In vivo self degraded epidural adhesion preventing and composite medicine slow-release biological film

Abstract

The present invention relates to the field of medicine technology. The in-vivo self-degradable epitradural adhesion prevention and its composite medicine slow-releasing biological film are prepared with chitin and polylactic acid and serves to prevent adhesion, and the medicines in the composite film, such as nutrient medicine, chemotherapeutic drug and antiphlogistic are locally slow-released. The biological film can be degraded and absorbed with in the body.

Description

technical field

[0001] The invention relates to the technical field of medicine, and relates to an in vivo self-degradation anti-epidural adhesion and its compound medicine slow-release biofilm for spinal laminectomy. Background technique

[0002] Laminectomy is one of the most commonly used surgical methods in spine surgery. The local defect caused by laminectomy is repaired by fibrous connective tissue hyperplasia, and undergoes basic pathological processes such as inflammation, granulation tissue, and scar tissue formation. The basis is a series of activities of inflammatory cells and repair cells. Scar tissue hyperplasia and adhesion formation in the spinal canal are important causes of failed lumbar surgery syndrome, which seriously affect the therapeutic effect of spinal surgery. An ideal anti-adhesion material should have the following characteristics: 1. Good biocompatibility, no cytotoxicity, no local or systemic damage, and no obvious immune rejection; 2. Biodegra...