Preparation method of composite drug-eluting stent and its drug coated layer

Abstract

The invention discloses a making method of drug coating on the elution rack, which comprises the following steps: dissolving vitamin A acid drug and polymer in the organic solvent to obtain the coating liquid of vitamin A acid; coating the liquid on the predisposed metal rack surface; evaporating solvent; obtaining the buried vitamin A acid coating; dissolving estrogen drug and polymer in the organic solvent to obtain estrogen coating liquid; coating on the surface of estrogen coating liquid; evaporating; obtaining the product; or dissolving vitamin A acid, estrogen drug and polymer in the organic solvent to obtain the composition of drug and polymer; coating on the predisposed metal rack surface; evaporating; burying in the drug coating of vitamin A acid and estrogen.

Description

[technical field]

[0001] The invention relates to the field of medical drug eluting stents, in particular to the drug coating on the eluting stents. [Background technique]

[0002] In recent years, with the improvement of living standards and changes in lifestyle, cardiovascular diseases represented by atherosclerosis have become the primary factor threatening life. For patients with moderate and moderate coronary heart disease, interventional therapy using percutaneous coronary angioplasty (PTCA) and stenting (stenting) has the advantages of small trauma, fast recovery, and wide application range, and is becoming the current coronary heart disease. Hotspots in heart disease treatment.

[0003] However, the occurrence of postoperative restenosis is the primary problem faced by interventional therapy. According to statistics, the incidence of restenosis after PTCA and stent implantation is 30-30% respectively after percutaneous coronary angioplasty (PTCA) and bare metal sten...

Examples

Embodiment 1

[0029]Weigh an appropriate amount of all-trans retinoic acid and PLA respectively according to a weight ratio of 1:4, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The retinoic acid coating solution is sprayed onto the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain a retinoic acid layer coating. Appropriate amounts of estradiol and PLA were weighed at a weight ratio of 1:4, dissolved in tetrahydrofuran to a solid content of 1%. The estradiol coating solution is sprayed onto the outside of the retinoic acid coating of the stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain an all-trans retinoic acid estradiol composite eluting stent 1 .

Embodiment 2

[0031] Weigh an appropriate amount of all-trans retinoic acid and polyacrylic acid resin silica nanocomposite material respectively according to the weight ratio of 4:6, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The retinoic acid coating solution is sprayed onto the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain a retinoic acid layer coating. Weigh an appropriate amount of estradiol and polyacrylic acid resin silicon dioxide nanocomposite material respectively according to a weight ratio of 3:7, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The estradiol coating solution is sprayed onto the outside of the retinoic acid coating of the stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain an all-trans retinoic acid estradiol composite eluting stent 2 .

Embodiment 3

[0033] Weigh appropriate amount of all-trans retinoic acid, estradiol and polyacrylic resin silicon dioxide nanocomposite material respectively according to the weight ratio of 1:1:3, dissolve with tetrahydrofuran and set the volume to 1% solid content. Spray the mixed drug coating solution on the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cure and dry in a vacuum at room temperature to obtain a mixed drug coating. Weigh an appropriate amount of polyacrylic resin silica nanocomposite material, and use tetrahydrofuran ultrasonic Dissolving to obtain a 0.5% coating solution by weight. Using the aforementioned coating method, the polyacrylic acid resin silica nano-coating solution is applied to the surface of the drug stent coated with the all-trans retinoic acid estradiol layer coating to obtain the all-trans retinoic acid estradiol composite eluting stent 3 .

[technical field]

[0001] The invention relates to the field of medical drug eluting stents, in particular to the drug coating on the eluting stents. [Background technique]

[0002] In recent years, with the improvement of living standards and changes in lifestyle, cardiovascular diseases represented by atherosclerosis have become the primary factor threatening life. For patients with moderate and moderate coronary heart disease, interventional therapy using percutaneous coronary angioplasty (PTCA) and stenting (stenting) has the advantages of small trauma, fast recovery, and wide application range, and is becoming the current coronary heart disease. Hotspots in heart disease treatment.

[0003] However, the occurrence of postoperative restenosis is the primary problem faced by interventional therapy. According to statistics, the incidence of restenosis after PTCA and stent implantation is 30-30% respectively after percutaneous coronary angioplasty (PTCA) and bare metal sten...

Examples

Embodiment 1

[0029]Weigh an appropriate amount of all-trans retinoic acid and PLA respectively according to a weight ratio of 1:4, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The retinoic acid coating solution is sprayed onto the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain a retinoic acid layer coating. Appropriate amounts of estradiol and PLA were weighed at a weight ratio of 1:4, dissolved in tetrahydrofuran to a solid content of 1%. The estradiol coating solution is sprayed onto the outside of the retinoic acid coating of the stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain an all-trans retinoic acid estradiol composite eluting stent 1 .

Embodiment 2

[0031] Weigh an appropriate amount of all-trans retinoic acid and polyacrylic acid resin silica nanocomposite material respectively according to the weight ratio of 4:6, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The retinoic acid coating solution is sprayed onto the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain a retinoic acid layer coating. Weigh an appropriate amount of estradiol and polyacrylic acid resin silicon dioxide nanocomposite material respectively according to a weight ratio of 3:7, dissolve them in tetrahydrofuran and set the volume to a solid content of 1%. The estradiol coating solution is sprayed onto the outside of the retinoic acid coating of the stent by using an atomizing spraying device, and then cured and dried in a vacuum at room temperature to obtain an all-trans retinoic acid estradiol composite eluting stent 2 .

Embodiment 3

[0033] Weigh appropriate amount of all-trans retinoic acid, estradiol and polyacrylic resin silicon dioxide nanocomposite material respectively according to the weight ratio of 1:1:3, dissolve with tetrahydrofuran and set the volume to 1% solid content. Spray the mixed drug coating solution on the surface of the pretreated bare metal stent by using an atomizing spraying device, and then cure and dry in a vacuum at room temperature to obtain a mixed drug coating. Weigh an appropriate amount of polyacrylic resin silica nanocomposite material, and use tetrahydrofuran ultrasonic Dissolving to obtain a 0.5% coating solution by weight. Using the aforementioned coating method, the polyacrylic acid resin silica nano-coating solution is applied to the surface of the drug stent coated with the all-trans retinoic acid estradiol layer coating to obtain the all-trans retinoic acid estradiol composite eluting stent 3 .

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