Temperature-sensitive type gel for curing endometritis of livestock and preparation method for temperature-sensitive type gel

Abstract

The invention belongs to the technical field of veterinary drug preparations, in particular to temperature-sensitive type gel for curing endometritis of livestock and a preparation method for the temperature-sensitive type gel. The temperature-sensitive type gel comprises the following main drug: one of 5 to 10 percent of ofloxacin, 1 to 2 percent of sodium new houtluyfonate, 1 to 2 percent of sodium houttuyfonate, 5 to 20 percent of sulfadiazine sodium, 5 to 20 percent of sulfamonomethoxine sodium and 10 to 20 percent of lincomycin hydrochloride, the following auxiliary materials: 10 to 30 percent of gel matrix, 1 to 2 percent of release rate regulator, 0.1 to 0.5 percent of antioxygen and 0.5 percent of acetic acid, and balance of water for injection in weight percentage. By fully utilizing the characteristics of good flowability, long resistance time, slow drug release and lasting and stable drug effect of the temperature-sensitive type gel disclosed by the invention, the endometritis of the female livestock is effectively cured, and the curative effect is thorough; meanwhile, the labor strength of a cultivation worker is reduced; the temperature-sensitive type gel is more convenient in therapeutic use.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a temperature-sensitive gel for treating livestock endometritis with good fluidity, long residence time, slow drug release and long-lasting and stable drug effect and a preparation method thereof. Background technique [0002] With the rapid development of the livestock breeding industry, the application of veterinary drugs in the breeding field is becoming more and more common. Female livestock, as a key link in the breeding production process, plays a decisive role in the breeding benefits. Female domestic animal endometritis is a common reproductive organ disease in female livestock. The disease occurs mostly during childbirth and postpartum. Due to dystocia, retained placenta, uterine prolapse, unclean operation during midwifery, and rough operation, it causes uterine damage and postpartum infection; In addition, artificial insemination is not...

AI Technical Summary

Problems solved by technology

The existing treatment methods are mainly divided into local therapy and systemic therapy. Local therapy is to fully flush the uterus with 1% saline or 0.02% bromogeramine solution in the acute postpartum period, so as to remove the inflammatory secretions accumulated in the uterus, so as to achieve The effect of sterilization and disinfection, however, this method has a disadvantage, that is, the time to maintain the bactericidal effect is short after flushing, and the liquid is discharged after flushing, and the sanitary conditions of livestock pens are poor, and it is easy to relapse infection, which requires repeated flushing, and the labor intensity of breeding workers Larger, at the same time the treatment is not thorough, it is easy to turn acute endometritis into chronic endometritis; systemic therapy can be treated with antibiotics, mainly intramuscular injection, due to the special structure of the uterus, it is difficult for the drug to reach the affected part, so the therapeutic effect far from ideal

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