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Multifunctional controlled-release anti-inflammatory analgesic paste and preparation method and application thereof

An anti-inflammatory and analgesic, multi-functional technology, applied in the direction of anti-inflammatory agents, pharmaceutical formulations, and other medical devices, can solve the problems of limiting drug efficacy and uncontrollability, so as to relieve pain, promote release, and avoid gastrointestinal The effect of the reaction

Active Publication Date: 2017-08-18
广东云曌医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even when applied externally, due to the uncontrollability of use, there is a contradiction between the exact curative effect and adverse reactions of this kind of drug, which limits the exertion of the curative effect of the drug

Method used

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  • Multifunctional controlled-release anti-inflammatory analgesic paste and preparation method and application thereof
  • Multifunctional controlled-release anti-inflammatory analgesic paste and preparation method and application thereof
  • Multifunctional controlled-release anti-inflammatory analgesic paste and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] 1. Nano-TiO loaded with gold and magnetic 2 Particles (Au / Fe 3 o 4 / TiO 2 ) preparation

[0075] (1) Add 1g FeCl 2 , 1g FeCl 3 Dissolved in HCl solution, under N 2 Under the environment, gradually add 50mL NaOH solution dropwise to the reaction solution until black precipitates are formed, and keep stirring at a high speed of 500rpm. After the reaction is matured, the precipitate is separated with a magnet, washed with deionized water, and dispersed in an aqueous solution again. Then, 0.1 mol / L citric acid was added dropwise to adjust the pH of the solution to 6.0 to obtain a water-based magnetic fluid. Finally, filter the water-based magnetic fluid with distilled water, and dry the filter cake to obtain Fe 3 o 4 magnetic nanoparticles.

[0076] (2) The above obtained Fe 3 o 4 0.1 g of magnetic nanoparticles was dispersed in water, and 0.1 mL of concentrated ammonia water and 0.1 mL of titanium source were added in turn at room temperature and under rapid st...

Embodiment 2

[0086] 1. Nano-TiO loaded with gold and magnetic 2 Granule preparation

[0087] (1) Add 10gFeCl 2 , 10gFeCl 3 Dissolved in HCl solution, under N 2 Under the environment, gradually drop 200mL NaOH solution into the reaction solution until black precipitates are formed, and maintain high-speed stirring at 10000rpm. After the reaction is matured, the precipitate is separated with a magnet, washed with deionized water, and dispersed in an aqueous solution again. Then, 0.1 mol / L citric acid was added dropwise to adjust the pH of the solution to 6.0 to obtain a water-based magnetic fluid. Finally, filter the water-based magnetic fluid with distilled water, and dry the filter cake to obtain Fe 3 o 4 magnetic nanoparticles.

[0088] (2) The above obtained Fe 3 o 4 2 g of magnetic nanoparticles were dispersed in water, and 2 mL of concentrated ammonia water and 10 mL of titanium source were sequentially added at room temperature under rapid stirring by an emulsifying shearer a...

Embodiment 3

[0098] 1. Nano-TiO loaded with gold and magnetic 2 Granule preparation

[0099] (1) Add 4.0g FeCl 2 , 5.4gFeCl 3 Dissolved in HCl solution, under N 2 Under the environment, gradually add 180mL NaOH solution dropwise to the reaction solution until black precipitates are formed, and maintain high-speed stirring at 8000rpm. After the reaction is matured, the precipitate is separated with a magnet, washed with deionized water, and dispersed in an aqueous solution again. Then, 0.1 mol / L citric acid was added dropwise to adjust the pH of the solution to 6.0 to obtain a water-based magnetic fluid. Finally, filter the water-based magnetic fluid with distilled water, and dry the filter cake to obtain Fe 3 o 4 magnetic nanoparticles.

[0100] (2) The above obtained Fe 3 o 4 1 g of magnetic nanoparticles was dispersed in water, and 1 mL of concentrated ammonia water and 5 mL of titanium source were sequentially added at room temperature under rapid stirring by an emulsifying she...

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Abstract

The invention discloses a multifunctional controlled-release anti-inflammatory analgesic paste and preparation method and application thereof. The multifunctional controlled-release anti-inflammatory analgesic paste comprises an adhesive layer and a medicine layer; by use of the electrospinning technology, the macromolecule polymer or the natural high-molecular fiber protein is uniformly mixed with the gold-loaded and magnet-loaded nanometer TiO2 particles, the dispersing agent, the penetration enhancer and the anti-inflammatory analgesic medicine to obtain a mixture, the mixture is placed under the high-voltage electrostatic field to perform spinning so as to obtain the dual-layer nanometer composite film, and then the adhesive is sprayed on the dual-layer nanometer composite film to obtain the multifunctional controlled-release anti-inflammatory analgesic paste. The analgesic paste is used for external application, and capable of effectively avoiding liver first pass effect and the damage on the gastrointestinal mucous membrane by non-steroidal anti-inflammatory drugs (NSAIDs) and other bad effects, and the aims of controlling the release of the medicine by use of an external magnetic field and the near infrared, improving the curative effect of the medicine, and the aim of accelerating the removing of pains in cooperation with the treatment of the infrared therapy lamp can be finally achieved; the multifunctional controlled-release anti-inflammatory analgesic paste has relatively good curative effect on the muscle pains, various arthritis and non-rheumatic inflammation.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a multifunctional controlled-release anti-inflammatory and analgesic patch as well as its preparation method and application. Background technique [0002] Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of commonly used antipyretic and analgesic drugs, including salicylic acid, aniline, pyrazolone, indole acetic acid, anthranilic acid and aryl alkanoic acid . In addition to anilines, NSAIDs can inhibit cyclooxygenase (COX) in the metabolism of arachidonic acid, reduce the synthesis of prostaglandins (PGs), and thus achieve antipyretic, analgesic and anti-inflammatory effects. [0003] NSAIDs are suitable for pain caused by tissue damage or inflammation, such as joint pain, muscle pain, headache, dysmenorrhea, and cancer pain. Long-term use does not cause euphoria and addiction, and most drugs have good anti-inflammatory effects. Some drugs, such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/00A61K47/22A61K47/42A61K47/32A61K47/34A61P29/00A61P19/02A61P21/00A61P11/00A61P17/02A61P25/00A61M37/00
CPCA61K9/7023A61K45/00A61K47/22A61K47/32A61K47/34A61K47/42A61M37/00A61M2037/0007
Inventor 周武艺麦卓贤董先明黄梦文王晓君黄永欣
Owner 广东云曌医疗科技有限公司
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