the content of ginkgolides is 5.38% through HPLC detection.

Embodiment 3

[0039] At room temperature, mix 20 g of ginkgo biloba raw material with 2 g of sodium bicarbonate; grind the mixture in a ball mill for 15 min; take out the ground powder, add 100 g of water to it, and stir for 30 min; filter, take the supernatant, and add hydrochloric acid to adjust the pH value to 3.0 ; Then pass through a macroporous resin chromatography column, concentrate and dry to obtain the product GBE. The yield of the product is 1.75%, and the content of ginkgo flavonoids is 22.76%, and the content of ginkgolides is 5.34% through HPLC detection.

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PUM

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Abstract

The invention discloses a method for extracting ginkgo leaf extract from ginkgo leaves, which includes steps of: mixing ginkgo leaves and solid-phase reagent according to quality ratio of 1 to 0.1-2, fully grinding the mixture in a ball mill, fetching out the grinded powder, adding water to dissolve, filtering, adjusting pH value of supernatant to 2.0-6.0, separating and purifying. The invention has advantages of no pollution, high product purity, less solvent residue, convenient operation, short production period, low production cost, and better popularization and application prospect.

Description

(1) Technical field [0001] The invention relates to a method for extracting ginkgo extract from ginkgo leaves. (2) Background technology [0002] The active ingredients in Ginkgo biloba extracts (GBE) are mainly flavonoids and lactones. Ginkgo biloba extract has a variety of physiological activities, among which the flavonoids are mainly quercetin, kaempferol, and isorhamnetin glycosides, which have vitamin P-like effects, not only reducing capillary permeability, but also dilating the crown. Blood vessels can significantly increase coronary flow and cerebrovascular flow, and can improve microcirculation, reduce myocardial oxygen consumption, and scavenge free radicals. It is widely used in the treatment and symptom improvement of cardiovascular and cerebrovascular diseases and senile dementia. Ginkgolide compounds are specific antagonists of platelet activating factor (PAF), and bilobalide has a good therapeutic effect on nervous system diseases. [0003] There are many t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/28A23L1/29A23L1/30A23L33/105
Inventor 王平朱兴一谢捷苏为科陈丹龙周陈锋
Owner ZHEJIANG UNIV OF TECH
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