10results about How to "Prevent purity" patented technology

The invention belongs to the technical field of gas separation, and particularly relates to a zero-gas-consumption PSA (Pressure Swing Adsorption) air separation nitrogen-making device which comprises an adsorption tower, a top cover, a gas outlet pipe, a gas inlet pipe and an electromagnetic valve, the protection mechanism is arranged at the joint of the adsorption tower and the top cover; the back flushing mechanism is arranged at the upper end of the adsorption tower; the blocking mechanism comprises a blocking part arranged in the air outlet pipe, an abutting part is arranged on the blocking part, an adjusting part is arranged on the abutting part, and the pressure generated by the abutting part on the blocking part is adjusted by twisting the adjusting part; wherein the protection mechanism comprises an outer shell, the outer shell is composed of two shell bodies, reinforcing parts are annularly distributed in the outer shell, and warning parts and linkage parts are arranged on the reinforcing parts. According to the invention, a high-efficiency zero-gas-consumption air separation nitrogen production process can be realized; and meanwhile, good safety protection measures are taken, and the situation of gas leakage is reduced.

The invention belongs to the technical field of cell culture, and particularly relates to a culture method for in-vitro amplification of NK cells activated by NK cell exosomes, which comprises the following steps of: after promoting the NK cells to generate a large amount of exosomes by using an electrical stimulation method, filtering, performing ultrafiltration, extracting and purifying the NK cell exosomes by using specific immunomagnetic beads, thereby obtaining the NK cell exosomes activated by the NK cell exosomes. A set of strict detection and quantification standards is established for the exosome by utilizing Western Blot, a BCA method, DLS and NTA technical means, a primary PBMC is obtained by adopting a density gradient centrifugation method, and the high-activity and high-purity NK cell exosome is dynamically added into a cell culture medium in the activation and amplification stages of the PBMC, so that self-activation of the NK cells is realized, the proliferation efficiency of the NK cells is remarkably improved, and the NK cell exosome has a good application prospect. Meanwhile, the safety risk of a culture system is reduced.

The invention belongs to the technical field of synthesis of chemical intermediates, and particularly relates to a system and a method for continuously preparing phosphorus oxybromide. According to the system provided by the invention, through continuous preparation design, continuous production of phosphorus oxybromide can be realized, the preparation efficiency is improved, and the problem that the product yield and purity are reduced due to long-time high-temperature separation is avoided. Phosphorus tribromide is used as a raw material, trichloromethane is used as a solvent, the phosphorus tribromide and the trichloromethane are mixed to obtain a mixed solution, the mixed solution enters the reaction tower and is in contact with a mixed gas of nitrogen dioxide and oxygen entering the reaction tower, phosphorus tribromide is oxidized into phosphorus oxybromide, nitrogen dioxide and residual oxygen are recycled from the top of the reaction tower, waste gas emission is reduced, and the production cost is reduced. The mixed solution of trichloromethane and phosphorus oxybromide firstly passes through the falling film evaporator to evaporate most of the solvent, and then passes through the scraper film evaporator to evaporate the residual solvent, so that the solvent is recycled, the energy consumption is reduced, the time of the phosphorus oxybromide staying in the evaporator is reduced, and the yield and purity of the phosphorus oxybromide are improved.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of crotamiton and an external preparation applied by the crotamiton. Comprising the following steps: step 1, slowly dropwise adding 2-butenoyl chloride into N-ethyl-o-toluidine, and controlling the reaction temperature at 10-30 DEG C; after the reaction is finished, heating to 45-55 DEG C, and reacting for 2-4 hours to obtain a product A; adding purified water for dilution, adding a demulsifier, and adding ethyl acetate for extraction to obtain an organic phase; 2, washing the organic phase with a hydrochloric acid solution and a sodium hydroxide solution in sequence, performing liquid separation, performing reduced pressure distillation, collecting fractions at the temperature of 152-155 DEG C and the pressure of-0.096 to-0.1 Mpa, performing refined filtration with a 0.2-0.24 [mu] m filter element in sequence, performing filling, performing capping, and performing packaging; and thus, the crotamiton is obtained. And preparing a medicine solution from crotamiton and other substances, and combining the medicine solution with the pre-gel solution to obtain the external preparation of crotamiton.

The application discloses a method for continuously preparing high-purity sulfolane, and belongs to the technical field of organic synthesis. By introducing a solvent and a stable free radical type polymerization inhibitor, the self-polymerization of butadiene is effectively inhibited. By adopting a cooling crystallization mode to remove sulfur dioxide, the thermal decomposition of sulfolene sulfone is avoided, high yield and high purity are realized, the service life of a hydrogenation catalyst is not affected, and the catalyst can be completely reused. The cooling crystallization also realizes the separation of the polymerization inhibitor and sulfolene sulfone. The polymerization inhibitor is dissolved in the solvent and recycled, and does not enter the hydrogenation system, so that the final sulfolane product has a purity of above 99.9% and has no chromaticity problem. The process saves energy consumption, the solvent has wide universality, operation is simple, the process is safe and environment-friendly, easy to scale up, and meets the green production requirements.

This invention relates to a method for purifying amino acids from an initial mixture, wherein the amino acids comprise an aromatic ring and have an acidity constant Ka, the method comprising: - a first step: contacting the initial mixture with a strong cation exchange resin at a pH greater than or equal to pKa; - a second step: eluting with an aqueous solution of an eluent with a pH greater than that of the first step, thereby allowing the collection of an amino acid-rich fluid.

The application discloses a noise label robust training method and device for an image recognition model, and belongs to the technical field of image recognition model training, and comprises the following steps: inputting image training samples into a deep neural network for feature extraction; constructing a multi-granularity granular ball structure in a feature space based on a feature vector; performing hierarchical correction on the labels of the image training samples; performing label propagation in the granular ball, and calculating the propagation confidence distribution and consistency score of each image sample; screening a clean sample subset according to the consistency score, and iteratively training the deep neural network to update network parameters. Through the adaptive multi-granularity granular ball division mechanism, the application can fully depict the local structure characteristics of data in the feature space, avoid the problems of excessive fragmentation or insufficient purity caused by traditional fixed-granularity clustering in a high-noise environment, and provide a stable and reliable structure prior for subsequent label correction and information propagation.

This invention discloses a catalytic synthesis method for 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2-( 5H A method for reacting 1-arylmethyl-4-arylmethylenepyrrole-2,3-dione compounds and diethyl phosphonate in an organic solvent under the presence of a base catalyst undergoes a Michael addition and a 1,4-P-Brook rearrangement tandem reaction. Sodium ethoxide is then added for hydrolysis to yield 1-arylmethyl-4-arylmethyl-3-hydroxypyrrole-2,3-dione compounds and their derivatives. 5H )-ketone. This invention achieves 3-hydroxypyrrole-2-( )-ketone in one step through a series of reactions in a one-pot reaction mode. 5H Alkylation of ketones at the C(4) position: The catalyst used is mild and readily available, enabling highly efficient catalytic reactions with good yields of the target product. It is both economical and environmentally friendly, making it suitable for large-scale applications.

The invention relates to the field of cinnamyl aldehyde preparation, and particularly discloses a cinnamyl aldehyde purification device and method, and the purification device is used for purifying cinnamyl aldehyde with cinnamon leaves as a raw material. Comprising. The reaction kettle is used for forming a reaction chamber in a vacuum state; the heating piece is arranged in the reaction chamber, and the heating piece and the reaction chamber form a spiral cavity channel used for containing the cinnamon leaves in a high-temperature state; and the driving piece is used for driving the heating piece to rotate, so that the spiral cavity channel rotates and drives the cinnamon leaves to move in the spiral cavity channel. The device has the advantages that the spiral cavity channel formed by the spiral plate is used for conveying the cinnamon leaves, the cinnamon leaves are in a moving state in the reaction kettle, then the spiral cavity channel heats the cinnamon leaves in a contact mode, the heating area of the cinnamon leaves is increased, and the heating area is further increased due to conveying of the cinnamon leaves and rolling of the cinnamon leaves.

The present invention relates to the technical field of catalysts, and discloses a 1, 5-cyclooctadiene iridium chloride dimer catalyst preparation method, which comprises: (1) adding an iridium precursor to an alcohol, adding a hydrochloric acid solution, adding 1, 5-cyclooctadiene while carrying out a heating stirring reaction, and filtering after the reaction to obtain a 1, 5-cyclooctadiene iridium dichlorohydride dimer; and (2) adding the 1, 5-cyclooctadiene iridium dichlorohydride dimer into water, then adding an alkaline substance and alcohol, carrying out a stirring reaction under the assistance of ultrasonic waves, and filtering after the reaction to obtain the 1, 5-cyclooctadiene iridium chloride dimer. According to the method, the hydrochloric acid is added to enable the reaction to be carried out in the direction of generating the intermediate product, the obtained intermediate product and the alkaline substance are subjected to the dehydrochlorination reaction, the reaction time can be shortened under the action of ultrasonic waves, and finally the high-purity 1, 5-cyclooctadiene iridium chloride dimer can be obtained at a relatively high yield.