Sulbactam sodium bacteriophage complex and the preparing method thereof

A technology of sulbactam sodium and preparation process, which is applied in the field of sulbactam sodium antibiotic compound and its preparation process, and can solve the problems of relatively large difference in elimination half-life between antibiotics and sulbactam sodium, kidney damage, and easy oxidation of sulbactam sodium To achieve the effect of prolonging the elimination half-life, reducing toxic effects, and reducing allergic reactions

Inactive Publication Date: 2007-10-31
HUNAN KANGDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems that the above-mentioned sulbactam sodium is easy to oxidize, the elimination half-life of antibiotics and sulbactam sodium is quite different, and the drug is ea...

Method used

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  • Sulbactam sodium bacteriophage complex and the preparing method thereof
  • Sulbactam sodium bacteriophage complex and the preparing method thereof
  • Sulbactam sodium bacteriophage complex and the preparing method thereof

Examples

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Embodiment 1

[0043] The present embodiment adopts the mouse of respiratory tract infection disease model as experimental animal, carries out comparative experiment with the mixture of sulbactam sodium antibiotic complex provided by the present invention and 100g piperacillin sodium / 400g sulbactam sodium respectively, compares grouping, 100 in each group, weighing 18-20g.

[0044] The raw materials that present embodiment adopts and the parts by weight of each raw material are as follows:

[0045] Piperacillin Sodium 100;

[0046] Sulbactam sodium 400;

[0047] Liposome 15;

[0048] Polyvinylpyrrolidone 15;

[0049] Reduced Glutathione 4.

[0050] The preparation method is as follows:

[0051] 1) Get the above-mentioned liposome solution containing 15g liposome.

[0052] 2) Add 100g of piperacillin sodium and 400g of sulbactam sodium into the liposome solution, and stir ultrasonically (the time of ultrasonic treatment should be less than 45 minutes, the treatment temperature should be...

Embodiment 2

[0062] The present embodiment adopts the mouse of soft tissue infectious disease model as experimental animal, carries out comparative experiment with the sulbactam sodium antibiotic complex provided by the present invention and 400g amoxicillin sodium / 200g sulbactam sodium mixture respectively, compares grouping, each Group 100, body weight 18-20g.

[0063] The raw materials that present embodiment adopts and the parts by weight of each raw material are as follows:

[0064] Amoxicillin sodium 400;

[0065] Sulbactam Sodium 200;

[0066] Liposome 250;

[0067] Polyvinylpyrrolidone 250;

[0068] Reduced Glutathione 0.5.

[0069] The preparation method is as follows:

[0070] 1) Get the above-mentioned liposome solution containing 250g liposome.

[0071] 2) Add 400g of amoxicillin sodium and 200g of sulbactam sodium into the liposome solution, and stir ultrasonically (the time of ultrasonic treatment should be less than 45 minutes, the treatment temperature should be lower t...

Embodiment 3

[0080] The present embodiment adopts the mouse of wound infection disease model as experimental animal, carries out comparative experiment with the sulbactam sodium antibiotic complex provided by the present invention and 200g cefoperazone sodium / 100g sulbactam sodium mixture respectively, compares grouping, every group 100 only, weighing 18-20g.

[0081] The raw materials that present embodiment adopts and the parts by weight of each raw material are as follows:

[0082] Cefoperazone Sodium 200;

[0083] Sulbactam Sodium 100;

[0084] Liposome 15;

[0085] Polyvinylpyrrolidone 15;

[0086] Reduced Glutathione 2.

[0087] The preparation method is as follows:

[0088] 1) Get the above-mentioned liposome solution containing 15g liposome.

[0089] 2) Add 200g of cefoperazone sodium and 100g of sulbactam sodium into the liposome solution, and dissolve under ultrasonic stirring (the time of ultrasonic treatment should be less than 45 minutes, the treatment temperature should...

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Abstract

The invention discloses a diastole bar apron sodium antibiotics and preparing craft, which is characterized by the following: allocating with mass ratio as 100-400 antibiotics, 100-400 diastole bar apron sodium, 10-300 liposome and 10-300 polyvinyl pyrrolidon; keeping the drug-effect of common diastole bar apron sodium antibiotics compound; prolonging nullifying half-decay time of the antibiotics; adding antioxidant into composite drug; increasing stability of the drug. This invention can prolongs the effective time of the drug.

Description

technical field [0001] The invention relates to a sulbactam sodium antibiotic complex and a preparation process thereof. Background technique [0002] The application of antibiotics has completely overcome the situation that bacterial diseases are difficult to treat. However, due to the rapid mutation rate of bacteria and the widespread application of antibiotics, more and more bacteria are resistant to clinically used antibiotics, which seriously affects the therapeutic effect of bacterial diseases. In order to solve the problem of bacterial drug resistance, the combination of antibiotics and β-lactamase inhibitor sulbactam (sulbactam) has been used clinically, and good results have been achieved. On this basis, a large number of combination drugs of antibiotics and sulbactam sodium have also begun to appear. [0003] The current combined drug of antibiotics and sulbactam sodium only solves the problem of the proportioning of antibiotics and sulbactam sodium, thereby solv...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/04A61K9/19A61P31/04
Inventor 蔡海德
Owner HUNAN KANGDU PHARMA
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