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Poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA)-isoplyacid nano compound antitumor medicament and preparation method thereof

An anti-tumor drug and nano-composite technology, which is applied in the field of drug synthesis, can solve the problems of limited use of tumor chemotherapy drugs, large toxic and side effects, and low treatment efficiency, and achieve a clean, pollution-free process, economical process, and strong operability Effect

Inactive Publication Date: 2011-07-06
BEIJING UNIV OF CHEM TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although it has a certain curative effect on most tumors, it has problems such as low treatment efficiency, poor selectivity, large toxic and side effects, and drug resistance of cancer cells for some tumor types, such as liver cancer, prostate cancer, melanoma, and cervical cancer.
Due to severe toxic and side effects, the use of tumor chemotherapy drugs is greatly restricted

Method used

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  • Poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA)-isoplyacid nano compound antitumor medicament and preparation method thereof
  • Poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA)-isoplyacid nano compound antitumor medicament and preparation method thereof
  • Poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA)-isoplyacid nano compound antitumor medicament and preparation method thereof

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Experimental program
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Embodiment 1

[0023] 1. Prepare a high molecular polymer PGEA solution, weigh 48.4mg of PGEA and dissolve it in 10ml of ultrapure water to obtain a PGEA aqueous solution with a monomer concentration of 0.02mol / L; the structure of PGEA is shown in the following formula, 40≤m≤90 ;

[0024]

[0025] 2. Preparation of isopoly acid solution: take 24.5 mg of [NH 3 CH(CH 3 ) 2 ] 6 [Mo 7 o 24 ]·3H 2 O solid powder, be dissolved in the ultrapure water of 10ml, obtain the isopolyacid solution of 0.01mol / L, vibrate with oscillator, mix for subsequent use; Then this isopolyacid solution is diluted to 0.004mol / L;

[0026] 3. Pour the isopolyacid solution into the polymer PGEA solution and mix to form a colloidal solution. The ratio of PGEA monomer concentration to isopolyacid concentration is 5:1. Shake evenly and leave it for 2 hours to obtain PGEA-isopolyacid nano Compound antineoplastic drugs.

[0027] The prepared PGEA-homopolyacid nanocomposite antineoplastic drug is stabilized and evenl...

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Abstract

The invention discloses a nano antitumor medicament prepared by compounding water-soluble polymer poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA) with isoplyacid having antitumor performance and a preparation method thereof. The method comprises the following steps of: preparing isoplyacid aqueous solution and macromoleclar polymer aqueous solution with certain concentration; and uniformly mixing the two kinds of solution to obtain the macromoleclar polymer-isoplyacid nano compound antitumor medicament. By the nano antitumor medicament, the ordered assembly of the polymer PGEA serving as a medicinal carrier with a bioactivity function and isoplyacid anions with antitumor medicinal value is realized for the first time, and the compound medicament has a nano order of magnitude. The compound medicament has a simple preparation process, high maneuverability and an economic, clean and pollution-free process.

Description

technical field [0001] The invention belongs to the technical field of drug synthesis, and in particular relates to a nano anti-tumor drug compounded by a water-soluble polymer PGEA and an isopolyacid with anti-tumor properties and a preparation method thereof. Background technique [0002] Polyacid compounds are a class of multimetal oxides containing V, Mo, W and other metals. Isopolyanions formed by the condensation of the same oxoacid ions are called isopolyacids. The condensation of different types of oxyacid anions is called heteropolyanion, and the acid is called heteropolyacid. At present, it is known that the atoms of nearly 70 kinds of elements can be used as heteroatoms in heteropolyacids, including all the first series transition elements, almost all the second and third series transition elements, plus B, Al, Ga, Si , Ge, Sn, P, As, Sb, Bi, Se, Te, I, etc. And each heteroatom can often exist in heteropolyanions in different valence states, so there are quite ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/131A61P35/00A61K47/58
Inventor 宋宇飞张洁刘秀丽徐福建柴明英
Owner BEIJING UNIV OF CHEM TECH
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