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Method for preparing faveolate polymer microsphere on basis of micro-fluidic chip

A microfluidic chip and polymer technology, applied in chemical instruments and methods, educts, laboratory containers, etc., can solve the problems of unsatisfactory synthesis requirements, poor shape controllability, poor monodispersity, etc., to achieve The shape and size are controllable, the process is simple and fast, and the effect of environmental friendliness

Active Publication Date: 2013-10-30
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

[0003] Traditional methods for preparing polymer microspheres include stirring emulsification, spray drying, gelation, hot melting, etc. Most of them have the disadvantages of poor monodispersity, poor shape controllability, and multi-step time-consuming.
For functional materials with special morphology, traditional methods cannot meet their synthesis needs to a large extent.

Method used

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  • Method for preparing faveolate polymer microsphere on basis of micro-fluidic chip
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  • Method for preparing faveolate polymer microsphere on basis of micro-fluidic chip

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Embodiment 1

[0026] Preparation and modification of microfluidic chip: Based on soft lithography technology, a PDMS layer containing microchannel patterns is prepared, and the microfluidic chip is obtained by irreversible sealing with the glass substrate. Pour polyvinyl alcohol-glycerol mixed solution into the chip, after a period of molecular adsorption, the surface of the channel is modified with hydrophilic groups, so as to ensure the double emulsion phase (W 1 / O / W 2 ) droplet formation.

[0027] The preparation of reaction precursor liquid: effervescent agent ammonium bicarbonate inorganic salt is dissolved in water as internal water phase (W 1 ) (10%, 5%, 1%, wt%), the polymer polylactic acid-glycolic acid is dissolved in the organic solvent dimethyl carbonate as the oil phase (O) (PLGA viscosity is 1.64dL / g, 1.6%, wt %), ice-bath ultrasonic dispersion to obtain water-in-oil colostrum phase (W 1 / O); external water phase (W 2 ) is an aqueous solution (2%, wt%) containing surfacta...

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Abstract

The invention relates to a method for preparing a faveolate polymer microsphere on the basis of a micro-fluidic chip. The method comprises the following steps that: an initial emulsion phase (W1 / O) obtained through ultrasonic dispersion is used as a dispersed phase, and double-emulsion phase (W1 / O / W2) liquid drops inside the micro-fluidic chip are formed under the action of a continuous phase (W2); and an effervescing agent dissolved in an inner water phase (W1) is decomposed to play an expanding role, and a polymer dissolved in an oil phase is separated out and solidified with the volatilization of a solvent and deposited on the periphery of an inner water phase (W1) liquid drop mould plate to form the polymer microsphere with a unique structure. The micro-fluidic chip based on a liquid drop operation and control technology is designed and manufactured, and the micro-fluidic chip is applied to preparation of a monodisperse polylactic acid-hydroxyacetic acid copolymer microsphere with a specific bionic faveolate structure. The method is characterized by preparing microspheres with different sizes and patterns by regulating the concentration of the effervescing agent inside the inner water phase (W1). The method disclosed by the invention has the advantages of easiness and fastness for preparation and has an extremely high potential application capacity in the fields of pharmacy and tissue engineering.

Description

technical field [0001] The invention relates to a method for preparing polymer microspheres, in particular to a method for preparing honeycomb polymer microspheres based on a microfluidic chip. Background technique [0002] Polymer microspheres refer to polymer particles with a spherical structure and a size on the order of microns. Since the size, composition and morphology of polymer microspheres can be adjusted in many parameters, they have multifunctional application characteristics and have attracted much attention. It has been widely used in the fields of physics, chemistry, biology and medicine, such as optoelectronics, chromatographic technology, tissue engineering and drug sustained release system. [0003] Traditional methods for preparing polymer microspheres include stirring emulsification, spray drying, gelation, hot melting, etc. Most of them have the disadvantages of poor monodispersity, poor shape controllability, and multi-step time-consuming. For function...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/08C08J3/12C08L67/04B01J19/00B01L3/00
CPCY02P20/141
Inventor 秦建华马静云
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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