Medicinal injectable anti-adhesive gel and preparation method thereof

Abstract

The invention relates to a medicinal injectable anti-adhesive gel and a preparation method thereof. The gel is prepared from a crosslinking agent and natural polymer or synthesized polymer in a mass ratio of (0.01-1):1. The preparation method comprises the following steps: respectively preparing phosphate buffer solutions of macromolecular polymer and crosslinking agent; filling two injection syringes of a two-way injection device; extruding the two-way injection device to mix the two solutions in a needle and form gel; and injecting the natural or synthesized polymer solution with an anti-adhesive effect and the crosslinking agent to the wound position by virtue of the two-way injection device, quickly filling gaps around nerves or tendons and other tissues, and in-situ forming flexible gel in a short time. The gel is not influenced by positions, can endure stress of peripheral tissues and does not have pressure effect. Since the gel is crosslinked by the crosslinking agent, the gel has a relatively long degradation time, is capable of completely preventing the operating wound from adhering in the chronic inflammation period, and can be finally degraded or absorbed in the body. The medicinal injectable anti-adhesive gel can be widely applied.

Description

technical field [0001] The invention relates to a medical injectable anti-adhesion gel and a preparation method thereof. The medical injectable anti-adhesion gel combines the advantages of anti-adhesion film and anti-adhesion liquid. The natural or synthetic polymer solution and chemical cross-linking agent with anti-adhesion effect are injected into the wound site through a double injection device. The initial state A flowable liquid that quickly fills the gaps around tissues such as nerves or tendons, and forms a soft gel in situ in a short period of time. The gel is not affected by the position of the body, can bear the pressure of the surrounding tissue and has no compressive effect itself. In addition, since the gel is cross-linked by a cross-linking agent, its degradation time is longer, which can completely prevent the adhesion of the surgical wound during the chronic inflammation period, and finally be degraded or absorbed in the body. The anti-adhesion gel in the pr...

AI Technical Summary

Problems solved by technology

Although the current anti-adhesion film material has a long degradation time, its automatic adhesion is poor, and it cannot be fully attached to the wound surface. It needs to be sutured to ensure its use effect, and the expected anti-adhesion effect cannot be achieved; while the anti-adhesion liquid The degradation time of the wound is relatively short, usually the material is completely absorbed by the body after the acute inflammatory period of the wound, and cannot prevent the adhesion of the wound during the chronic inflammatory period, so the expected anti-adhesion effect cannot be achieved

[0006] In summary, the anti-adhesion film and anti-adhesion liquid have poor anti-adhesion effects on nerves, surrounding tissues, tendons and other parts

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