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A kind of preparation method of reversible thermosensitive hydrogel ink

A temperature-sensitive hydrogel and ink technology, which is applied in the field of preparation of reversible temperature-sensitive hydrogel ink, can solve problems such as poor structural stability of hydrogel ink, and achieve the effect of improving structural stability.

Active Publication Date: 2021-08-06
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of reversible temperature-sensitive hydrogel ink, which solves the problem of poor structural stability of existing hydrogel inks

Method used

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  • A kind of preparation method of reversible thermosensitive hydrogel ink

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preparation example Construction

[0026] A kind of preparation method of reversible thermosensitive hydrogel ink of the present invention, specifically implement according to the following steps:

[0027] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0028] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C to 4°C, add triethylamine, and pass through nitrogen for 15 to 20 minutes to obtain a mixture a;

[0029] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:10~20;

[0030] Step 1.2: Add acryloyl chloride dropwise to the mixed liquid a obtained after step 1.1 at a rate of 1 to 2 drops per second, and then place it in an ice-water bath at 0°C to 4°C for 48h to 60h to obtain a reaction mixture , and then filter the reaction mixture, remove the filter residue, and obtain the reaction solution;

[0031] The mass ratio...

Embodiment 1

[0044] A kind of its preparation method of reversible thermosensitive hydrogel ink, specifically implement according to the following steps:

[0045] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0046] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C, add triethylamine, and pass through nitrogen for 15 minutes to obtain a mixture a;

[0047] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:10;

[0048] Step 1.2: Add acryloyl chloride dropwise to the mixture a obtained after step 1.1 at a rate of 1 drop per second, and then place it in an ice-water bath at 0°C for 48 hours to obtain a reaction mixture, and then filter the reaction mixture , remove filter residue, obtain reaction solution;

[0049] The mass ratio of acryloyl chloride to mixed liquid a is 1:10;

[0050] Step 1.3, ...

Embodiment 2

[0061] A kind of its preparation method of reversible thermosensitive hydrogel ink, specifically implement according to the following steps:

[0062] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0063] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C, add triethylamine, and pass through nitrogen for 18 minutes to obtain a mixture a;

[0064] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:15;

[0065] Step 1.2: Add acryloyl chloride dropwise to the mixture a obtained after step 1.1 at a rate of 1 drop per second, and then place it in an ice-water bath at 2°C for 50 hours to obtain a reaction mixture, and then filter the reaction mixture , remove filter residue, obtain reaction solution;

[0066] The mass ratio of acryloyl chloride to mixed liquid a is 1:12;

[0067] Step 1.3, ...

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Abstract

The invention discloses a preparation method of a reversible temperature-sensitive hydrogel ink, specifically: firstly, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127; using free radicals to initiate polymerization and crosslinking Acrylylate F127; then dissolve it in water, add micellizable polysaccharide at 1°C to 5°C, stir evenly, and heat up to obtain reversible thermosensitive hydrogel ink. In this method, chemically cross-linked F127 micelles are formed by pre-crosslinking acrylylated F127, and after mixing with micellizable polysaccharides, reversible thermosensitive hydrogels can be obtained, which improves the structure of hydrogel inks. Stability, its sol-gel transition temperature is adjustable between 28 and 40 degrees.

Description

technical field [0001] The invention belongs to the technical field of hydrogel ink material preparation, and in particular relates to a preparation method of reversible temperature-sensitive hydrogel ink. Background technique [0002] The "hydrogel" scaffold is similar to the structure of the extracellular matrix of the organism, and can provide a good environment for cells to obtain nutrition, growth and metabolism during the tissue healing process. It has the function of promoting healthy tissue growth and accelerating wound healing, so it has become an ideal Injectable or 3D printable bioinks. Since both in vivo physiological temperature and in vitro cell culture are in a nutrient solution environment at a temperature of 37 °C, thermosensitive hydrogel inks with the lowest critical transition temperature are an easy way to achieve injectable / 3D bioprinting. At present, reversible thermosensitive hydrogels with biocompatibility mainly include: block copolymers such as Pl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L33/00C08L5/08C08L1/28
CPCC08J3/075C08J2305/08C08J2333/00C08J2401/28C08J2405/08C08J2433/00
Inventor 任鹏刚张华
Owner XIAN UNIV OF TECH
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