178results about How to "Process safety and environmental protection" patented technology

The invention discloses a method for producing thiuram disulfide as thiofide by a continuous micro-reaction system. According to the method, three processes including secondary amine-NaOH solution mixing, CS2-secondary amine condensation reaction and sodium dithiocarbamate oxidation reaction are sequentially completed by a micro-mixer and a micro-reactor which are connected in series; reaction materials are efficiently mixed by the micro-reaction device, and side reactions such as overoxidation and the like are avoided; by means of a series-integrated operation mode, production efficiency is improved, and product stability is improved. The method can be applied to production of multiple thiuram vulcanizing agents such as tetramethyl thiuram disulfide, tetraethylthiuram disulfide, tetrabutylthiuram disulfide and the like, the yield can reach 98% or higher, and product purity is high.

The invention relates to a low-cost preparation method for palbociclib. The low-cost preparation method comprises the following steps: by taking 2,4-dichloro-5-cyanopyrimidine as an initial raw material, performing cyano Grignard and hydrolysis so as to obtain 5-acetyl-2,4-dichloropyrimidine, protecting carbonyl, performing amination, removing carbonyl, performing acylation reaction by using diketene and amino so as to obtain 5-acetyl-4-acetoacetamide-2-chloropyrimidine, performing intramolecular dehydration on the product so as to obtain 6-acetyl-8-cyclopentyl-5-methyl-2-chlorine-8H-pyridino-[2,3-d] pyrimidine-7-ketone, protecting 6 acetyl groups by using carbonyl, further realizing reaction with an aminopyridine derivative so as to obtain 4-{6-[(6-1,1 dialkoxyl) ethyl-8-cyclopentyl-5-methyl-7-keton-7,8 dihydropyridino-[2,3-d]pyrimidine-2-amino]-pyridine-3-yl}-piperazine-1-carboxylic acid tert-butyl ester, and finally performing acid hydrolysis and neutralization to obtain palbociclib free alkali. By adopting the low-cost preparation method, the raw materials are easy to obtain, the cost is low, and the environment can be protected.

The invention relates to a preparation method of palbociclib. The method comprises the following steps: carrying out N-acetoacetylation reaction by using cyclopentylamine and an acetoacetylation agent to obtain N,N-di(acetoacetyl) cyclopentylamine (II), carrying out intramolecular condensation on N,N-di(acetoacetyl) cyclopentylamine (II) in the presence of an alkaline reagent to obtain N-cyclopentyl-3-acetyl-4-methyl-6-hydroxy-2-pyridone (III), enabling N-cyclopentyl-3-acetyl-4-methyl-6-hydroxy-2-pyridone (III) to react with a formylation reagent to prepare N-cyclopentyl-3-acetyl-4-methyl-5-formyl-6-chlorine-2-pyridone (IV), carrying out pyrimidine ring reaction by using N-cyclopentyl-3-acetyl-4-methyl-5-formyl-6-chlorine-2-pyridone (IV) and N-(5-(4-tert-butoxy carbonyl-1-hexahydropyrazinyl)-2-pyridyl) guanidine sulfate (V), and then hydrolyzing under the alkaline condition to prepare palbociclib. The preparation method of palbociclib is easily available in raw materials, short in process, simple and convenient to operate and safe and environmentally friendly in process.

The invention relates to the technical field of lactic acid preparation and particularly relates to a method for preparing lactic acid through catalyzing glycerol by a supported catalyst. According to the method, the selectivity of lactic acid can reach 70-90%, and the conversion ratio of glycerol can reach 72-100%. The method is characterized in that reaction is carried out on glycerol which serves as a raw material in a high-pressure reactor under anaerobic and alkali source provided alkaline conditions in the presence of supported copper oxide which serves as a catalyst, thereby obtaining lactic acid, wherein a support of the supported copper oxide catalyst contains metal oxides, including MgO, ZrO2, TiO2, CeO2 and ZnO, activated charcoal or hydroxyapatite; the supported copper oxide catalyst is easy to prepare, low in cost and relatively long in service life. The method has the advantages that the reaction temperature and reaction pressure are low, the catalyst activity is high, the selectivity is good, the reaction rate is high, and the process flow is safe and environmental-friendly and the like, so that the industrial prospect is good.

The invention discloses normal temperature calcium-manganese phosphorizing liquid, which comprises Mn<2+>, Ca<2+> and sodium benzoate or benzoic acid or nickel nitrate. The environment-friendly calcium-manganese phosphorizing liquid provided by the invention can be used at normal temperature, and has the advantages of no surface adjusting process before phosphorizing and no washing process after phosphorizing, simple operation, long service life and excellent effect, when the generated phosphorizing membrane is taken as a coating basement, the coating has good adhesive force, thereby overcoming the problems of complicated conventional phosphorizing process, higher phosphorizing liquid temperature, large consumption of water and phosphate, much harmful wastewater and the like. The phosphorizing liquid is suitable for surface treatment before coating the surface of black metal steel, and the generated phosphorizing film is used as a basement of the coating.

An improved process for the preparation of acyl aromatic ethers useful as important intermediates for drugs and pharmaceuticals by reacting an aromatic ether with an acylating agent selected from a C2-C8 acid anhydrides, employing nano- and microcrystalline zeolite beta as catalyst is disclosed.

The invention belongs to the treatment technical field of decanedioic acid produced waste water, and particularly relates to a treatment method of waste water produced by adopting castor oil to prepare decanedioic acid, which adopts the technical scheme that: scrap iron is firstly added into an oxidation pond to form a stationary bed layer of solids; then the waste water with the solid foreign matters being filtered is discharged into the oxidation pond, and simultaneously the hydrogen dioxide solution oxidant with the concentration of 30 percent is added to the oxidation pond; air is sent into the oxidation pond through a blower; finally sulfuric acid is added into the oxidation pond to adjust the pH value to be 3 to 4, three-phase catalytic oxidation reaction is carried out, the active ingredient of catalyst is green copperas, the reaction temperature is 50 DEG C to 60 DEG C, and the reaction time is 4h to 8h; and after the reaction is ended, the waste water after being treated is discharged into a waste water adjusting pond, flocculating agent is also added into the waste water adjusting pond, and the well-treated waste water can be obtained after filtering the suspended substances and precipitates The method has simple process and moderate reaction conditions, is free from requiring the high temperature and high pressure, is easy to operate, has fast reaction speed, less equipment investment, high treatment efficiency, high removal rate of phenol in the waste water and no secondary pollution, and is environment-friendly and safe.

The invention provides a preparation method of mesotrione. The preparation method comprises the following steps: taking p-methylsulfonyl o-nitrobenzoic acid as a raw material; after carrying out acylchlorination, carrying out condensation reaction with 1,3-cyclohexanedione to obtain an intermediate 2-nitryl-4-methylsulfonylbenzoic acid-[3'-carbonyl-1'-cyclohexenol]-ester; then carrying out rearrangement of enol ester under a common catalysis effect of inorganic alkali and tertiary amine type organic alkali with relatively strong basicity, so as to obtain an acrylated cyclic 1,3-dicarbonyl compound mesotrione. According to the method provided by the invention, a virulent cyanide catalyst is not used, the reaction temperature is relatively low and the reaction time is short; a solvent can be cyclically used, the total mol yield of a prepared mesotrione product can reach 95 percent and the content is 98.5 percent; the technology is safe and environmentally friendly, has a small amount ofthree wastes and is suitable for industrial production.

The invention discloses a sludge treatment process which comprises the following steps: (1) sterilizing sludge so as to kill microorganisms in the sludge; (2) dewatering and drying the sterilized sludge so as to reduce the water content of the sludge; (3) separating the dried sludge, carrying out high temperature plasma treatment on the separated sludge, and burning separated smoke; (4) carrying out sludge-smoke separation on smoke generated by reburning treatment, carrying out high temperature plasma treatment on the separated sludge again, and purifying and cooling the separated smoke. The invention further discloses a sludge treatment system capable of carrying out the sludge treatment process. The sludge treatment system comprises a sterilizing device, a dewatering device, a drying device, a plasma gasifying or plasma vitrifying device and a purifying device. The sludge treatment system can realize harmless, reducing and resourceful treatment for the sludge and does not generate secondary pollution, is safe and reliable, and can realize thorough treatment for the sludge.

The present invention relates to a technique for producing a cathode film having a thin and even thickness and having stable electrical characteristics at a high productivity by an extrusion molding method. That is, the present invention provides an active material for a cathode film comprising a lithium compound having a void fraction of 0.36 or less and a polyether polymer composition for a cathode film comprising a polyether polymer, an electrolytic salt compound which is soluble in the above polymer and the active material for a cathode film described above. The object described above can be achieved by extrusion-molding them.

The invention relates to a method for manufacturing a mud-rock sample by adopting white oil as a refrigerant. The method is characterized by comprising the steps of (1) drilling a mud rock sample column, namely (a) for mud cock and the mud cock with cracks, using the white oil as the refrigerant, and (b) drilling the mud rock sample column by adopting a common vertical rock sample drilling machine; (2) encapsulating a rock core column, namely (a) taking out the rock core column, putting the rock core column into heated absolute ethyl alcohol, and washing off the white oil on the surface and gaps of the rock core column, (b) sheathing a thermal shrinkable sleeve in time, and (c) baking the rock core column and the thermal shrinkage sleeve on an alcohol lamp simultaneously till the rock core column is tightly fastened by the thermal shrinkable sleeve; and (3) cutting a sample according to the permeability, namely (a) cutting the overlong rock core column of the mud rock and the thermal shrinkable sleeve on an end-surface cutting machine, wherein consistent length and permeability are required. The method has the advantages that the success rate of the sample can be increased, the rock core sample meeting the requirements can be processed, the environment-friendly effect is achieved and the labor efficiency is high.

The invention discloses a grease decoloring agent, relates to a purification and adsorption material, and especially relates to the grease decoloring agent of aluminum-based hydrate composite materials and a preparation method thereof. The grease decoloring agent is characterized by being prepared by selecting two or more than two aluminum-based hydrates having the adsorption property, carrying out mixing homogenization and then adding an acidic modifying agent for modification and activation. The grease decoloring agent is a mixture of the aluminum-based hydrate composite materials. The materials have the advantages of less using amount, good decoloring effect, easy filtration and separation, small residual oil rate and the like; moreover, the decolorizing agent does not contaminate products; after medium temperature roasting after decolorization, the decolorizing agent can be used in a raw material of a high temperature coating layer material, thereby reducing the decoloring agent cost; and the grease decoloring agent fully meets the requirements of food-grade grease on indicators of the chromaticity and the impurity content, and is easy to popularize and apply.

The invention discloses a multi-microelement enriched herba rhodiolae cultivation method. The method comprises a series of steps of soil preparation and sowing, field management, disease and pest prevention and harvesting at an appropriate timing. According to the method, by the combined application of a nutrient solution and a foliar fertilizer, the cultivation process is safe and environmentallyfriendly, the absorbing of each nutritious ingredient of herba rhodiolae plants can be effectively promoted, and the growth of the plants is promoted, so that the plants are rich in multiple kinds ofmicroelements to expand the medical functional potential of herba rhodiolae.

The invention provides an acetoin synthesis method. The method comprises 1, catalyst preparation: mixing 4-methyl-5-beta-hydroxyethyl thiazole (I) and bromoethane according to a mole ratio of 1: 1, carrying out heating reflux in an acetoin solvent in an oil bath for a reaction, then carrying out stirring cooling to the room temperature, carrying out rotary evaporation, recovering the solvent, standing the white precipitates, carrying out suction filtration and washing, carrying out acetoin recrystallization and carrying out drying to obtain a catalyst 3-ethyl-4-methyl-5-hydroxyethyl thiazole bromide (II) and 2, carrying out acetaldehyde condensation to obtain acetoin, adding the catalyst 3-ethyl-4-methyl-5-hydroxyethyl thiazole bromide (II) into an acetaldehyde solution, adjusting pH to 9-10, carrying out heating stirring for a condensation reaction in a pressure reactor until the pressure in the pressure reactor is 0 MPa, mixing the reaction solution, the recovered solvent and solutions collected in standing, suction filtration and washing processes, and carrying out reduced pressure distillation to obtain acetoin (III).

The invention discloses a synthesis method for 1-chloro-1-acetyl cyclopropane. The synthesis method is characterized in that 3,5-dichloro-2-pentanone is taken as a raw material, and solvent oil is taken as a solvent to react with a 20% sodium hydroxide aqueous solution under action of a phase transfer catalyst crown ether, fluid separation and distillation can be performed to separate out 1-chloro-1-acetyl cyclopropane. Solvent oil which does not react with a system is added as the solvent, so that reaction is performed in two phases, and therefore, contact time between a product and alkalineis reduced, product purity is improved, and the yield is improved more greatly. Raw material reaction speed can be increased by adding the phase transfer catalyst, separation speed of the product anda water phase in a post-treatment process is quickened by adding the solvent, and dwell time, in the reaction system, of raw materials and product is integrally shortened, so that side reaction is reduced, and selectivity is improved.