26 results about "Phenylmethanol" patented technology

The invention discloses a method for detecting related substances in imaric acid dihydrochloride by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy, the related substances in the imaric acid dihydrochloride are detected by high performance liquid chromatography, a phosphate buffer solution (0.05 mol / L of monopotassium phosphate solution, and pH adjusted to 2.5 by phosphoric acid) is used as a mobile phase A, acetonitrile is used as a mobile phase B, gradient elution is carried out, the flow rate is 1.0 ml / min, the detection wavelength is 250nm, and the detection wavelength is 250nm. The column temperature is 40 DEG C, and the detection wavelength is 235nm; the method can be used for effectively separating and quantitatively detecting imatamide, demethylated imaric acid dihydrochloride, ortho-imaric acid, meta-imaric acid, p-hydroxymethyl benzamide, an intermediate B, p-hydroxymethyl benzoic acid, an imaric acid dimer, p-cyanobenzyl alcohol, p-chloromethyl benzamide, p-toluic acid and p-chloromethyl benzoic acid in the imaric acid dihydrochloride. The method disclosed by the invention is simple and convenient to operate, strong in specificity, high in sensitivity and accuracy, good in linearity and capable of effectively controlling the quality of a p-imaric acid dihydrochloride product.

The invention discloses a method for preparing a chiral benzhydrol compound through asymmetric hydrogenation of o-amido benzophenone under catalysis of rhodium. The chiral rhodium catalyst is generated in situ from a metal rhodium salt and a chiral phosphine-phosphoramidite ligand in various solvents. Compared with other methods for synthesizing chiral benzhydrol, the method has the characteristics of cheap catalyst, easiness in preparation of chiral ligand, mild reaction conditions, simplicity and convenience in operation, high yield, high enantioselectivity and the like, and can be applied to large-scale preparation of chiral benzhydrol compounds. The method is also suitable for efficient preparation of the rice plant growth regulation inhibitor (S)-Inabenide, the yield can reach 92%, the enantioselectivity can reach 96%, and the method has good industrial application prospects.

The present invention provides an electrochromic material, preparation method, and application for monitoring battery health. Taking the total mass fraction as 100%, the electrochromic material comprises ethoxylated bisphenol A dimethacrylate, tripropylene glycol diacrylate, isobornyl methacrylate, 4-diphenylmethanol methacrylate, 4-acryloylmorpholine, an antioxidant, a photoinitiator, and an electrochromic polymer, wherein the electrochromic polymer is a metal complex of a pyridine derivative. The electrochromic polymer provided by the present invention can rapidly react under the action of light or electricity, causing the color of the material to change from transparent to colored. This allows for continuous monitoring of battery leakage, enabling timely detection of battery leakage problems through electrochromism and prompt replacement of problematic battery modules, thereby facilitating maintenance and servicing of battery equipment.

The application discloses a polysilsesquioxane / polyether ether ketone composite film, a preparation method thereof and application of the composite film in separation of organic mixed solvents, and aims at the problem of depositing a defect-free polysilsesquioxane hybrid film on a polymer substrate in a large area. A film material is prepared by taking 1,2-di(triethoxysilyl)ethane polysilsesquioxane precursor as raw material, a new film preparation method is provided, and the processing technology is designed and optimized from the aspects of simplicity of the film preparation technology, industrialization of the film separation technology and improvement of the film preparation efficiency. The film preparation efficiency is improved, and the film also has certain separation performance, and has excellent effects on separation and recovery of methanol / toluene and methanol / dimethyl carbonate.

A benzotriazole-modified anti-sagging resin, a preparation method therefor, and a coating. The raw materials of the modified anti-sagging resin, calculated by parts by weight, comprise the following components: 60-80 parts of a polymer resin; 5-20 parts of a solvent; 1-3 parts of one or more mixed diisocyanates; and 1-4 parts of benzotriazole containing a primary amine group. The preparation method comprises: S1: mixing a primary amine diphenylmethanol with a portion of the solvent, to prepare a primary amine diphenylmethanol solution of a preset concentration; S2: mixing the polymer resin and the remaining solvent uniformly in a reaction kettle with continuous stirring, maintaining the reaction system temperature at 0-40°C, dispersing the primary amine diphenylmethanol solution prepared in step S1 into the reaction system, adding the diisocyanate(s), and stirring, to obtain the modified anti-sagging resin. By means of a benzotriazole-based UV absorber present in the form of polyurea crystals, the risk of volatilization and incompatibility with a coating are avoided, and this can also enhance the aging resistance of the anti-sagging resin.

The present invention relates to the field of packaging technology, and discloses an anti-deformation paper packaging box and a manufacturing process thereof. Modified tannic acid is prepared using tannic acid, undecylenyl chloride, and chloroprene rubber. The chloroprene rubber helps to improve heat resistance and weather resistance, and the long aliphatic carbon chain of undecylenyl chloride can have a toughening effect. An isocyanate-terminated prepolymer with good water resistance is prepared using polytetrahydrofuran diol and diphenylmethane diisocyanate as raw materials. The prepolymer is connected to the modified tannic acid using 2-mercaptobenzyl alcohol and a photoinitiator to obtain a base material, and then asphalt with good waterproof performance is added. The isocyanate groups in the base material can modify the asphalt, improving the mechanical strength, water resistance, and temperature sensitivity of the asphalt, ultimately producing a waterproof adhesive with good water resistance and good flexibility. The waterproof adhesive, PVC film, and corrugated cardboard are hot-pressed to obtain an anti-deformation cardboard. The packaging box prepared with the anti-deformation cardboard has good waterproofness and is not easy to deform.

The invention provides a preparation method of 2-amino-5-chlorobenzhydrol, and relates to the technical field of medicine synthesis. The method comprises the following steps: dissolving 5-chloro-3-phenyl-2, 1-benzisoxazole in ethanol, reacting with sodium borohydride under the catalytic action of nitrogen-doped porous graphene-silicon dioxide until the content of 2-amino-5-chlorobenzhydrol in a reaction solution detected by HPLC (High Performance Liquid Chromatography) is not lower than 93.5%, stopping the reaction, filtering, and collecting filtrate, thereby obtaining the 2-amino-5-chlorobenzhydrol. And carrying out reduced pressure distillation on the filtrate, cooling, recrystallizing, carrying out suction filtration, and drying to obtain the 2-amino-5-chlorobenzhydrol. According to the preparation method disclosed by the invention, the 2-amino-5-chlorobenzhydrol is synthesized in one step through direct reduction by a one-pot method, synthesis and separation of an intermediate are not needed, and the reaction process is remarkably shortened.

The invention is applicable to the technical field of antibiotic intermediate preparation, and provides an efficient and environment-friendly tazobactam enzymatic preparation process, tazobactam diphenylmethyl ester is used as a substrate, high-temperature-resistant lipase is used for catalysis, water is used as a solvent, reaction is performed at 40-100 DEG C, and the conversion rate is larger than or equal to 99.5%. And filtering and recovering enzyme while hot after reaction, wherein the recovery rate is greater than or equal to 95%. The product purity is greater than or equal to 99.5%, and the benzhydrol recovery rate is greater than or equal to 90%. Compared with an existing chemical method, the process is mild in reaction condition, environment-friendly and low in cost. The embodiment verifies the feasibility of the process, the advantages of the method are prominent in proportion, the industrialization prospect is wide, and remarkable economic and social benefits can be brought.

This invention relates to the field of organic synthesis and discloses a method for preparing bifenthrin. The method includes: contacting kungfu acid and 2-methyl-3-phenylbenzyl alcohol in the presence of a catalyst composition to carry out an esterification reaction; wherein the catalyst composition includes component A and component B; wherein component A is selected from oxyacid esters of group IVB elements and / or compounds formed by group IVB elements and alcohols; wherein component B is selected from at least one of inorganic salts of copper, oxides of copper, oxides of tin, and inorganic salts of tin. The bifenthrin prepared by this method has a high yield (>98%), high purity (up to 99.4%), and produces fewer bifenthrin isomers (<0.5%), meeting market requirements. The entire process is highly efficient and environmentally friendly.

The invention provides a preparation process for co-production of methoxyamine hydrochloride and N, O-dimethyl hydroxylamine hydrochloride. Comprising the steps of aminolysis, methylation reaction, extraction separation, primary hydrolysis, distillation, dehydration and recrystallization of a first product, secondary hydrolysis, dehydration and recrystallization of a second product and the like. According to the invention, methoxyamine hydrochloride and N, O-dimethyl hydroxylamine hydrochloride can be prepared at the same time, and reaction conditions can be greatly widened, so that high-efficiency and high-yield production is realized, and meanwhile, the product purity is greatly improved; through the coproduction design, the equipment utilization rate is high, the cost is greatly reduced, the recovery rate of solution substances such as methyl acetate, dichloromethane, toluene, methanol and isopropanol is greater than or equal to 90%, the wastewater is circulated and zero discharged after being treated, only a small amount of common industrial waste salt is used as solid waste, the hazardous waste amount is greatly reduced, and the effect of environmental protection is achieved.

The application provides a cheap and simple method for regulating and controlling reduction products of photochemical reactions driven by plasmons at an interface, and belongs to the technical field of catalysis.The application can realize high selectivity and high efficiency of reduction of p-mercaptobenzoic acid (PMBA) molecules adsorbed on silver nanoparticles to generate thiophenol (TP), p-mercaptobenzaldehyde (PMBALD) or p-mercaptobenzyl alcohol (PMBALC) by adjusting excitation of localized surface plasmon resonance (LSPR) and the concentration of silver nitrate.In the method, the generation selectivity of TP, PMBALD or PMBALC is close to 100% by fine tuning the concentration of silver nitrate, and the generation selectivity of PMBALD or PMBALC is realized by regulating excitation power, excitation wavelength and excitation time of plasmon resonance (LSPR).

The invention belongs to the technical field of medicine refining and purification, and relates to a preparation method of medicinal bifonazole. The process comprises the following steps: reacting 4-phenyl benzhydrol with thionyl chloride and imidazole in a solvent toluene, adding water into the reaction liquid at high temperature, heating an organic phase, slowly adding acyl chloride, heating, stirring, cooling and crystallizing to obtain the bifonazole. The post-treatment process is simple, in the obtained product, the content of imidazole and isomer impurities and dimer impurities generated by reaction is 0.1% or below, the content of other single impurities is smaller than 0.1%, and the purity of the product is higher than 99%. The method has the advantages of low equipment requirement, low energy consumption and low production cost, and is suitable for large-scale production.

The present invention relates to a semi-aromatic polyamide material and a preparation method thereof, belonging to the technical field of materials. The semi-aromatic polyamide material is a PA6Z resin, which is insoluble in organic solvents such as formic acid, toluene, methanol, chloroform, tetrachloromethane, N,N-dimethylformamide, dimethyl sulfoxide and pyridine; the semi-aromatic polyamide material has a water absorption rate of 0.2-0.3%, a linear expansion coefficient of 10-14 ppm / °C, a melt index of 40-80 g / 10 min, an initial degradation temperature of 450-460°C, a heat deformation temperature of 200-300°C, a tensile strength of 50-60 MPa, an elongation at break of 3.3-4.5%, a flexural strength of 98-106 MPa, a flexural modulus of 2400-3600 MPa, and an impact strength of 5.8-7.6 KJ / m 2 The preparation method comprises: first, reacting 6Q monomer and terephthalic acid as raw materials to obtain PA6Q salt; then, mixing hexamethylenediamine, terephthalic acid, and PA6Q salt, and sequentially subjecting them to prepolymerization and polycondensation reactions to produce PA6Z resin. The product of the present invention combines high mechanical properties, thermal stability, low water absorption, and high dimensional stability; the preparation method is simple, safe, and reliable.

The invention discloses a preparation method of bromodiphenylmethane, and belongs to the technical field of organic synthesis.The preparation method comprises the steps that methylbenzene, hydrobromic acid and benzhydrol are mixed, then sodium bromide is added, then heating reflux reaction, standing liquid separation and refined petroleum ether treatment are conducted, cooling crystallization is conducted, and bromodiphenylmethane is obtained. The invention provides a preparation method of diphenylbromomethane, which is stable in process, safe to operate, environment-friendly and economical in cost. The method successfully solves the common problems of poor atom economy, low reaction selectivity, complicated post-treatment, difficulty in product purification and the like in the traditional bromination process by optimizing the raw material ratio and synergistic effect, accurately controlling the reaction process and adopting an original efficient purification process. The whole process from reaction to purification is optimized, and the method is particularly suitable for industrial production and has remarkable comprehensive benefits.

An aerosol generating material comprising at least two non-tobacco botanical materials, the aerosol generating material produces an aerosol when heated, the aerosol comprising: a first compound selected from the list consisting of: 2-methoxy- phenol, 2-methoxy-4-vinylphenol, vanillin, benzeneacetic acid, phenylethyl alcohol, maltol, and combinations thereof; and a second compound selected from the list consisting of: D-limonene, alpha-terpineol, levomenthol, menthol, 3-methyl butanoic acid, 2-methoxy phenol, terpinene-4-ol, 6-methyl-5-hepten-2-one, 1H-pyrrole-2- carboxaldehyde, alpha-methyl-benzenemethanol, theobromine, octadecanoic acid, n- hexadecanoic acid, methyl-ester-hexadecanoic acid, butyrolactone, caffeine, 9- octadecenoic acid, furfural, 2-methyl butanoic acid, 2,3-dihydrobenzofuran, 2- heptadecanone, and combinations thereof.

This invention discloses a method for synthesizing bifonazole, belonging to the field of pharmaceutical synthesis technology. The method uses 4-phenyldibenzyl alcohol and imidazole as raw materials, and phosphorus tribromide, phosphorus trichloride, or phosphorus oxychloride as condensing agents, to directly condense bifonazole in a solvent. The reaction conditions are mild, can be carried out at room temperature, the reaction is complete with few impurities, and the yield is high; it has low equipment requirements and is suitable for large-scale production.

The application discloses a PtZn-ZnO catalyst rich in low-potential benzene acid production x The application discloses a catalyst with a PtZn intermetallic compound structure and rich in PtZn-ZnO interface active sites, and a preparation method and application thereof. x The catalyst can significantly promote the oxidation efficiency of biomass-derived alcohol organic small molecules at a low potential (<0.9 V, relative to a reversible hydrogen electrode). x The PtZn-ZnO catalyst is applied to an electrocatalytic benzene methanol oxidation reaction, and benzene methanol can be electrocatalytically oxidized into benzene acid at a low potential of 0.725 V with a selectivity of 99.5%, and the electrocatalytic Faraday efficiency can reach 100%, and the catalyst has high conversion efficiency and excellent product selectivity.

The invention relates to degradable plastic colloidal particles and a preparation method thereof, and belongs to the technical field of degradable plastic. The colloidal particle comprises the following components in percentage by mass: 15-20 wt% of a photosensitive accelerator, 8-12 wt% of a biodegradation agent, 5-8 wt% of a plasticizer, 0.3-0.5 wt% of a compatilizer, 0.3-0.5 wt% of an antioxidant and the balance of polylactic acid. The photosensitive accelerator is prepared by the following steps: reacting 5-hydroxy-2-nitrobenzyl alcohol with di-tert-butyl dicarbonate ester to generate a phenolic hydroxyl group protection intermediate, oxidizing with chromic acid to obtain a carboxyl-terminated intermediate, reducing hydroxyl groups with trifluoroacetic acid, and polymerizing with lactide. According to the biodegradation agent, lipase and glycogen are loaded on silicon dioxide to form a compound, and then the compound is coated with a layer of compact acetalized polysaccharide film which is easy to hydrolyze and resistant to high temperature by adopting a solvent evaporation method. The plastic degradation efficiency can be effectively improved through a constructed'light triggering-biological enhancement 'bimodal synergistic degradation mechanism.

The application provides a high-temperature-resistant olefin polymerization catalyst and a preparation method thereof, and relates to the technical field of catalyst design. The high-temperature-resistant olefin polymerization catalyst is prepared by the following steps: preparing an intermediate block by reacting aniline with diphenylmethanol under the catalysis of zinc chloride, preparing a ligand compound by condensation reaction of 2-quinoline formaldehyde and the intermediate block, and finally performing coordination reaction on the mixed ligand compound after the reaction of metal chloride and Grignard reagent, and then recrystallizing to obtain the high-temperature-resistant olefin polymerization catalyst. The application overcomes the defects of the prior art, and by designing a new catalyst, the high-temperature-resistant olefin polymerization catalyst can obtain polymer products with high molecular weight at a high temperature of 160-200 DEG C, while maintaining the same order of magnitude of catalytic activity and similar comonomer insertion capacity as the CGC catalyst.

The invention relates to a preparation method of a diphenhydramine hydrochloride impurity A. The invention discloses a synthesis process of 2-(diphenyloxy)-N-methylethylamine hydrochloride, which comprises the following steps: (1) under the catalytic action of a phase transfer catalyst, carrying out chlorination reaction on benzhydrol and hydrochloric acid to obtain a compound IV; (2) carrying out selective substitution reaction on the compound IV and 2-methylethanolamine to obtain a mixture of a compound II and a compound III, and carrying out column chromatography and separation to obtain an impurity II; and (3) carrying out salt forming reaction on the compound II and a hydrogen chloride solution to generate a compound I. The raw materials of the method are simple and easy to obtain, and the product yield and purity are high.

This invention relates to catalysts, preparation methods, and applications for the one-pot catalytic oxidation of primary alcohols to esters using oxygen. The catalyst is a zinc-cobalt composite oxide, denoted as Zn-CoO, obtained by stepwise calcination of a Zn-doped modified ZIF-67 precursor. x The morphology is basically rhombic dodecahedral with a slightly concave surface, and the particle size is 0.8~1.2 μm. The primary alcohol as the reaction substrate is added to the reaction solvent, followed by the catalyst Zn-CoO. x The reaction involves the use of N-hydroxyphthalimide as a co-catalyst, with oxygen introduced into the solution during the reaction. The ester product is then separated after the reaction. This invention exhibits excellent catalytic performance for a variety of typical primary alcohols. The esterification yields are as follows: n-propanol oxidative esterification yield reaches 85.6%, n-butanol 97.0%, cyclohexylmethanol 89.9%, n-octanol 80.8%, and benzyl alcohol up to 96.0%. It demonstrates broad applicability and high selectivity for straight-chain aliphatic primary alcohols, cycloalkyl methanols, and aromatic primary alcohols.

An anti-aging modified anti-sagging resin and a preparation method therefor, and a coating. Raw materials of the modified anti-sagging resin comprise the following components in parts by weight: 60-80.5 parts of a polymer resin; 5-21 parts of a solvent; 1-3 parts of one or more mixed diisocyanates; and 1-4 parts of a primary amino-containing benzophenone. The preparation method therefor comprises: S1: mixing a primary amino diphenylmethanol with a part of a solvent to prepare a primary amino diphenylmethanol solution having a preset concentration; and S2: uniformly mixing a polymer resin and the remaining solvent in a reaction kettle and continuously stirring same, and with a temperature of the reaction system being maintained at 0-40°C, dispersing the primary amino diphenylmethanol solution prepared in step S1 into the reaction system, adding the diisocyanates and then stirring same, to obtain the modified anti-sagging resin. By using a benzophenone-based ultraviolet-light absorber existing in the form of a polyurea crystal, the volatilization risk thereof and the problem of incompatibility with a coating are avoided, and the aging resistance of the anti-sagging resin can also be enhanced.

Disclosed in the present invention are a polysilsesquioxane / polyetheretherketone composite membrane, a preparation method therefor, and a use thereof in organic mixed solvent separation. In view of the existing challenge of large-area deposition of defect-free polysilsesquioxane hybrid membranes on polymer substrates, provided is a novel membrane preparation method using a 1,2-bis(triethoxysilyl)ethane polysilsesquioxane precursor as a raw material for preparing a membrane material. From the perspectives of the simplicity of a membrane preparation process, the industrialization of a membrane separation technology, and the improvement of membrane preparation efficiency, a processing process is designed and optimized, thereby improving the membrane preparation efficiency while maintaining certain separation performance, and exhibiting excellent effects in the separation and recovery of methanol / toluene and methanol / dimethyl carbonate.

The application relates to the field of catalysts, and discloses a hydrogenation catalyst, a preparation method and application thereof, and a method for preparing alpha-methylbenzyl alcohol, the hydrogenation catalyst comprising a hydrogenation active component and a SiO2 carrier; and the catalyst surface is modified by a siloxane group. The hydrogenation catalyst has the characteristics of high low-temperature hydrogenation activity and long service life. The hydrogenation catalyst is used in a liquid-phase hydrogenation reaction, the hydrogenation catalyst has high catalytic activity, the low-temperature liquid-phase reaction can be better carried out, for example, in the preparation of alpha-methylbenzyl alcohol, the raw material acetophenone can have high conversion rate, the alpha-methylbenzyl alcohol has high selectivity, and the hydrogenation catalyst has long service life.

The invention discloses a damping and buffering polyurethane insole material and a preparation method thereof, and belongs to the field of polyurethane materials. According to the preparation method, a component A, a component B and a component C are prepared respectively, the component A comprises polyethylene glycol adipate, simethicone and the like, the component B comprises polyethylene glycol adipate, polyoxypropylene glycol and the like, the component C is formed by mixing dimethyl thio-toluenediamine, a functional cross-linking agent and the like, and the functional cross-linking agent is formed by mixing 3, 4, 6-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3 The preparation method comprises the following steps: introducing a hindered phenol group and a dynamic disulfide bond into the raw materials such as 1, 5-di-tert-butyl-4-hydroxybenzyl alcohol; and mixing the three components, performing injection molding, curing and demolding to obtain a finished product. Multiple weak interaction and reversible dynamic covalent bonds are constructed through the functional cross-linking agent, the damping and buffering performance, the rebound resilience and the compression fatigue resistance of the material are synergistically improved in combination with soft and hard segment proportion regulation, and the technical problems that the buffering performance and the rebound resilience of a traditional polyurethane insole are difficult to consider at the same time, and permanent deformation is likely to be generated are effectively solved.