Composite drug carrier based on metal nanoparticles and microgel and application thereof

A metal nanoparticle and nanoparticle technology, applied in the field of biomedical nanomaterials, can solve problems such as complex synthesis process and troublesome compounding conditions, and achieve high encapsulation efficiency, fast thermal response, good biocompatibility and efficient thermal response sexual effect
CN108743564AActive Publication Date: 2018-11-06SOUTHEAST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHEAST UNIV
Publication Date
2018-11-06

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Abstract

The invention discloses a composite drug carrier based on metal nanoparticles and microgel and an application thereof. The composite drug carrier is formed by precious metal nanoparticles and attachedthermal response polymer gel microspheres skeleton, and the attached thermal response polymer gel microspheres skeleton is the skeleton formed by poly (N-isopropyl acrylamide)PNIPAM microspheres; andthe precious metal nanoparticles are gold nanospheres. The carrier is used on drug release and combined photo-thermal treatment; The nano gold is used for coating invasive microgel to change the surface chemistry of the microgel, a composite drug-loaded system is constructed, the nano gold has good biological compatibility and efficient thermal responsiveness, can achieve drug thermal response controlled release, has combined photo-thermal treatment effect, and achieves a drug combined treatment purpose.
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Description

technical field

[0001] The invention relates to the technical field of biomedical nanomaterials, in particular to a composite drug carrier based on metal nanoparticles and its application. Background technique

[0002] Micro-nano-sized polymer microgels have excellent biocompatibility, soft and mesh-like structure simulating extracellular matrix (ECM), and multiple external stimulus response properties (temperature, light, pH, etc.), and have been discovered since At the beginning, it has attracted extensive attention from the academic community. A large number of microgels with controllable responses to different stimuli have been synthesized, which provides a significant and widely used good for the fields of biomedicine, drug delivery, targeting carriers and nanoreactors. Smart Materials. On the other hand, polymetallic composites with different morphologies and multimetal complexes can now be synthesized on a large scale, and their morphologies and sizes can be effectiv...

Claims

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