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Prepn. of magnetic molecular pellets by complex emulsion process (W1/0/W2 type)

A polymer microsphere and polymer technology, applied in the field of magnetic polymer microspheres and their preparation, can solve problems such as limiting the application of magnetic polymer microspheres

Inactive Publication Date: 2006-09-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the introduction of the existing preparation methods above, it is not difficult to see that the microspheres prepared by none of the existing methods can meet the requirements of ideal microspheres, which also limits the application of magnetic polymer microspheres in medical and biological separation. Applications

Method used

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  • Prepn. of magnetic molecular pellets by complex emulsion process (W1/0/W2 type)
  • Prepn. of magnetic molecular pellets by complex emulsion process (W1/0/W2 type)
  • Prepn. of magnetic molecular pellets by complex emulsion process (W1/0/W2 type)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 0.30 g of PSt and 0.06 g of Span85 (sorbitan trioleate) and dissolve them in 6.50 mL of toluene to form oil phase O. Will W 1 (0.40mL of FeCl with a concentration of 1.00mol / L 3aqueous solution and 0.20ml of FeSO with a concentration of 1.00mol / L 4 Aqueous solution) was added to the oil phase O, stirred with an emulsifying homogenizer for 2min at a speed of 10000rpm to form a stable W 1 / O colostrum emulsion. The prepared W 1 / O type colostrum emulsion is slowly poured into 250mL external water phase W 2 (H 2 O is 250.0g, PVA-217 is 1.0g), stirring in the rotating speed is 400rpm, forming W 1 / O / W 2 Type double emulsion, then add 50mL triethylamine to the external water phase, stir for 2hr under nitrogen protection, then raise the temperature to 45°C and stir for 6hr, then naturally cool down to room temperature and stir for 18hr to completely volatilize the toluene. Finally, it is separated in an external magnetic field, washed, and vacuum-dried to obtain ...

Embodiment 2

[0038] Take 0.30 g of PSt and 0.06 g of Aracel83 (sorbitan sesquioleate), and dissolve them in 6.00 mL of dichloromethane to form oil phase O. Will W 1 (0.30mL of FeCl with a concentration of 0.80mol / L 3 aqueous solution and 0.3ml of FeCl with a concentration of 0.80mol / L 2 aqueous solution) into the oil phase O, emulsified by ultrasonic emulsification, the emulsification power is 200W, and the time is 2min to form a stable W 1 / O colostrum emulsion. The prepared W 1 / O type colostrum emulsion is slowly poured into 350mL external water phase W 2 (H 2 O is 350.0g, PVA-217 is 1.75g), stirring in the rotating speed is 400rpm, forming W 1 / O / W 2 Type double emulsion, then add 25mL potassium hydroxide solution with a concentration of 2mol / L to the external water phase, stir for 2hr under the protection of nitrogen, then naturally cool down to room temperature and stir for 24hr to completely volatilize the dichloromethane. Finally, it is separated in an external magnetic fie...

Embodiment 3

[0040] Take 0.30 g of PSt and 0.08 g of Span85 (sorbitan trioleate) and dissolve them in 5.50 mL of toluene and 1.00 mL of dichloromethane to form oil phase O. Will W 1 (0.30mL of FeCl with a concentration of 0.50mol / L 3 aqueous solution and 0.30ml of FeCl with a concentration of 0.50mol / L 2 Aqueous solution) was added to the oil phase O, stirred with an emulsifying homogenizer for 2min, and the speed was 9000rpm to form a stable W 1 / O colostrum emulsion. The prepared W 1 / O type colostrum emulsion is slowly poured into 300mL external water phase W 2 (H 2 O is 300.0g, PVA-217 is 3.0g), stir with a homogeneous emulsifier, the speed is 600rpm, and form W 1 / O / W 2 Type double emulsion emulsion, then use mechanical stirring, the speed is 400rpm, then add 50mL triethylamine to the external water phase, stir for 2hr under the protection of nitrogen, then raise the temperature to 45°C and stir for 6hr, and then reduce the pressure to make the toluene and diethylamine Chlorom...

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Abstract

This invention provides a method to prepare a kind of new magnetic polymer microballs, in which a double emulsion method is employed and the obtained magnetic polymer microballs have a particle size range of 50nm~80micron. The magnetic particles embedded in the microballs have a mass fraction of 0.5~50% of the total microballs. The main technique flow includes the preparation of initial emulsion, reemulsification, addition of alkali, removal of organic solvent, solidification of second emulsion drops, washing and separation of magnetic microballs and drying of microballs. It has the characteristics that double emulsions embedded with ferrous salt solution are prepared by the double emulsion method at first and organic or inorganic alkali is added so that ferrous salts are transferred into magnetic particles. Double emulsion drops are then solidified so as to produce magnetic polymer microballs. The particle size of the microballs can be adjusted by modulating the viscosity of initial emulsion, the rotation speed of outer aqueous phase when reemulsification and the concentration of outer aqueous phase stabilizers, while the magnet content can be adjusted by modulating solute concentration in inner aqueous phase and the volume ratio of inner aqueous phase and oil phase. The magnetic microballs can serve as carriers for all kinds of enzymes, antibodies and target drugs and are widely used in the fields of cell separation, clinical diagnosis, target drug carries, immobilized enzymes and affinity separation. This invention has the advantages of simple method, good repeatability, high raw materials availability, low cost, controllable particle size of microballs and uniform and controllable magnet content in microballs.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to magnetic polymer microspheres with magnetism and a preparation method thereof. technical background [0002] Magnetic polymer microspheres refer to embedding magnetic particles in polymer microspheres by appropriate methods to form microspheres with certain magnetic responsiveness and special structure. It is a new type of functional polymer composite material developed in the late 1970s. On the one hand, it has the characteristics of polymer microspheres. Through chemical reactions such as copolymerization and surface modification, the surface of polymer microspheres can be equipped with a variety of functional groups, so that it can bind a variety of biologically active substances; on the other hand, it It is also magnetic, and can be quickly separated from other non-magnetic substances under an external magnetic field, and the energy consumption is small...

Claims

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Application Information

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IPC IPC(8): C08F12/08C08F2/44C08F2/32C08K3/24
Inventor 马光辉苏志国杨建
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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