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Anti-caking compound carbaspirin calcium powder and preparation method thereof

A technology of compound carbasalate calcium powder and carbasalate calcium, which is applied in anti-inflammatory agents, powder delivery, pharmaceutical formulations, etc., can solve problems affecting drug storage, stability and use performance, and easy moisture absorption and caking, etc., to achieve Inhibits caking phenomenon, ensures drug stability, and has the effect of simple ingredients

Inactive Publication Date: 2018-10-02
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the structural characteristics of carbasalate calcium, it is easy to absorb moisture and agglomerate during storage, which affects the storage, stability and performance of the drug.
However, there are few reports on the anti-caking research of carbasalate calcium

Method used

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  • Anti-caking compound carbaspirin calcium powder and preparation method thereof
  • Anti-caking compound carbaspirin calcium powder and preparation method thereof
  • Anti-caking compound carbaspirin calcium powder and preparation method thereof

Examples

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Embodiment 1

[0010] An anti-caking compound carbasalate calcium powder is composed of the following raw materials in parts by weight: 40-60 parts of carbasalate calcium, 10-45 parts of carrier, and 5-40 parts of anti-caking agent; the carrier is water-soluble Starch, hydroxypropyl cellulose, polyethylene glycol 4000, one or two combinations of polyethylene glycol 6000; the anti-caking agent is sodium lauryl sulfate, sodium tetradecyl sulfate, cetyl One or a combination of sodium octadecyl sulfate and sodium octadecyl fumarate.

[0011] Preferably: the carrier is preferably a combination of hydroxypropyl cellulose and polyethylene glycol 4000; the anti-caking agent is preferably a combination of sodium lauryl sulfate and sodium stearyl fumarate.

[0012] The preferred formula is: 40-60 parts of carbasalate calcium, 10-15 parts of hydroxypropyl cellulose, 10-15 parts of polyethylene glycol 4000, 10-15 parts of sodium lauryl sulfate, octadecyl fuma 10-15 parts of sodium bicarbonate.

[0013...

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Abstract

The invention discloses anti-caking compound carbaspirin calcium powder which is prepared from the following raw materials in parts by weight: 40-60 parts of carbaspirin calcium, 10-45 parts of vectorand 5-40 parts of anti-caking agent; the vector is one or a combination of two of water-soluble starch, hydroxy propyl cellulose, polyethylene glycol 4,000 and polyethylene glycol 6,000; and the anti-caking agent is one or a combination of two of lauryl sodium sulfate, sodium tetradecyl sulfate, sodium cetostearylsulfate and sodium octadecyl fumarate. As for the anti-caking compound carbaspirin calcium powder provided by the invention, the components are simple, raw materials are all commercially available raw materials, are cheap and available and are high in safety, so that the caking phenomenon of carbaspirin calcium is effectively inhibited, the storage performance and the use performance of the carbaspirin calcium are improved, the drug property stability of the carbaspirin calcium is ensured at the same time, and the anti-caking compound carbaspirin calcium powder has great practical value; and in addition, a preparation technology is simple, and simple mixing is needed only.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to an anti-caking compound carbasalate calcium powder and a preparation method thereof. Background technique [0002] Carbasalate calcium (earbasalatecaleium) is an aspirin derivative, and its curative effect is the same as that of aspirin, but it has low side effects, good water solubility, and better drug efficacy and physiological functions, so it has been widely valued. Due to the structural characteristics of carbasalate calcium, it is easy to absorb moisture and agglomerate during storage, which affects the storage, stability and performance of the drug. However, there are few reports on the anti-caking research of carbasalate calcium. Contents of the invention [0003] The present invention aims to overcome the existing technical defects of the above-mentioned technologies, and aims to provide a compound carbapirin calcium powder capabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/222A61K47/20A61K47/12A61P29/00
CPCA61K9/145A61K9/146A61K31/222
Inventor 马沛然李建正王凯李亚娥
Owner ZHENGZHOU HOUYI PHARMA
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