Medical hydrogel

A hydrogel and medical technology, applied in the field of biomedicine, can solve the problems of wide molecular weight distribution, low long-term stability and unfavorable discharge of hyperbranched polymers, and achieve good application value, good stability and short gelation time Effect

Active Publication Date: 2019-06-28
SHANGHAI RUINING BIOTECH CO LTD
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The aldehyde groups in the aldehyde group-terminated hyperbranched polymer HP-PEG-CHO are linked to the polymer through ester bonds, and the long-term stability in aqueous solution is low. In addition, the molecular weight distribution of the hyperbranched polymer is wide and may contain higher molecular weight Polymers that are not conducive to human excretion

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Dissolve 600mg of 8-arm polyethylene glycol 8-PEG-O-BA (M.W.10K) linked by ether linkage to phenylaldehyde group in 2mL of phosphate buffer (pH7.4) as solution A; prepare polyethylene The phosphate buffer saline solution of imine 2.2% (w / v) is used as B solution; A, B solution equal volumes are mixed to obtain viscous hydrogel, the gelation time is 21 seconds, and the gel bursting strength is 16kPa.

Embodiment 2

[0036] Dissolve 600 mg of ether-linked benzaldehyde-terminated 8-arm polyethylene glycol 8-PEG-O-BA (M.W.13.5K) in 2 mL of phosphate buffer (pH 7.4) as solution A; Ethyleneimine 1.67% (w / v) phosphate buffer solution is used as solution B; equal volumes of solutions A and B are mixed to obtain a viscous hydrogel, the gelling time is 22 seconds, and the bursting strength of the gel is 22 seconds. is 11kPa.

Embodiment 3

[0038] Dissolve 400 mg of amide bond-linked benzaldehyde-terminated 8-arm polyethylene glycol 8-PEG-amide-BA (M.W.10K) in 2 mL of phosphate buffer (pH 7.4) as solution A; Amine 1.48% (w / v) phosphate buffer solution, as B solution; mix A and B solutions in equal volumes to obtain a viscous hydrogel, the gelling time is 2 seconds, and the gel bursting strength is 13kPa .

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Abstract

The invention discloses medical hydrogel. The medical hydrogel is formed by formyl-terminated star multi-arm polyethylene glycol and a polyamino compound through in-situ crosslinking, and formyl and star multi-arm polyethylene glycol are connected through chemical bonds such as ether bonds or amido bonds or felbamate bonds or imine bonds or urea bonds. According to the medical hydrogel, formyl groups at the end of multi-arm polyethylene glycol and amidogen groups of the polyamino compound react to generate Schiff alkali, and therefore cross-linking is generated, and the medical injectable gelis formed. The prepared hydrogel is short in gelling time, has ideal gel bursting strength, and is good in stability in a water solution, and compared with existing medical gel, higher application value is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a medical hydrogel, which can be used in the fields of postoperative tissue sealing and anti-leakage, anti-tissue adhesion, tissue filler, tissue repair, skin dressing, drug release and the like. Background technique [0002] Hydrogel is a kind of soft material containing a large amount of water obtained by cross-linking hydrophilic polymers. Hydrogels have excellent physical and chemical properties and biological properties, such as high water content, high elasticity, softness, and biocompatibility, and have important application values ​​in biomedical research fields such as drug delivery and tissue engineering. Injectable hydrogel refers to a type of hydrogel that has certain fluidity and can be applied by injection. It shows a phase transition between sol and gel in response to external stimuli (temperature, temperature / pH changes, etc.). It is liquid or semi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/08A61K47/10A61K47/18A61K47/34A61K47/32A61L24/00A61L24/04A61L27/26A61L27/52A61L31/04A61L31/06A61L31/14
CPCA61K9/06A61K47/34A61L24/0031A61L24/043A61L31/041A61L31/145A61L2430/40C08G12/46C08G65/331C08G2650/30C08L71/02C08L79/08A61K47/10C08L77/04C08L79/02
Inventor 潘震陈亮侯森
Owner SHANGHAI RUINING BIOTECH CO LTD
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