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Copper telluret nanometer compound medicine granules for thermal chemotherapy and method for constructing copper telluret nanometer compound medicine granules

A nano-composite and nano-particle technology, applied in the field of nano-material preparation and biomedicine, can solve problems such as poor single treatment effect, achieve strong photothermal conversion efficiency, improve treatment effect, and overcome the effect of poor effect.

Inactive Publication Date: 2016-09-28
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a copper telluride nano-composite drug particle for thermal chemotherapy and its construction method to solve the problem of poor single treatment effect in the traditional clinical process

Method used

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  • Copper telluret nanometer compound medicine granules for thermal chemotherapy and method for constructing copper telluret nanometer compound medicine granules
  • Copper telluret nanometer compound medicine granules for thermal chemotherapy and method for constructing copper telluret nanometer compound medicine granules
  • Copper telluret nanometer compound medicine granules for thermal chemotherapy and method for constructing copper telluret nanometer compound medicine granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation of Copper Telluride Nanoparticles Encapsulated by Oleic Acid

[0028] In a glove box, mix 0.256 g of tellurium powder and 2 mL of trioctylphosphine solution in a 10 mL one-necked flask, raise the temperature to 200 ° C under magnetic stirring and keep it for 2 h, and let it cool down to room temperature naturally to obtain 1 mol / L tellurium The trioctylphosphine solution is ready for use.

[0029] Put 1mmol copper acetylacetonate, 10mL oleic acid and 5mL n-dodecanethiol into a 50mL three-neck flask, raise the temperature to 180°C under magnetic stirring and nitrogen protection, and keep it for 10min to obtain a clear reddish-brown solution; Subsequently, 0.5 mL of tellurium-trioctylphosphine solution with a concentration of 1 mol / L was injected thereinto, and the solution turned black instantly, and reacted at this temperature for 2 minutes, and copper telluride nanoparticles coated with oleic acid were obtained.

[0030] Such as figure 2 a show...

Embodiment 2

[0032] Preparation of Copper Telluride Nanoparticles Modified by Example 2 Phospholipid Polyethylene Glycol

[0033] Take a toluene solution containing 5 mg of oleic acid-coated copper telluride nanoparticles, then add a chloroform solution containing 5 mg of phospholipid polyethylene glycol, and ultrasonicate for 10 minutes to fully dissolve the phospholipid polyethylene glycol; vacuum rotary evaporation to remove the organic solvent, forming A layer of green film, then add 5mL of phosphate buffer and sonicate for 5min, so that the film is evenly dispersed in the buffer, and the copper telluride nanoparticles modified by phospholipid polyethylene glycol are obtained.

[0034] figure 2 b is a transmission electron micrograph of copper telluride nanoparticles modified with phospholipid polyethylene glycol, the average particle size of which is 5-20 nm.

[0035] The copper telluride nanoparticles modified by phospholipid polyethylene glycol were dispersed in water to obtain so...

Embodiment 3

[0040] Example 3 Preparation of Copper Telluride Nanocomposite Drug Particles

[0041] Take the toluene solution containing 3 mg oleic acid-coated copper telluride nanoparticles, add a chloroform solution containing 3 mg phospholipid polyethylene glycol, then add a mixed solution of chloroform and methanol containing 0.3 mg hydrophobic doxorubicin, and ultrasonically 15 min to make it Mix completely; reduce the organic solvent by rotary evaporation under reduced pressure to form a thin film; then add 3 mL of phosphate buffer, and sonicate for 5 min to obtain the copper telluride nanocomposite drug particles loaded with doxorubicin.

[0042] Figure 9 A solution of doxorubicin in chloroform with a concentration of 30 μg / mL, an aqueous solution of copper telluride nanoparticles modified with phospholipid polyethylene glycol at a concentration of 300 μg / mL, and an aqueous solution of copper telluride nanocomposite drug particles loaded with doxorubicin at a concentration of 300 μ...

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Abstract

The invention discloses a copper telluride nanocomposite drug particle for thermal chemotherapy and a construction method thereof. Hydrophobic drugs; the surface of nanocomposite drug particles is modified with amphiphilic molecules. The copper telluride nanoparticles coated with oleic acid of the present invention can not only be used as a material for photothermal therapy of tumors, and can effectively kill cancer cells at a lower laser intensity and lower concentration; but also can be used as a drug carrier, thereby realizing The synergistic treatment of thermal chemotherapy can effectively improve the efficiency of tumor treatment; therefore, copper telluride nanoparticles have broad application prospects in drug delivery and tumor treatment.

Description

technical field [0001] The invention belongs to the field of nano material preparation and biomedicine, and in particular relates to a thermochemotherapy drug. Background technique [0002] Cancer has become one of the leading causes of death threatening human health, and its incidence has increased year by year in the last 10 years. Traditional cancer treatment methods are mainly based on surgery, chemotherapy and radiotherapy. However, these treatments are usually accompanied by strong side effects, which will bring great pain to patients, especially after malignant metastasis of cancer cells. Can't heal it. Photothermal therapy converts near-infrared light absorbed by nanomaterials into heat, which increases the local temperature of the tumor site to kill cancer cells. Compared with traditional cancer treatment methods, photothermal therapy is a non-invasive cancer treatment method, which can effectively kill cancer cells without affecting normal tissues, and greatly re...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/704A61K41/00A61K47/02A61P35/00
CPCA61K31/704A61K41/0052
Inventor 查正宝王咸文陈华健
Owner HEFEI UNIV OF TECH
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