Double emulsion core-shell nano-structure and preparation methods thereof

A nano-structure and double-emulsion technology, which can be used in pharmaceutical formulations, emulsion delivery, and medical preparations of non-active ingredients, etc., can solve problems such as unstable structures, difficult control, and complicated manufacturing processes

Inactive Publication Date: 2013-06-05
SPRING FOUND OF NCTU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These organic core-shell nanostructures, for example, have liposomes composed of double fat layers or micelles composed of amphiphilic polymers, but these organic core-shell nanostructures usually have structural instability , or problems such as complicated manufacturing process and difficult control

Method used

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  • Double emulsion core-shell nano-structure and preparation methods thereof
  • Double emulsion core-shell nano-structure and preparation methods thereof
  • Double emulsion core-shell nano-structure and preparation methods thereof

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preparation example Construction

[0058] Preparation method of double-emulsion core-shell nanostructure

[0059] The preparation methods of double-emulsion core-shell nanostructures can be simply divided into single-emulsion method and double-emulsion method.

[0060] Figure 2A It is a schematic flow chart showing the single-emulsion method, which is more suitable for the preparation of double-emulsion core-shell nanostructures containing only hydrophilic drugs or hydrophobic drugs, but is not limited thereto. exist Figure 2A In this process, the aqueous solution (step 210a) and the organic solution (step 210b) are prepared respectively, and the two are mixed and stirred (step 220) to form an emulsion containing double-emulsion core-shell nanostructures (step 230). Next, the organic solvent in the emulsion is removed (step 260) to obtain a double-emulsion core-shell nanostructure suitable for application in living organisms (step 270).

[0061] The aqueous solution in step 210a contains water-soluble poly...

Embodiment 1

[0068] Example 1: Coating hydrophobic paclitaxel (Paclitaxel; PTX)

[0069] according to Figure 2A A single-emulsion method to prepare double-emulsion core-shell nanostructures containing hydrophobic paclitaxel. First prepare the polyvinyl alcohol aqueous solution and the organic solution with a concentration of 0.02 g / ml respectively. The molecular weights of the polyvinyl alcohols used in the above aqueous polyvinyl alcohol solutions are 16,000, 47,000 and 61,000, respectively. The solvent used in the above organic solution is chloroform, and the organic solution contains paclitaxel with a concentration of 0.03g / ml and Fe with a concentration of 0.02g / ml coated with oleic acid (Oleic acid). 3 o 4 Nanoparticles (particle size about 5nm). Fe coated with oleic acid 3 o 4 For the preparation method of nanoparticles (hereinafter referred to as IO-OA nanoparticles), see Sun, S.H.; Zeng, H.; Robinson, D.B.; Raoux, S.; Rice, P.M.; Wang, S.X.; American Chemical Society, 2004,...

Embodiment 2

[0081] Example Two: Coating Hydrophilic Gold Nanorods

[0082] according to Figure 2A A single-emulsion method to prepare double-emulsion core-shell nanostructures containing hydrophilic gold nanorods. The aqueous solution and the organic solution were first prepared separately. The above aqueous solution contains polyvinyl alcohol (molecular weight: 16,000) at a concentration of 0.02 g / ml and excess gold nanorods, and the length of the gold nanorods needs to be smaller than the particle diameter of the carrier. For the preparation method of hydrophilic gold nanorods, please refer to Mitamura, K., Imae, T., Saito, N., and Takai, O., The Journal of Physical Chemistry B 111(30), 8891(2007). The solvent used in the above-mentioned organic solution is chloroform, and the organic solution contains IO-OA nanoparticles (about 5 nm in particle diameter) with a concentration of 0.02 g / ml.

[0083] After mixing 0.5ml of aqueous solution and 0.2ml of organic solution, the mixed solut...

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Abstract

A double-emulsion core-shell nano-structure and preparation methods thereof are provided. The double-emulsion core-shell nano-structure is a structure of an oil shell enclosing a water core. The double-emulsion core-shell nano-structure can be prepared by simply mixing and stirring to emulsify an aqueous solution of a water soluble polymer and an organic solution of hydrophobic paramagnetic nanoparticles

Description

technical field [0001] The invention relates to a nanostructure and its preparation method, and in particular to a double-emulsion core-shell nanostructure and its preparation method. Background technique [0002] At present, some core-shell nanostructures made of organic materials have been applied to carry drugs as drug carriers. These organic core-shell nanostructures, for example, have liposomes composed of double fat layers or micelles composed of amphiphilic polymers, but these organic core-shell nanostructures usually have structural instability , or problems such as complicated manufacturing process and difficult control. Contents of the invention [0003] Therefore, one aspect of the present invention is to provide a double-emulsion core-shell nanostructure, which can be prepared only by a simple emulsification method using a single mixing method. [0004] The aforementioned double-emulsion core-shell nanostructure consists of an oil-phase shell surrounding a wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/32
CPCA61K9/5138A61K9/5094A61K41/0028A61K9/107A61K9/5123A61K9/113A61K47/32
Inventor 廖邦杰胡尚秀陈三元
Owner SPRING FOUND OF NCTU
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