Copper telluret nanometer compound medicine granules for thermal chemotherapy and method for constructing copper telluret nanometer compound medicine granules
A nano-composite and nano-particle technology, applied in the field of nano-material preparation and biomedicine, can solve problems such as poor single treatment effect, achieve strong photothermal conversion efficiency, improve treatment effect, and overcome the effect of poor effect.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0027] Example 1 Preparation of Copper Telluride Nanoparticles Encapsulated by Oleic Acid
[0028] In a glove box, mix 0.256 g of tellurium powder and 2 mL of trioctylphosphine solution in a 10 mL one-necked flask, raise the temperature to 200 ° C under magnetic stirring and keep it for 2 h, and let it cool down to room temperature naturally to obtain 1 mol / L tellurium The trioctylphosphine solution is ready for use.
[0029] Put 1mmol copper acetylacetonate, 10mL oleic acid and 5mL n-dodecanethiol into a 50mL three-neck flask, raise the temperature to 180°C under magnetic stirring and nitrogen protection, and keep it for 10min to obtain a clear reddish-brown solution; Subsequently, 0.5 mL of tellurium-trioctylphosphine solution with a concentration of 1 mol / L was injected thereinto, and the solution turned black instantly, and reacted at this temperature for 2 minutes, and copper telluride nanoparticles coated with oleic acid were obtained.
[0030] Such as figure 2 a show...
Embodiment 2
[0032] Preparation of Copper Telluride Nanoparticles Modified by Example 2 Phospholipid Polyethylene Glycol
[0033] Take a toluene solution containing 5 mg of oleic acid-coated copper telluride nanoparticles, then add a chloroform solution containing 5 mg of phospholipid polyethylene glycol, and ultrasonicate for 10 minutes to fully dissolve the phospholipid polyethylene glycol; vacuum rotary evaporation to remove the organic solvent, forming A layer of green film, then add 5mL of phosphate buffer and sonicate for 5min, so that the film is evenly dispersed in the buffer, and the copper telluride nanoparticles modified by phospholipid polyethylene glycol are obtained.
[0034] figure 2 b is a transmission electron micrograph of copper telluride nanoparticles modified with phospholipid polyethylene glycol, the average particle size of which is 5-20 nm.
[0035] The copper telluride nanoparticles modified by phospholipid polyethylene glycol were dispersed in water to obtain so...
Embodiment 3
[0040] Example 3 Preparation of Copper Telluride Nanocomposite Drug Particles
[0041] Take the toluene solution containing 3 mg oleic acid-coated copper telluride nanoparticles, add a chloroform solution containing 3 mg phospholipid polyethylene glycol, then add a mixed solution of chloroform and methanol containing 0.3 mg hydrophobic doxorubicin, and ultrasonically 15 min to make it Mix completely; reduce the organic solvent by rotary evaporation under reduced pressure to form a thin film; then add 3 mL of phosphate buffer, and sonicate for 5 min to obtain the copper telluride nanocomposite drug particles loaded with doxorubicin.
[0042] Figure 9 A solution of doxorubicin in chloroform with a concentration of 30 μg / mL, an aqueous solution of copper telluride nanoparticles modified with phospholipid polyethylene glycol at a concentration of 300 μg / mL, and an aqueous solution of copper telluride nanocomposite drug particles loaded with doxorubicin at a concentration of 300 μ...
PUM
Property | Measurement | Unit |
---|---|---|
Concentration | aaaaa | aaaaa |
The average particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com