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In vivo self degraded epidural adhesion preventing and composite medicine slow-release biological film

A biofilm and epidural technology, applied in the field of medicine, can solve the problems of epidural hematoma, increase the pain of patients, and reduce the treatment effect.

Inactive Publication Date: 2002-06-05
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-adhesion membrane (Gore-Tex surgical membrane) made of expanded polytetrafluoroethylene in the spinal canal (Gore-Tex surgical membrane) has been tested and applied clinically. , so it remains in the body as a foreign body for a long time, often resulting in epidural hematoma due to the movement of the diaphragm
[0004] For patients with malignant tumors of the spine and spinal cord, drug chemotherapy is often required for several months after surgery; for patients with spinal cord injury, usually after surgical treatment, daily intramuscular injection of neurotrophic drug methylcobalamin 500ug is required to maintain 1-2 months of drug treatment, which not only increases the pain of the patient, but also leads to poor drug absorption and reduced therapeutic effect due to long-term intramuscular injection at the same site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Preparation of self-degradable anti-epidural adhesion biofilm

[0015] Add 3 grams of racemic polylactic acid and 1 gram of chitin passed through a 200-mesh sieve into 8ml of acetone, mix well and spread it on a 50mm 2 In a flat-bottomed container, the acetone is completely volatilized to form an anti-epidural biojunction film with a thickness of about 0.4 mm, which is cut into 3×6 (mm) sheets, sterilized by ethylene oxide, and vacuum-sealed for storage for later use.

Embodiment 2

[0016] Example 2: Preparation of self-degradable anti-epidural adhesion composite methylcobalamin biofilm

[0017] Add 3 grams of racemic polylactic acid and 0.5 grams of chitin passed through a 200-mesh sieve into 8ml of acetone, add 1mg of methylcobalamin in the dark, mix well and spread it on a 50mm 2 In a flat-bottomed container, completely volatilize acetone to form a composite methylcobalamin biofilm with a thickness of about 0.4 mm, cut into 3×6 (mm) sheets, sterilize with ethylene oxide, and vacuum seal to avoid light Save for later.

Embodiment 3

[0018] Example 3: Preparation of self-degradable anti-epidural adhesion composite 5-fluorouracil biofilm

[0019] 0.5 g of chitin and 1.2 g of 5-fluorouracil passed through a 200-mesh sieve were added to 3 g of racemic polylactic acid in a molten state. Mix well and spread on 50mm 2 In a flat-bottomed container, after cooling, make a composite 5-fluorouracil biofilm with a thickness of about 0.4 mm, cut into 3×6 (mm) sheets, sterilize with ethylene oxide, and store in a vacuum seal for later use.

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Abstract

The present invention relates to the field of medicine technology. The in-vivo self-degradable epitradural adhesion prevention and its composite medicine slow-releasing biological film are prepared with chitin and polylactic acid and serves to prevent adhesion, and the medicines in the composite film, such as nutrient medicine, chemotherapeutic drug and antiphlogistic are locally slow-released. The biological film can be degraded and absorbed with in the body.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to an in vivo self-degradation anti-epidural adhesion and its compound medicine slow-release biofilm for spinal laminectomy. Background technique [0002] Laminectomy is one of the most commonly used surgical methods in spine surgery. The local defect caused by laminectomy is repaired by fibrous connective tissue hyperplasia, and undergoes basic pathological processes such as inflammation, granulation tissue, and scar tissue formation. The basis is a series of activities of inflammatory cells and repair cells. Scar tissue hyperplasia and adhesion formation in the spinal canal are important causes of failed lumbar surgery syndrome, which seriously affect the therapeutic effect of spinal surgery. An ideal anti-adhesion material should have the following characteristics: 1. Good biocompatibility, no cytotoxicity, no local or systemic damage, and no obvious immune rejection; 2. Biodegra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L33/08
Inventor 叶晓健吕宏李家顺贾连顺
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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