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Aspirin slow release tablet and preparation method thereof

A technology of aspirin and sustained-release tablets, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve waste, affect the clinical use of drugs, and the release rate of sustained-release tablets is unstable, etc. question

Inactive Publication Date: 2013-06-12
郑州市协和制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the release rate of the sustained-release tablet is unstable, and there are large differences between different batches of tablets, resulting in difficulties in quality control and directly affecting the clinical use of the drug.
In view of this, because there are often unqualified batches of products, it causes great waste, which leads to a great increase in the production cost of the product

Method used

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  • Aspirin slow release tablet and preparation method thereof
  • Aspirin slow release tablet and preparation method thereof
  • Aspirin slow release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Prepare 3% hypromellose alcohol solution:

[0048] (1), 3% hypromellose alcohol solution prescription

[0049] Tartaric acid 2.5kg water 10.00kg polysorbate 801.0kg

[0050] Hypromellose 1.5kg 95% Ethanol 32.0kg

[0051] (2), take tartaric acid, water, polysorbate 80, hypromellose, 95% ethanol. Dissolve tartaric acid in water, heat to 70°C and stir to dissolve completely, then add polysorbate 80, stir to dissolve completely; add hypromellose while stirring to make it evenly dispersed in 95% ethanol ; Pour the above two solutions together and mix evenly, and place at 18-26°C for 8 hours to 72 hours.

[0052] The above tartaric acid, water, polysorbate 80, hypromellose, and 95% ethanol should meet the requirements of "The Pharmacopoeia of the People's Republic of China 2010 Edition Part Two", and require that the fineness of hypromellose can all pass through an 80-mesh sieve , viscosity 55mPa·s,

[0053] (2) Granulation

[0054] (1), prescription

[0055] Aspir...

Embodiment 2

[0062] (1) Prepare 3% hypromellose alcohol solution:

[0063] (1), 3% hypromellose alcohol solution prescription

[0064] Tartaric acid 2.25kg water 6.00kg polysorbate 800.6kg

[0065] Hypromellose 0.9kg 95% Ethanol 19.2kg

[0066] (2), take tartaric acid, water, polysorbate 80, hypromellose, 95% ethanol. Dissolve tartaric acid in water, heat to 70°C and stir to dissolve completely, then add polysorbate 80, stir to dissolve completely; add hypromellose while stirring to make it evenly dispersed in 95% ethanol ; Pour the above two solutions together and mix evenly, and place at 18-26°C for 8 hours to 72 hours.

[0067] The above tartaric acid, water, polysorbate 80, hypromellose, and 95% ethanol should meet the requirements of "The Pharmacopoeia of the People's Republic of China 2010 Edition Part Two", and require that the fineness of hypromellose can all pass through an 80-mesh sieve , viscosity 55mPa·s,

[0068] (2) Granulation

[0069] (1), prescription

[0070] Aspir...

Embodiment 3

[0077] (1) Prepare 3% hypromellose alcohol solution:

[0078] (1), 3% hypromellose alcohol solution prescription

[0079] Tartaric acid 2.25kg water 6.00kg polysorbate 800.6kg

[0080] Hypromellose 0.9kg 95% Ethanol 19.2kg

[0081] (2), take tartaric acid, water, polysorbate 80, hypromellose, 95% ethanol. Dissolve tartaric acid in water, heat to 70°C and stir to dissolve completely, then add polysorbate 80, stir to dissolve completely; add hypromellose while stirring to make it evenly dispersed in 95% ethanol ; Pour the above two solutions together and mix evenly, and place at 18-26°C for 8 hours to 72 hours.

[0082] The above tartaric acid, water, polysorbate 80, hypromellose, and 95% ethanol should meet the requirements of "The Pharmacopoeia of the People's Republic of China 2010 Edition Part Two", and require that the fineness of hypromellose can all pass through an 80-mesh sieve , viscosity 60mPa·s,

[0083] (2) Granulation

[0084] (1), prescription

[0085] Aspir...

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Abstract

The invention discloses an aspirin slow release tablet which is prepared from the following raw materials in parts by weight: 25-100 parts of aspirin, 15-30 parts of 3% hydroxypropyl methylcellulose alcoholic liquid, 5-10 parts of polyacrylic resin, 2-8 parts of hydroxypropyl methylcellulose and 1-5 parts of talcum powder. The 3% hydroxypropyl methylcellulose alcoholic liquid is prepared from the following raw materials in parts by weight: 2-5 parts of tartaric acid, 8-15 parts of water, 0.8-1.5 parts of polysorbate, 1-3 parts of hydroxypropyl methylcellulose and 25-50 parts of 95% ethanol. Finenesses of aspirin, polyacrylic resin II and hydroxypropyl methylcellulose can pass through an 80-mesh sieve, and viscosity of hydroxypropyl methylcellulose is 55-60Pa.s. The aspirin slow release tablet prepared by the invention is better in uniformity and quality stability, and the release rate of medicine can be more effectively controlled, so that the local medical concentration is reduced, the blood concentration is more stable and sustainable, and toxic and side effects to gastrointestinal mucous membrane are greatly reduced.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations, in particular to an aspirin sustained-release tablet for treating acute ischemic stroke and cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] For more than half a century after the advent of aspirin, people have been used as an antipyretic and analgesic for the treatment of fever, headache, neuralgia, muscle pain, toothache, dysmenorrhea, acute rheumatoid arthritis, and rheumatoid arthritis. In recent years, it is often used clinically to prevent and treat acute ischemic stroke and cardiovascular and cerebrovascular diseases. The main problem of clinically used aspirin preparations is that they are highly irritating to the gastrointestinal tract, and may even cause the risk of gastric hemorrhage or cerebral hemorrhage. It disintegrates in time and is directly excreted from the body. Even if it disintegrates, it will produce a h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/616A61K47/38A61K47/32A61P9/10A61P9/00
Inventor 李建中
Owner 郑州市协和制药厂
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