9results about How to "Suitable for industrial application" patented technology

This invention provides a fusion protein and a corresponding mRNA delivery system and applications. The amino acid sequence of the fusion protein is shown in SEQ ID NO.1. The mRNA delivery system comprises a cationic polymer, the aforementioned fusion protein, and mRNA. The cationic polymer can encapsulate and protect the negatively charged mRNA by neutralizing it. The 3'UTR terminus of the mRNA binds to the C-terminus of the L7Ae protein in the fusion protein, and the Listeriolysin O terminus of the fusion protein is linked to the N-terminus of the L7Ae protein. This invention also provides the application of the aforementioned fusion protein in the preparation of mRNA delivery systems, and the application of the aforementioned fusion protein or the aforementioned mRNA delivery system in the preparation of mRNA transfection reagents, mRNA drugs, or mRNA vaccines. The novel fusion protein can be prepared in large quantities with high yield and controllable quality. This novel mRNA delivery system has a simpler composition, a simpler preparation process, and lower cost. Moreover, in this novel mRNA delivery system, the mRNA is encapsulated and protected by a cationic polymer (such as protamine), making it more stable.

The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparation. The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic which is formed by combining 3, 5-dihydroxy-4'-pentylbiphenyl and betaine through an intermolecular hydrogen bond, and a preparation method of the 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic. According to the 3, 5-dihydroxyl-4 '-pentylbiphenyl-betaine eutectic and the preparation method thereof, the eutectic is formed by BP and BET, the solubility and the dissolution rate of BP are improved, the application amount of pesticide molecules is reduced, and the 3, 5-dihydroxyl-4'-pentylbiphenyl-betaine eutectic is applied to various plant pathogenic fungi. Results of the embodiment show that the co-crystals formed by BP and BET are combined through hydrogen bonds in a molar ratio of 1: 1, the dissolution effect of the co-crystals is superior to that of the medicine, and the dissolution effect is not affected by the pH environment. Compared with drugs with the same concentration and the drug eutecticum, the drug eutecticum shows the antibacterial activity advantage superior to that of original drug molecules.

The invention provides a preparation method and application of a solid bonding lubricating protective coating for a high-end fastener, and belongs to the technical field of high-temperature protective coatings. The solid adhesive lubricating protective coating comprises the following raw materials in parts by mass: 5-15 parts of a ceramic precursor adhesive; 4-14 parts of a filler; the filler comprises a low-temperature section filler and a high-temperature section filler; 30-60 parts of a dispersion medium; and 0.1-1 part of an auxiliary agent. From a formula design source, namely aiming at core challenges of vibration relaxation, fretting wear, wide-temperature-range service and the like faced by high-end fasteners, the prepared coating is specially used for the fasteners, and the obtained coating realizes unification of strong adhesion, wide-temperature-range effective lubrication and excellent wear resistance and fretting resistance under the synergistic effect of a ceramic precursor adhesive and a filler. The locking torque of the solid bonding lubricating protective coating is 7.9-15 in.lb, and a cracking or falling phenomenon does not occur in a high and low temperature alternating cycle test.

The invention discloses a method for recycling waste lithium batteries to synthesize nanoscale lithium phosphate, which comprises the following steps: calcining and slurrying positive electrode black powder of the waste lithium batteries to obtain slurry, and carrying out acid leaching and impurity removal to obtain pure lithium liquid; and adding a phosphorus salt solution into the pure lithium solution or the concentrated lithium solution obtained by concentrating the pure lithium solution, reacting and concentrating to obtain the nano-scale lithium phosphate. According to the synthesis method disclosed by the invention, the phosphorus salt is prepared into a solution form, and the solid-to-liquid ratio of the phosphorus salt is limited by adopting a specific calculation method, so that not only can lithium phosphate with the purity of 99% or above be synthesized, but also high-activity nanoscale lithium phosphate can be obtained, and the size range of the nanoscale lithium phosphate is less than or equal to 700nm; meanwhile, according to different positive electrode black powder components of the waste lithium batteries, uniform particle size morphology regulation and control can be realized, product stability among different batches is formed, and the method is suitable for large-scale industrial application.

This invention relates to a method for preparing 2',4-dichloro-2-aminodiphenyl ether, belonging to the field of chemical synthesis technology. The preparation method is as follows: S1, m-dinitrobenzene undergoes selective hydrogenation to obtain m-nitroaniline; S2, in a solvent, m-nitroaniline reacts with N-chlorosuccinimide to obtain 2-chloro-5-nitroaniline; S3, 2-chloro-5-nitroaniline, o-nitrophenol, a base, and a solvent undergo a co-heated reaction to obtain 2',4-dinitro-2-aminodiphenyl ether; S4, 2',4-dinitro-2-aminodiphenyl ether is dissolved in a solvent, and FeCl3 solution, sodium chloride, and Oxone are added. The reaction is catalyzed under ultraviolet light to obtain 2',4-dichloro-2-aminodiphenyl ether. The preparation method of this invention uses readily available raw materials, has good reaction efficiency, produces less waste, is cleaner and more environmentally friendly, and has a high conversion rate, making it suitable for industrial application.

The invention provides a preparation method of a non-combustible deep eutectic electrolyte based on LiTFSI-NMF-FEC and a lithium metal battery, and the preparation method comprises the following steps: S1, taking lithium bis (trifluoromethanesulfonimide) (LiTFSI) as a lithium salt and N-methylformamide (NMF) as a hydrogen bond donor, accurately weighing LiTFSI and NMF according to a molar ratio of 1: 4, placing the LiTFSI and NMF in a polytetrafluoroethylene sealed container which is subjected to vacuum drying at 120 DEG C for 8 hours, and in a constant-temperature water bath at 80 + / -2 DEG C, carrying out vacuum drying at 120 DEG C for 8 hours; stirring for 12 + / -1h at 400 + / -50rpm, sampling and observing every 2h during the period to ensure that the system is clear, transparent and free of precipitates, and naturally cooling to 25 + / -2 DEG C to obtain a deep eutectic substrate solution; s2, using fluoroethylene carbonate (FEC) as an SEI regulation and control additive, slowly adding the SEI regulation and control additive into the deep eutectic substrate liquid according to the proportion of 5wt% of the total mass of the electrolyte, stirring at 250 + / -30rpm for 3 + / -0.5 h to ensure that the FEC is uniformly dispersed, and standing for 1.5 + / -0.5 h to remove tiny bubbles, so as to obtain uniform deep eutectic electrolyte slurry; and S3, the deep eutectic electrolyte slurry is subjected to battery assembly in an argon glove box, and the lithium metal battery carrying the target electrolyte is obtained through assembly.

This utility model relates to the technical field of wastewater treatment, specifically a mixed acid recovery device for butanol and octanol condensation wastewater. It includes a stripping tower, a multi-effect evaporator, an extraction tower, a washing tower, an oil-water separator, a dehydration tower, and a butyric acid removal tower. A wastewater pipe is connected to the upper inlet of the stripping tower. The bottom outlet of the multi-effect evaporator is connected to the extraction tower via a second pipe, to which an acid inlet pipe is connected. An extractant pipe is connected to the lower inlet of the extraction tower. A liquid inlet pipe is connected to the upper side of the washing tower. The bottom outlet of the butyric acid removal tower is connected to the extractant pipe via a eighth pipe. This utility model integrates stripping, multi-effect evaporation, acidification, extraction, washing, and distillation, efficiently solving the problem of high-COD wastewater treatment from butanol and octanol condensation, and recovering butyric acid and other carboxylic acids and sodium salts as byproducts. It reduces energy consumption while achieving certain economic benefits and improving resource utilization.

This invention provides a novel crystalline form of valbenazine di-p-toluenesulfonate and its preparation method, as well as its use in the preparation of drugs for treating tardive dyskinesia. The novel crystalline form of valbenazine di-p-toluenesulfonate provided by this invention has significant advantages in terms of stability, hygroscopicity, flowability, raw material purification effect, and dissolution rate. The preparation method of the novel crystalline form has a high product yield, is simple to operate, requires less time, and has low energy consumption, making it more suitable for industrial applications.

The application discloses a system for batch discharging of retired power batteries, and discloses a discharging method using the system for batch discharging of retired power batteries, wherein the system for batch discharging of retired power batteries comprises a discharging tank, a driving mechanism and discharging particles; the discharging process does not need to use a special battery charging and discharging instrument with high price, the discharging particles used in the discharging process can be recycled and reused, the discharging cost is low, the discharging efficiency is high, no secondary waste water, waste gas and waste residue pollution is caused, and the system is safe and environmentally friendly; the positive and negative poles of the battery do not need to be specially connected, the risk of fire caused by local heating of the positive and negative poles of the battery due to poor contact caused by terminal oxidation after long-time use is avoided; through simple mixing of the battery and the discharging particles, the discharging can be realized by using the free conduction effect of the discharging particles, different sizes of power batteries can be compatible and applicable, the whole discharging process is simple and easy to implement, and is suitable for industrial application.