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Chitosan-based hemostatic material and preparation method thereof

A hemostatic material, chitosan technology, applied in the field of medical materials, can solve the problem of limited hemostatic effect, achieve good anti-adhesion effect, simple preparation method, and convenient use

Inactive Publication Date: 2016-06-01
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as far as chitosan itself is concerned, its hemostatic effect is very limited, so the hemostatic performance of the material is mainly improved by modifying chitosan or compounding other materials.

Method used

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  • Chitosan-based hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A chitosan-based hemostatic material prepared from the following raw materials in parts by mass: 40 parts of chitosan, 12 parts of corn starch, 5 parts of whey protein, 5 parts of wheat starch, 5 parts of glucose, and 5 parts of sodium alginate , 10 parts of pectin, 4 parts of lecithin, 4 parts of citric acid, 3 parts of sodium fumarate, 4 parts of sodium chloride, 15 parts of glycerin.

[0021] The preparation method comprises the steps of:

[0022] 1) Mix chitosan, glucose, pectin and polyol evenly, add citric acid, stir evenly, add sodium alginate and sodium fumarate, heat to 65°C and mix for cross-linking reaction for 5 hours;

[0023] 2) Add corn starch, whey protein and wheat starch to a small amount of water to moisten, mix and stir evenly, heat to 50°C, and stir for 40 minutes to obtain a viscous mixture;

[0024] 3) Add the mixture of step 2) and the remaining components into the reaction solution of step 1), continue to stir for 20 minutes, cool down to room ...

Embodiment 2

[0026] A chitosan-based hemostatic material prepared from the following raw materials in parts by mass: 20 parts of chitosan, 8 parts of corn starch, 1 part of whey protein, 2 parts of wheat starch, 1 part of glucose, and 2 parts of sodium alginate , 2 parts of pectin, 1 part of lecithin, 1 part of citric acid, 1 part of sodium fumarate, 1 part of sodium chloride, 8 parts of glycerin.

[0027] The preparation method comprises the steps of:

[0028] 1) Mix chitosan, glucose, pectin and polyol evenly, add citric acid, stir evenly, add sodium alginate and sodium fumarate, heat to 65°C and mix for cross-linking reaction for 5 hours;

[0029] 2) Add corn starch, whey protein and wheat starch to a small amount of water to moisten, mix and stir evenly, heat to 50°C, and stir for 40 minutes to obtain a viscous mixture;

[0030] 3) Add the mixture of step 2) and the remaining components into the reaction solution of step 1), continue to stir for 20 minutes, cool down to room temperatu...

Embodiment 3

[0032] A chitosan-based hemostatic material prepared from the following raw materials in parts by mass: 35 parts of chitosan, 11 parts of corn starch, 4 parts of whey protein, 4 parts of wheat starch, 4 parts of glucose, and 3.8 parts of sodium alginate , 8 parts of pectin, 3 parts of lecithin, 3.4 parts of citric acid, 2.3 parts of sodium fumarate, 3 parts of sodium chloride, 13 parts of ethanol, 5 parts of vitamin C, and 2.3 parts of vitamin E.

[0033] The preparation method comprises the steps of:

[0034] 1) Mix chitosan, glucose, pectin and polyol evenly, add citric acid, stir evenly, add sodium alginate and sodium fumarate, heat to 65°C and mix for cross-linking reaction for 5 hours;

[0035] 2) Add corn starch, whey protein and wheat starch to a small amount of water to moisten, mix and stir evenly, heat to 50°C, and stir for 40 minutes to obtain a viscous mixture;

[0036] 3) Add the mixture of step 2) and the remaining components into the reaction solution of step 1...

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Abstract

The invention discloses a chitosan-based hemostatic material and a preparation method thereof. The chitosan-based hemostatic material is prepared from, by mass, 20-40 parts of chitosan, 8-12 parts of corn starch, 1-5 parts of whey protein, 2-5 parts of wheat starch, 1-5 parts of glucose, 2-5 parts of sodium alginate, 2-10 parts of pectin, 1-4 parts of lecithin, 1-4 parts of citric acid, 1-3 parts of sodium fumarate, 1-4 parts of sodium chloride and 8-15 parts of polyhydric alcohol, wherein polyhydric alcohol adopts ethanol or glycerol, and preferably, 2-6 parts of vitamin C and 1-3 parts of vitamin E are included. The chitosan-based hemostatic material has the advantages that the excellent anti-bacterial, hemostatic and analgesic effects are achieved, defective tissue repairing can be facilitated, the anti-adhesive effect is good, the biocompatibility is achieved, the safety are good, the antigenicity does not exist, use is safe, the preparation method is simple, and use is convenient.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a chitosan-based hemostatic material and a preparation method thereof. Background technique [0002] Excessive blood loss caused by traffic accidents, natural disasters, surgical operations, etc. may lead to death, so the development of a fast and effective hemostatic material has become a topic of great concern to experts and scholars in related fields. At the same time, with the improvement of people's material living conditions, people pay more attention to their own health, so higher requirements are put forward for the applicability and functionality of medical materials. As an excellent medical hemostatic repair tissue engineering scaffold material, not only the usual The hemostatic time is short, the hemostatic effect is good, the wound infection cannot be increased, and the secondary trauma should not occur. The implanted material in the body should also have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00A61L31/04A61L31/14
CPCA61L24/08A61L24/00A61L24/10A61L31/042A61L31/043A61L31/14A61L2300/232A61L2300/252A61L2400/04C08L5/08C08L3/02C08L89/00
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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