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Medicinal injectable anti-adhesive gel and preparation method thereof

An anti-adhesion and gel technology, which is applied in the fields of medical science and surgery, can solve the problems of poor anti-adhesion effect, poor automatic adhesion, and inability to stick wounds, etc., and achieve good biocompatibility and short gelation time , the effect of simple operation

Active Publication Date: 2015-01-28
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the current anti-adhesion film material has a long degradation time, its automatic adhesion is poor, and it cannot be fully attached to the wound surface. It needs to be sutured to ensure its use effect, and the expected anti-adhesion effect cannot be achieved; while the anti-adhesion liquid The degradation time of the wound is relatively short, usually the material is completely absorbed by the body after the acute inflammatory period of the wound, and cannot prevent the adhesion of the wound during the chronic inflammatory period, so the expected anti-adhesion effect cannot be achieved
[0006] In summary, the anti-adhesion film and anti-adhesion liquid have poor anti-adhesion effects on nerves, surrounding tissues, tendons and other parts

Method used

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  • Medicinal injectable anti-adhesive gel and preparation method thereof
  • Medicinal injectable anti-adhesive gel and preparation method thereof
  • Medicinal injectable anti-adhesive gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of chitosan-sodium glycerophosphate-glutaraldehyde double network rapid response gel (refer to Chinese patent CN103937014A)

[0043] Weigh 2.5 g of chitosan powder (deacetylation degree 98%, molecular weight 100 kDa), dissolve it in 50 mL of 0.1 mol / L hydrochloric acid solution, and obtain a chitosan solution with a mass fraction of 5%. Take out 9mL of this solution, and add 1mL of sodium glycerophosphate solution with a mass fraction of 50% (in which β-sodium glycerophosphate accounts for 90% of the solid powder of sodium glycerophosphate) dropwise in an ice-water bath at 0°C. After the addition is complete, at this time The pH value of the solution is about 7.2, and the solution is stored at 4°C, and this solution is used as solution A. Weigh 0.02g of glutaraldehyde (mass ratio to chitosan in solution A is 0.04:1) and dissolve in 10mL of water for injection, and this solution is used as solution B.

[0044] Put part of liquid A and liquid B int...

Embodiment 2

[0045] Example 2: Preparation of oxidized carboxymethylcellulose and lanine injectable gel

[0046] Weigh 5.0 g of oxidized carboxymethyl cellulose powder (degree of oxidation 20%, molecular weight 100 kDa), dissolve it in 50 mL of PBS buffer solution with pH=7.2, obtain a 10% oxidized carboxymethyl cellulose solution, and take out 2mL was used as liquid A. Weigh 0.02g of lysine (the mass ratio of oxidized carboxymethyl cellulose in solution A is 0.1:1) and dissolve it in 2mL of PBS buffer solution with pH=7.2, and this solution is used as solution B.

[0047] Put liquid A and liquid B into tube A and tube B correspondingly, wherein the liquid volume of tube A and tube B are both 2mL, and the length of tube A and tube B is the same. Then install the AB tube on the sterile double injection device, and at the same time push out the A liquid and the B liquid to mix, the injection time is 10s, after pushing out the mixed liquid, refer to the method of Chinese patent CN103937014A ...

Embodiment 3

[0048] Example 3: Preparation of PEG-NHS active ester and trilysine injectable gel

[0049] Weigh 2.0 g of eight-arm PEG-NHS active ester (NHS substitution degree 95%, single arm molecular weight 10kDa), dissolve it in 50 mL of PBS buffer solution with pH=3.0, and obtain eight-arm PEG-NHS active ester with a mass fraction of 4%. , take out 2mL from it as solution A. Weigh 0.01g of trilysine (the mass ratio of eight-arm PEG-NHS active ester in solution A is 0.125:1) and dissolve it in 2mL of PBS buffer solution with pH=11.2, and this solution is used as solution B.

[0050]Put liquid A and liquid B into tube A and tube B correspondingly, wherein the liquid volume of tube A and tube B are both 2mL, and the length of tube A and tube B is the same. Then install the AB tube on the sterile double injection device, and at the same time push out the A liquid and the B liquid to mix, the injection time is 10s, after pushing out the mixed liquid, refer to the method of Chinese patent C...

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Abstract

The invention relates to a medicinal injectable anti-adhesive gel and a preparation method thereof. The gel is prepared from a crosslinking agent and natural polymer or synthesized polymer in a mass ratio of (0.01-1):1. The preparation method comprises the following steps: respectively preparing phosphate buffer solutions of macromolecular polymer and crosslinking agent; filling two injection syringes of a two-way injection device; extruding the two-way injection device to mix the two solutions in a needle and form gel; and injecting the natural or synthesized polymer solution with an anti-adhesive effect and the crosslinking agent to the wound position by virtue of the two-way injection device, quickly filling gaps around nerves or tendons and other tissues, and in-situ forming flexible gel in a short time. The gel is not influenced by positions, can endure stress of peripheral tissues and does not have pressure effect. Since the gel is crosslinked by the crosslinking agent, the gel has a relatively long degradation time, is capable of completely preventing the operating wound from adhering in the chronic inflammation period, and can be finally degraded or absorbed in the body. The medicinal injectable anti-adhesive gel can be widely applied.

Description

technical field [0001] The invention relates to a medical injectable anti-adhesion gel and a preparation method thereof. The medical injectable anti-adhesion gel combines the advantages of anti-adhesion film and anti-adhesion liquid. The natural or synthetic polymer solution and chemical cross-linking agent with anti-adhesion effect are injected into the wound site through a double injection device. The initial state A flowable liquid that quickly fills the gaps around tissues such as nerves or tendons, and forms a soft gel in situ in a short period of time. The gel is not affected by the position of the body, can bear the pressure of the surrounding tissue and has no compressive effect itself. In addition, since the gel is cross-linked by a cross-linking agent, its degradation time is longer, which can completely prevent the adhesion of the surgical wound during the chronic inflammation period, and finally be degraded or absorbed in the body. The anti-adhesion gel in the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14C08J3/24C08J3/075
Inventor 简军李睿智李东风
Owner IMEIK TECH DEV CO LTD
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