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A preparation method of dual-response hydrogel ink

A hydrogel, dual-response technology, applied in the field of preparation of dual-response hydrogel ink, can solve the problems of poor reversible temperature response and low stability

Active Publication Date: 2021-06-15
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing a dual-response hydrogel ink, which solves the problems of low structural stability and poor reversible temperature response of the existing hydrogel ink

Method used

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  • A preparation method of dual-response hydrogel ink

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preparation example Construction

[0030] A method for preparing a double-response hydrogel ink of the present invention is specifically implemented according to the following steps:

[0031] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0032] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C to 4°C, add triethylamine, and pass through nitrogen for 15 to 20 minutes to obtain a mixture a;

[0033] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:10~20;

[0034] Step 1.2: Add acryloyl chloride dropwise to the mixed liquid a obtained after step 1.1 at a rate of 1 to 2 drops per second, and then place it in an ice-water bath at 0°C to 4°C for 48h to 60h to obtain a reaction mixture , and then filter the reaction mixture, remove the filter residue, and obtain the reaction solution;

[0035] The mass ratio of acryloyl c...

Embodiment 1

[0054] A method for preparing a double-response hydrogel ink of the present invention is specifically implemented according to the following steps:

[0055] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0056] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C, add triethylamine, and pass through nitrogen for 15 minutes to obtain a mixture a;

[0057] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:10;

[0058] Step 1.2: Add acryloyl chloride dropwise to the mixture a obtained after step 1.1 at a rate of 1 drop per second, and then place it in an ice-water bath at 0°C for 48 hours to obtain a reaction mixture, and then filter the reaction mixture , remove filter residue, obtain reaction solution;

[0059] The mass ratio of acryloyl chloride to mixed liquid a is 1:10;

[0060] Ste...

Embodiment 2

[0077] A method for preparing a double-response hydrogel ink of the present invention is specifically implemented according to the following steps:

[0078] Step 1, using the nucleophilic addition reaction of acryloyl chloride and the hydroxyl group of Pluronic F127 to prepare acryloyl F127 (F127DA), specifically:

[0079] Step 1.1: Dissolve Pluronic F127 in anhydrous dichloromethane, place in an ice-water bath at 0°C, add triethylamine, and pass through nitrogen for 18 minutes to obtain a mixture a;

[0080] The molar ratio of Pluronic F127, anhydrous dichloromethane and triethylamine is 1:5:15;

[0081] Step 1.2: Add acryloyl chloride dropwise to the mixture a obtained after step 1.1 at a rate of 1 drop per second, and then place it in an ice-water bath at 2°C for 50 hours to obtain a reaction mixture, and then filter the reaction mixture , remove filter residue, obtain reaction solution;

[0082] The mass ratio of acryloyl chloride to mixed liquid a is 1:12;

[0083] Ste...

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Abstract

The invention discloses a preparation method of a dual-response hydrogel ink, specifically: firstly, preparing acrylylated F127, using free radicals to initiate polymerization to crosslink the acrylylated F127, and then preparing a methacrylylated quaternary ammonium salt shell polysaccharide solution, then dissolve the cross-linked acryloyl F127 in water, add the methacryloyl quaternary ammonium chitosan solution, stir evenly, add the photoinitiator, heat up, and finally use 5-10W 405nm light to trigger cross-linking The dual-response hydrogel ink can be obtained by linking the prepared hydrogel. In this method, chemically cross-linked F127 micelles are formed by pre-cross-linking acrylylated F127, and after assembly with micellizable methacrylylated quaternary ammonium chitosan, reversible thermosensitive hydrogels can be obtained. Gel, whose sol-gel transition temperature is adjustable between 28 and 40 degrees, and the mechanical strength of the gel can be adjusted through light response, so as to meet the microenvironmental mechanical requirements for tissue repair such as skin and cartilage.

Description

technical field [0001] The invention belongs to the technical field of preparation of hydrogel ink materials, and in particular relates to a preparation method of double-response hydrogel ink. Background technique [0002] The "hydrogel" scaffold is similar to the structure of the extracellular matrix of the organism, and can provide a good environment for cells to obtain nutrition, growth and metabolism during the tissue healing process. It has the function of promoting healthy tissue growth and accelerating wound healing, so it has become an ideal Injectable or 3D printable bioinks. Since both in vivo physiological temperature and in vitro cell culture are in a nutrient solution environment at a temperature of 37 °C, thermosensitive hydrogel inks with the lowest critical transition temperature are an easy way to achieve injectable / 3D bioprinting. At present, reversible thermosensitive hydrogels with biocompatibility mainly include: block copolymers such as Pluronic F127 a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L33/00C08L5/08
CPCC08J3/075C08J3/24C08J2333/00C08J2405/08
Inventor 任鹏刚张华
Owner XIAN UNIV OF TECH
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