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Functional auxiliary material as well as preparation method and application thereof

A technology of excipients and preparation steps, which is applied in the field of medicine, can solve the problems that cannot be directly applied, and achieve the effects of low cost, improved moisture absorption, and simple preparation methods

Inactive Publication Date: 2013-03-13
苏州艾费堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented composition helps make medicine more effective by making them less harmful when exposed to moisture compared with other methods like adding an antioxidative substance or preserving perishable items such as oxygen sensitive ingredients (like fish). Additionally, this new formulation makes production easier without increasing costs due to its easy manufacturing process at home instead relying on expensive chemicals that require specialized equipment during their formation.

Problems solved by technology

The technical problem addressed by this patented technology relating to improving absorption or retention properties when adding certain substances like sodium sultamfuzum hydrate into liquids containing other ingredients without losing their effectiveness due to poorly dispersing them during production processes.

Method used

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  • Functional auxiliary material as well as preparation method and application thereof
  • Functional auxiliary material as well as preparation method and application thereof
  • Functional auxiliary material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 5g of sodium stearyl fumarate and 10g of copovidone S630 into a beaker, add 2000mL of water, in a water bath at 90°C, mechanically stir to dissolve, spray dry, pass through a No. 9 sieve, and collect the sieved powder , the composite material is obtained. Weigh 5 g of sodium stearyl fumarate and 10 g of copovidone S630 and mix them uniformly to make adjuvant materials. Take compound excipients and mixed excipients respectively, each containing 0.1g of sodium stearyl fumarate, add 200mL of water (25°C), stir for 5min, immediately observe the degree of turbidity and whether there is any drifting foreign matter, the results are shown in Table 1.

[0024] Weigh 5g of sodium stearyl fumarate and 30g of copovidone S630 into a beaker, add 1000mL of water, in a water bath at 90°C, mechanically stir to dissolve, spray dry, pass through a No. 9 sieve, and collect the sieved powder , the composite material is obtained. Weigh 5 g of sodium stearyl fumarate and 30 g of copov...

Embodiment 2

[0032] Weigh 5 g of sodium stearyl fumarate and 50 g of copovidone S630 into a beaker, add 1000 mL of 50% ethanol, stir to dissolve, spray dry, sieve, and collect the sieved powder to obtain a composite material.

Embodiment 3

[0034] Weigh 5 g of sodium stearyl fumarate and 100 g of copovidone S630 into a beaker, add 5000 mL of ethyl acetate, mechanically stir to dissolve, spray dry, sieve, and collect the sieved powder to obtain a composite material.

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Abstract

The invention provides a functional auxiliary material as well as a preparation method thereof. The auxiliary material is prepared by carrying out spray drying on stearoyl sodium fumarate and copovidone, and is used for improving the hygroscopicity of the preparation.

Description

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Claims

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Application Information

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Owner 苏州艾费堂医药科技有限公司
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