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Composition containing collagen and preparation method of composition containing collagen

A collagen and composition technology, applied in the field of collagen-containing composition and its preparation, can solve the problems of poor compliance of collagen peptides, astringent taste of collagen peptides, poor taste, etc., and achieve easy absorption, convenient administration, Avoid bad taste effects

Inactive Publication Date: 2018-05-25
BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen peptides with small molecular weights (especially those with a molecular weight less than 1000 Daltons) have astringent taste and poor taste, and the direct oral administration of small molecule collagen peptides has poor compliance, so the preparation of solid preparations of small molecule collagen is not an ideal solution.

Method used

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  • Composition containing collagen and preparation method of composition containing collagen
  • Composition containing collagen and preparation method of composition containing collagen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Prescription

[0034] 15 grams of non-denatured type II collagen, 785 grams of type I collagen, 50 grams of papaya enzyme, 605 grams of sorbitol, 15 grams of stearic acid, 9 grams of hydroxypropyl methylcellulose, 1.2 grams of vinylpyrrolidone, and 2.3 grams of glycerin gram, Tween 1.2g, titanium dioxide 0.8g, pigment 0.6g

[0035] 2. Preparation method

[0036] Weigh non-denatured type II collagen, type I collagen, papain, sorbitol, and stearic acid according to the formula and mix them evenly, place the mixture in a tablet machine, adjust the tablet weight to 1.5 grams, and then directly compress the tablet. Then the tablet is coated (the coating material is composed of hydroxypropyl methylcellulose, vinylpyrrolidone, glycerin, Tween, titanium dioxide, and pigment).

Embodiment 2

[0038] 1. Prescription

[0039] Denatured Type II Collagen 30g, Mango Enzyme 100g, Aloe Vera Enzyme 200g, Lactose 50g, Stearic Acid 10g

[0040] 2. Preparation method

[0041] Pass the denatured type II collagen, mango enzyme, aloe enzyme, and sorbitol through an 80-mesh sieve, weigh the sieved raw materials according to the formula, put the weighed raw materials into a wet granulator container, mix them evenly, and spray 30% ethanol aqueous solution (the amount of ethanol aqueous solution is 10% of the amount of solid raw materials), while the material is vigorously stirred and chopped into particles by a cutting knife. The granules are sent to a granulator to crush oversized agglomerates, passed through a 20-mesh sieve, and then dried to obtain granules. Then the granules and stearic acid are mixed, and the tablet weight of the tablet press is adjusted to 2 grams, and the tablets are directly compressed.

Embodiment 3

[0043] 1. Prescription

[0044] Type III collagen 1200g, apple enzyme 50g, wormwood enzyme 200g, sorbitol 605g, caramel coloring 80g

[0045] 2. Preparation method

[0046] Pass type III collagen, apple enzyme, wormwood enzyme, sorbitol, stearic acid, and caramel color through an 80-mesh sieve. The sieved raw materials were weighed and mixed evenly to obtain a solid powder.

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Abstract

The invention relates to a composition containing collagen and a preparation method of the composition containing collagen, and belongs to the field of drugs and health-care products. The compositioncontaining collagen basically consists of 15-1200 parts by weight of collagen, 50-1000 parts by weight of ferment, 200-900 parts by weight of an excipient and 5-30 parts by weight of a lubricant, wherein the excipient is selected from one or more of sorbitol, mannitol, lactose and soluble starch; and the lubricant is selected from one or more of stearic acid, micronization poloxamer, sodium stearyl fumarate, magnesium stearate, talcum powder, micro powder silica gel, silicon dioxide, PEG6000, sodium fumarate, magnesium laurylsulfate and sldium lauryl sulfate. The composition disclosed by the invention is prepared into a solid preparation rather than a liquid preparation, so that the situation that the collagen existing in a liquid preparation formulation is invalid and degraded during long-term storage is avoided, and collagen products in a solid preparation formulation have the advantage of being convenient to store, transport, carry and take.

Description

technical field [0001] The invention relates to a collagen-containing composition and a preparation method thereof, which belong to the fields of medicines and health care products. Background technique [0002] Collagen is a very important protein in the human body. It widely exists in the skin, bones, muscles, cartilage, joints, and hair tissues of the human body. It mainly exists in connective tissue. It has triple anti-aging functions of support, repair, and protection for the human body. effect. Collagen is a high-molecular protein, which is arranged and combined in a specific form. Filamentous collagen fibers interweave with elastin and polysaccharide proteins to form a network structure of extracellular matrix, which produces a certain mechanical strength and is the support for the human body. Curves reflect the material basis of tall and straight body and healthy skin. Collagen has a strong ability to stretch and is the main component of ligaments and muscle bonds....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/17A23L33/10
CPCA23L33/10A23L33/17A23V2002/00A23V2200/30A23V2250/5422A23V2250/642A23V2250/1634A23V2250/1886A23V2250/51088A23V2250/6406A23V2250/612A23V2250/628A23V2250/5118A23V2250/2112A23V2250/262A23V2250/6418A23V2250/246
Inventor 寇爽韩闪闪佘佐彦
Owner BEIJING KANGLIJI BIOLOGICAL TECH CO LTD
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