Sodium houttuyfonate tablets and preparation method thereof

A houttuyfonate sodium and tabletting technology, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of difficult dissolution, low bioavailability, and poor curative effect, and achieve good taste, Improve drug stability and fast absorption effect

Active Publication Date: 2016-05-25
GUANGZHOU YIPINHONG PHARMA +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The capsule dosage form effectively masks the peculiar smell of houttuyfonate sodium, but after taking it, it is difficult to dissolve, resulting in low bioavailability and poor curative effect

Method used

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  • Sodium houttuyfonate tablets and preparation method thereof
  • Sodium houttuyfonate tablets and preparation method thereof
  • Sodium houttuyfonate tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation:

[0033] (1) Ethyl cellulose and hydroxypropyl cellulose are dissolved in an appropriate amount of ethanol to obtain a coating suspension;

[0034] (2) Sieve 60-80 mesh houttuyfonate sodium, add it to the fluidized bed, spray the coating suspension prepared in step (1) into the coating by bottom spray coating method, and obtain houttuyfonate sodium Microcapsules;

[0035] (3) Sieve houttuyfonate sodium microcapsules of 30-60 meshes, mix them evenly with microcrystalline cellulose, lactose, magnesium stearate, and sucralose, and press into tablets to obtain the product.

Embodiment 2

[0037]

[0038] Preparation:

[0039] (1) Ethyl cellulose and hydroxypropyl cellulose are dissolved in an appropriate amount of ethanol to obtain a coating suspension;

[0040] (2) Sieve 60-80 mesh houttuyfonate sodium, add it to the fluidized bed, spray the coating suspension prepared in step (1) into the coating by bottom spray coating method, and obtain houttuyfonate sodium Microcapsules;

[0041] (3) Sieve houttuyfonate sodium microcapsules of 30-60 meshes, mix them evenly with microcrystalline cellulose, lactose, magnesium stearate, and sucralose, and press into tablets to obtain the product.

Embodiment 3

[0043]

[0044] Preparation:

[0045] (1) Dissolving ethyl cellulose in an appropriate amount of ethanol to obtain a coating suspension;

[0046] (2) Sieve 60-80 mesh houttuyfonate sodium, add it to the fluidized bed, spray the coating suspension prepared in step (1) into the coating by bottom spray coating method, and obtain houttuyfonate sodium Microcapsules;

[0047] (3) Sieve houttuyfonate sodium microcapsules of 30-60 meshes, mix with mannitol, croscarmellose sodium, silicon dioxide, and sodium saccharin evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention provides sodium houttuyfonate dispersible tablets. The sodium houttuyfonate dispersible tablets are prepared by uniformly mixing coating micro-capsules of sodium houttuyfonate with other pharmaceutically acceptable adjuvant materials prior to tableting.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a houttuyfonate sodium dispersible tablet and a preparation method thereof. Background technique [0002] Houttuyfonate Sodium, also known as Houttuyniatin, is a sodium bisulfite adduct of decanoyl acetaldehyde, which is the first effective antibacterial and anti-inflammatory drug used in clinical practice in my country (Zheng Junmin et al. Research on crystal form and bioavailability, Journal of Shenyang Pharmaceutical University, 1981, total 13). Houttuyfotin sodium has obvious inhibitory effect on catarrhal bacteria, influenza bacillus, pneumococcus, and staphylococcus aureus, and has obvious effects of antagonizing inflammatory exudation and tissue edema in the early stage of inflammation, and inhibiting inflammatory pain response, especially for Treatment of cervical erosion. [0003] However, houttuyfonate sodium is a white or off-white need...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/185A61K47/38A61P11/00A61P15/00A61P31/04
CPCA61K9/2081A61K31/185A61K47/38
Inventor 李捍雄杨冬玲佟妍
Owner GUANGZHOU YIPINHONG PHARMA
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