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Application of sodium houttuyfonate to preparation of medicament for treating heart failure and/or arrhythmia

A kind of houttuyniacin sodium, heart failure technology, applied in the direction of drug combination, anhydride/acid/halide active ingredients, cardiovascular system diseases, etc., to achieve the effects of improving systemic circulation and pulmonary circulation congestion, enhancing contractility, and increasing calcium ion concentration

Pending Publication Date: 2018-06-29
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect of houttuyfonate sodium on the contractility of cardiomyocytes and the currents of various ion channels in cardiomyocytes has not been reported.

Method used

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  • Application of sodium houttuyfonate to preparation of medicament for treating heart failure and/or arrhythmia
  • Application of sodium houttuyfonate to preparation of medicament for treating heart failure and/or arrhythmia
  • Application of sodium houttuyfonate to preparation of medicament for treating heart failure and/or arrhythmia

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Experimental program
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Effect test

Embodiment Construction

[0046] In order to verify the technical effect of the present invention, this specific embodiment illustrates the new application of Houttuyfonate Sodium in the field of pharmacy through cell-level research.

[0047] 1 material

[0048] 1.1 Animals

[0049] Healthy adult New Zealand big-eared rabbits, weighing 1.5-2kg, regardless of sex, were provided by the Animal Experiment Center of Wuhan University of Science and Technology.

[0050] 1.2 Main instruments

[0051] EPC10 patch clamp amplifier (Heka Electronic, Germany); visual moving edge detection system (IonOptix, USA); three-dimensional micromanipulator (Sutter, USA); fluorescent inverted microscope (Nikon, Japan); two-step glass microelectrode puller (Japan Narishige Company); constant speed pump (Baoding Shenchen Pump Industry Co., Ltd.).

[0052] 1.3 Drugs and reagents

[0053] Type I collagenase and CsCl were purchased from Gibco Company in the United States; taurine, serum albumin and HEPES were purchased from Ro...

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Abstract

The invention provides application of sodium houttuyfonate to preparation of a medicament for treating heart failure and / or arrhythmia. The invention also provides application of the sodium houttuyfonate to preparation of a medicament for enhancing contractile force of ventricular myocytes. The sodium houttuyfonate increases L-type calcium current (Ica.L), and can improve myocardial systolic dysfunction caused by the reduction of sarcoplasmic reticulum Ca release when the heart failure is occurred. The sodium houttuyfonate blocks peak sodium current (Ina.p) and has the characteristics of class-I antiarrhythmic medicaments, and can also block late sodium current (INa.L) increased by the induction of congestin II (ATX-II) and has the potential of inhibiting the arrhythmia caused by the increment of the INa.L.

Description

technical field [0001] The invention belongs to the technical field of houttuyfonate sodium, and specifically relates to the application of houttuyfonate sodium in the preparation of medicines for treating heart failure and arrhythmia. Background technique [0002] Heart failure, referred to as heart failure, refers to the failure of the venous blood to fully discharge the heart due to cardiac systolic and / or diastolic dysfunction, resulting in blood stasis in the venous system and insufficient blood perfusion in the arterial system, resulting in cardiac circulation syndrome. , This kind of disorder symptom group manifests as pulmonary congestion and vena cava congestion. Heart failure is not an independent disease, but the end stage of the development of heart disease. Almost all cardiovascular diseases will eventually lead to heart failure. Myocardial injury caused by any reason such as myocardial infarction, cardiomyopathy, hemodynamic overload, inflammation, etc., can c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61P9/04A61P9/06
CPCA61K31/185
Inventor 马季骅曹珍珍张培华张培培刘志沛田由甲
Owner WUHAN UNIV OF SCI & TECH
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