A composite drug carrier based on metal nanoparticles and microgel and its application

A metal nanoparticle and nanoparticle technology, applied in the field of biomedical nanomaterials, can solve problems such as complex synthesis process and troublesome compounding conditions, and achieve high encapsulation efficiency, good system stability, and excellent drug loading effect

Active Publication Date: 2021-11-02
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The gel microspheres and gold nanoparticles in the drug-loading system of the present invention are recombined through physical trapping and chemical bonds; the disadvantages of complex synthesis process and troublesome compounding conditions in most similar drug-loading systems are solved, and through simple and effective temperature control compounding can be carried out efficiently

Method used

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  • A composite drug carrier based on metal nanoparticles and microgel and its application
  • A composite drug carrier based on metal nanoparticles and microgel and its application
  • A composite drug carrier based on metal nanoparticles and microgel and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1: A method for preparing a composite drug carrier based on metal nanoparticles and microgel.

[0031] 1) Add 1.4g NIPAM and 0.14g BIS to 100mL ultrapure water, stir at high speed under a nitrogen atmosphere and heat to 70°C, slowly add 74mM KPS solution dropwise with a dropping funnel. After reacting for 4 hours, it was cooled to room temperature, and purified by dialysis to obtain PNIPAM microspheres with a particle size of 450nm±20nm, which were diluted 30 times with ultrapure water before use.

[0032] 2) Evaporate the PNIPAM solution purified by dialysis to dryness at 70°C to powder, add an equal volume of 0.2 mg / mL DOX aqueous solution, stir at a medium speed at 4°C for 48 hours, and then centrifuge to separate the PNIAM microspheres loaded with DOX ( PNIPAM-DOX), dissolved in ultrapure water with the same volume as the added solution, for the next step of attaching gold nanoparticles.

[0033] 3) Add 2mL 25mM HAuCl to 168mL ultrapure water 4 Aqueous sol...

Embodiment 2

[0035] Embodiment 2: comparative test

[0036] Using the same steps as in Example 1, improve the HAuCl 4 For the molar ratio of sodium citrate, 12AS was replaced by 45nmAS, and the volume ratio of 45AS and PNIPAM microspheres was adjusted to 2, and the compounding times were increased to 5 times. Prepare 45AS-PNIPAM-DOX by the method identical with embodiment 1; Concrete result is as follows figure 2 shown.

[0037] From figure 2It can be seen from the above: the product obtained by the method in this embodiment, that is, when the AS particle size increases to 45nm, the final product can still wrap the PNIPAM microspheres well, and the expected effect can be obtained.

Embodiment 3

[0038] Embodiment 3: comparative test

[0039] Using the same steps as in Example 1, replacing the gold nanoparticles with gold nanorods AR with a particle diameter aspect ratio of 1.4, the same method as in Example 1 was used to prepare AR-PNIPAM-DOX; the specific results are as follows figure 2 shown.

[0040] From figure 2 It can be seen that: adopt the product that the method in the present embodiment makes, because the topography of AR is not highly symmetrical structure, make it with the area that PNIPAM microsphere is wrapped and expose larger, make it decline to the property change of PNIPAM microsphere .

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Abstract

The invention discloses a composite drug carrier based on metal nanoparticles and microgel and its application. The composite drug carrier is composed of noble metal nanoparticles and the attached thermo-responsive polymer gel microsphere skeleton. The thermo-responsive polymer The gel microsphere skeleton is a skeleton composed of poly(N-isopropylacrylamide) PNIPAM microspheres; the noble metal nanoparticles are gold nanospheres; the application of the carrier of the present invention in drug release and combined photothermal therapy; the present invention The surface chemistry of the microgel is changed by wrapping the invading microgel with gold nanoparticles, and a composite drug-loading system is constructed, which has good biocompatibility and high thermal responsiveness. Play the role of combined photothermal therapy to achieve the purpose of drug combination therapy.

Description

technical field [0001] The invention relates to the technical field of biomedical nanomaterials, in particular to a composite drug carrier based on metal nanoparticles and its application. Background technique [0002] Micro-nano-sized polymer microgels have excellent biocompatibility, soft and mesh-like structure simulating extracellular matrix (ECM), and multiple external stimulus response properties (temperature, light, pH, etc.), and have been discovered since At the beginning, it has attracted extensive attention from the academic community. A large number of microgels with controllable responses to different stimuli have been synthesized, which provides a significant and widely used good for the fields of biomedicine, drug delivery, targeting carriers and nanoreactors. Smart Materials. On the other hand, polymetallic composites with different morphologies and multimetal complexes can now be synthesized on a large scale, and their morphologies and sizes can be effectiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/32A61K47/02A61K31/704A61P35/00
CPCA61K9/5115A61K9/5138A61K31/704A61P35/00
Inventor 陈怡周正严玲琳时画顾宁
Owner SOUTHEAST UNIV
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