463 results about "Hydroxyacetic Acids" patented technology

The invention relates to a liraglutide sustained-release micro sphere preparation and a preparation method thereof. The liraglutide sustained-release microsphere preparation comprises 5mg to 100mg of liraglutide, 0.5mg to 10mg of a protective agent and 50mg to 1000mg of a polylactic acid-glycolic acid copolymer, wherein the protective agent is one or a mixture of a plurality of sucrose, mycose, gelatin, mannitol, glycine, lysine and human serum albumin; the molecular weight of the polylactic acid-glycolic acid copolymer is 5000-20000 Daltons, and the ratio of polylactic acid to glycolic acid in the polylactic acid-glycolic acid copolymer is 1:3 to 3:1. According to the liraglutide sustained-release microsphere preparation disclosed by the invention, regular microspheres and medicines uniformly distributed in the microspheres can be obtained by just emulsifying and volatizing an organic solvent; processing procedures are simple; operation is simple; good repeatability is realized in preparation; the prepared liraglutide sustained-release microsphere preparations in batches have no remarkable difference; the obtained microspheres are uniform in grain size, narrow in distribution, controllable in grain size, round and orderly in surfaces and low in burst release rate.

The invention relates to a neutral blockage removing agent composition used for a mechanical recovery well in an oilfield. The neutral blockage removing agent composition is prepared from the following components in parts by weight: 16-20 parts of polyepoxysuccinic acid amine, 7-12 parts of hydroxyethylidene dipllosphate sodium, 21-25 parts of divinyl pentaacetic acid amine, 20-25 parts of hydroxyl ammonium acetate, 12-16 parts of activated attapulgite, 21-25 parts of ammonium persulfate, 9-12 parts ofdicyclohexyl sulfobutanedioate sodium, 7-9 parts of butyl lactate, 0.2-0.3 part of vanadium pentoxide, 5-8 parts of straight chain sodium dodecylbenzenesulfonate, 10-14 parts of nitrilotriacetic acid sodium salt, 4-7 parts of urotropin and 0.1-0.3 part of glycerin fatty acid ester. The neutral blockage removing agent composition is suitable for scale removal and blockage removal of an oil pumping unit well and a screw pump well, can effectively control the reaction speed of the blockage removing agent and the scale of the oil pumping unit well and the scaled screw pump well, and prevent the falling-off of big scale residues to result in the secondary blockage of the mechanical recovery well and an oil recovery pump thereof, has high blockage removal speed, is neutral and is free of corrosion; the waste liquid for blockage removal does not need to be discharged onto the ground to be subjected to sewage treatment, the blockage removal time does not exceed 24 hours, and the effect of safe and corrosion-free blockage removal is achieved.

A porous scaffold material for tissue engineering is the composition of a polylactic acid type polymer, such as poly-L-lactic acid (PLLA), poly-D, L-lactic acid (PDLLA) and poly-L-lactic acid / hydroxyacetic acid copolymer (PLGA), and a modified nano-class hydroxyapatite (NHA). It is prepared by the thermal phase separation technique.

The invention provides a PLGA (polylactic acid-hydroxyacetic acid) nano-drug carrier which is composed of PLGA nano microsphere kernel and an anillic aldehyde crosslinked chitosan housing. A preparation method of the polylactic acid-hydroxyacetic acid copolymer nano-drug carrier is as follows: dispersing a PLGA organic phase which takes dichloromethane and alcohol as a mixed solvent in a water phase to prepare PLGA microspheres by taking PVA (polyvinyl acetate) as an emulsifier by virtue of an one-off emulsion process; then, adding the PLGA microspheres into chitosan liquor, so that the chitosan is adsorbed on the surfaces of the PLGA microspheres, and then adding the chitosan on the surfaces of anillic aldehyde crosslinked PLGA microspheres. The product has a certain pH environmental responsiveness, can realize controlled release of the drug according to in-vivo pH environmental changes, is high in stability, strong in up-taking capacity for microsphere-coated medicaments by the cells, and has very good application prospect in the drug carrier for treating tumors.

The invention discloses a water-based cleaning agent for an aluminum alloy part. The cleaning agent comprises components in percentage by weight as follows: 2%-10% of AEC (alcohol ether carboxylate), 2%-10% of poly-carboxylate, 5%-20% of an alcohol ether surfactant, 5%-10% of oleamide, 1%-2.5% of diethanol amine, 1%-2.5% of triethanolamine, 0.5%-2% of benzoate, 0.5%-4% of hydroxyacetic acid salt, 1.5%-4% of carbonate, 0.5%-3% of borax, 0.1%-0.6% of sodium hydroxide, 2%-10% of alcohol and the balance of deionized water. The water-based cleaning agent can guarantee the machining precision of an aluminum alloy and is environment-friendly, fast, safe, non-ignitable, non-explosive, simple to operate, low in cost, non-toxic, free from harm to a human body, convenient and safe to use and energy-saving, the cleaning speed is high, the surface quality is good, and a cleaned aluminum alloy can be electroplated later.

The invention discloses skin filler used for injection and a preparing method and application thereof.The skin filler used for injection is composed of sodium carboxymethylcellulose, mannitol and hydrophilic modified polylactic acid microspheres loading an antioxidant factor.Sodium carboxymethylcellulose, mannitol and hydrophilic modified polylactic acid microspheres loading the antioxidant factor are adopted to form the skin filler used for injection, wherein a polyethylene glycol-polylactic acid-hydroxyacetic acid segmented copolymer is adopted as a raw material of the hydrophilic modified polylactic acid microspheres loading the antioxidant factor, the material is good in biocompatibility and moderate in degradation time, and no residue exists in the human body; the preparing method of the skin filler used for injection is easy to operate and facilitates industrial production, activity of the antioxidant factor can be reserved by the process, and by the adoption of the freeze-drying process, the porous microspheres which are high in dissolution speed, uniform in morphology, high in encapsulation efficiency and stable in slow release can be prepared and used for meeting structural design requirements and clinical needs.

The invention discloses a high tensile degradable strontium phosphate calcium composite bone cement for repairing or intensifying fixation of human body holding bone defect and preparation method thereof. The solid material of bone cement is mixed powder of Ca4(PO4)2O ceramic with high crystallinity, SrHPO4, CaHPO4, curing liquid is thin phosphoric acid water solution, additive plasticizing unit is biocompatibility degradable macomolecule fiber with high tensile strength, selecting from lactic acid - hydroxyacetic acid copolymer fibre, polylatic acid fiber or polyglycolic acid fiber or other absorbable surgical suture, the enhancing unit is Ca4(PO4)2O residual ceramic particles after curing reaction. The preparation method coalesces kinds of techniques of ceramic particles in-situ reinforcing, initial plasticizing and later stage degradation of degradable fiber, Sr modification to get a novel high tensile degradable strontium phosphate calcium composite bone cement in like physiologic environment. The material has good biocompatibility, bioactivity, bone conductivity and degradation property.

The invention provides the usage of using the benzoic acid stannous as catalyst. The invention solves the problem that polymerization rate of current catalyst in lactic acid and glycolic acid is slow. The benzoic acid stannous is the catalyst used for preparing low-molecular polymer lactic acid with lactic acid dewatering; benzoic acid stannous is the catalyst used for preparing lactide with low-molecular polymer lactic acid cracking; benzoic acid stannous is the catalyst used for preparing polylactic acid with lactide polymerizing; benzoic acid stannous is the catalyst used for preparing low-molecular polymer glycolic acid with glycolic acid dewatering; benzoic acid stannous is the catalyst used for preparing glycolide with low-molecular polymer glycolic acid cracking; benzoic acid stannous is the catalyst used for preparing poly-glycollide with glycolide polymerizing. The benzoic acid stannous is the catalyst used for polymerizing glycolide, lactide and epsilon-caprolactone. Using the benzoic acid stannous is low content, high productivity, high product purity, low temperature and good repeatability.

The invention relates to aripiprazole sustained-release microspheres and a preparation method thereof. The sustained-release microspheres include aripiprazole and a bio-degradable pharmaceutical high-molecular material PLGA, wherein the ratio of lactic acid to hydroxyacetic acid in the PLGA is 75:50-25:50. The PLGA is 25000-35000 Dolton in molecular weight. The addition weight ratio of the aripiprazole to the PLGA is 1:1-20. The aripiprazole accounts for 3.01-21.09% of total weight of the microsphere. The aripiprazole sustained-release microspheres have high drug embedding rate, is high in drug loading capacity, is smooth and round in surface and can release more than 90% of the drug in 30 days.

The invention relates to an adjuvant for coal washing and desulfurizing. The adjuvant is prepared from the following raw materials in parts by weight: 20-25 parts of sodium hypochlorite NaClO, 12-15 parts of ammonium persulfate (NH4)S2O8, 8-12 parts of sodium glycollate HOCH2COONa, 6-10 parts of sodium acetate CH3COONa, 7-12 parts of potassium citrate K3C6H5O7H2O, 5-9 parts of sodium gluconate, 5-9 parts of edetic acid, 7-12 parts of potassium permanganate KMnO4, 25-32 parts of methanol CH3OH, 22-30 parts of triethanolamine (HOCH2CH2)3N, 12-16 parts of sodium dichromate Na2Cr2O7, 3-5 parts of polyaluminum ferric chloride PAFC,1-2 parts of urea CON2H4, 1-2 parts of polyacrylamide PAM, 0.5-0.8 part of sodium dodecyl benzene sulfonate C18H29NaO3S, 0.2-0.4 part of dispersing agent JFC and 100-120 parts of water. The adjuvant disclosed by the invention is simple to use, stable in performance and free of large investment and transformation equipment; the removal rate of inorganic sulfur and organic sulfur is more than 70 percent; and the removal rate of nitric oxides is more than 70 percent.

A slowly-releasing nano-particle of curcumin is prepared from the nano-particle of curcumin and the degradable polymer chosen from polylactic acid and the polylactic acid-hydroxyacetic acid copolymer by emulsion-solvent diffusion technique. It has high water dispersity and long releasing time (more than 2 weeks).

A mineralized porous silk protein/high-molecular material composition with high biocompatibility and biodegradability for repairing bone is prepared through preparing the aqueous solution of deglued silk protein, dropping the Ca ions contained solution in it while stirring, slowly dropping PO4 ions contained solution, regulating pH value, stirring, laying aside, centrifugal separation and washing several times, vacuum drying, grinding, and mixing with the biocompatible high-molecular material chosen from polylactic acid, copolymer of lactic acid and hydroxy acetic acid, sodium alginate, etc.

The invention belongs to the technical field of chemical cleaning of metal surfaces, and particularly relates to a metal surface cleaning anti-scaling agent containing compound acid. The agent comprises two or more components in parts by weight as follows: 70-98 parts of sulfamic acid, 0.05-20 parts of glycolic acid, 0.05-20 parts of tartaric acid, 0.05-20 parts of lactic acid, 0.05-20 parts of gluconic acid, 0.05-20 parts of salicylic acid, 1.5-1.8 parts of a sulfamic acid corrosion inhibitor and 0.2-0.45 part of a surfactant. The agent utilizes sulfamic acid as the main pickling potion, the material status is solid, therefore the transportation is convenient, the cost is low, the pickling temperature is low, the implementation is facilitated, and time, labor and energy are saved. During water washing after pickling, the temperature difference born by a water wall can be reduced greatly under the condition of insufficient heat source capacity, and the protection of the water wall is facilitated. The agent is further provided with characteristics of simple postprocessing, low cleaning cost, and the like, can be applied to chemical surface cleaning of various metal materials such as carbon steel, stainless steel, alloy steel and the like, and can be widely applied to chemical cleaning of various large-capacity boilers and heat exchangers.

The invention provides a nanofiber membrane and a preparation method and application thereof. The nanofiber membrane is formed by fibers of a core-shell structure and is characterized in that the core is formed by mixed fibers mixed by polylactic acid-hydroxyacetic acid and polycaprolactone, the shell is formed by fibers formed by gelatin crosslinking with genipin, and the core is loaded with chemical therapy medicine. The nanofiber membrane prepared by the coaxial electrospinning technology has an in-situ anti-cancer function and is implantable, good in biocompatibility, free of cytotoxicity to normal cells and good in curative effect on tumor. The preparation method is simple, mild in condition, low in cost and easy to popularize and apply.

The invention discloses a preparation method of high-purity glycolic acid crystals. The preparation method comprises the following steps of: (1) taking a 70% or below glycolic acid aqueous solution as a raw material, and firstly concentrating the glycolic acid aqueous solution to be of 70% or above under a low temperature vacuum condition; (2) slowly cooling and crystallizing the concentrated glycolic acid aqueous solution, and ensuring that crystal crude products are obtained through timely filtration at a low temperature; and (3) repeatedly washing the crystal crude products by an appropriate organic solvent, removing a small amount of glycolic acid low polymers from the crystals, and then drying the crystals at the low temperature to obtain the high-purity crystals. According to the preparation method, various traditional glycolic acid technical aqueous solution can be processed, the concentration requirement for the glycolic acid aqueous solution is low, the solution of below 70% can be above 70% by concentration so that the crystallization is facilitated; the crystals have high purity after being processed, are higher in yield and convenient for increasing the additional value of products; and the technology is simple and free of pollution.

The invention relates to a cleaning solution for metal surface oil and rust removal and relates to the technical field of metal surface treatment. The cleaning solution is prepared from the following components in parts by weight: 75-85 parts of deionized water, 4-6 parts of sophocarpidine, 4-6 parts of alkaloid of tea leaves, 4-6 parts of tartaric acid, 4-6 parts of hydroxyacetic acid, 4-6 parts of urea, 4-6 parts of hydroxypropyl-beta-cyclodextrin, 4-6 parts of octadecanol, 4-6 parts of graphene and 4-6 parts of a modifier. The cleaning solution is prepared by the following steps: feeding the components together into a reaction container; and stirring for 30 minutes at 80-90 DEG C. The cleaning solution provided by the invention is low in cost, simple in preparation method and safe and environment-friendly and has a good cleaning effect to metal pieces with much greasy dirt and rusts, and the product quality can be guaranteed.

The invention discloses galanthamine microspheres which contain 5-40wt% of basic group of galanthamine and 60-95wt % of polylactic acid/hydroxyacetic acid copolymer. The invention also provides a galanthamine long-acting release injectable microsphere composite which comprises the following components by weight percent: 60-90% of galanthamine microspheres, 5-25% of frozen dry proppant, 0.5-5% of suspending agent, 0.5-5% of wetting agent and 1-25% of osmotic pressure regulator. The invention combines the vibration nozzle method with the emulsion process (O/W)-solvent evaporation method so that the method has the advantage that the droplet-generating speed is fast, the efficiency is high, the containers used in preparation are easy to use in the aseptic operation, the production process can be carried out continuously, the technology is applicable to scale-up application, etc.

A doxorubicin microball used for arterial embolism, intratumor injection, tumor-side injection, or lumbar injection is prepared from polylactic acid-hydroxyacetic acid copolymer. Its preparing process is also disclosed.

The invention belongs to the field of preparation of targeted therapeutic microspheres of slow release formulation and in particular relates to a preparation method of taxol-loading polylactic acid-hydroxyacetic acid (PLGA) microspheres. The preparation method comprises the following steps: dissolving a polylactic acid-hydroxyacetic acid copolymer in an organic solvent, and adding a taxol drug, wherein the polymer and the taxol drug are uniformly dissolved to obtain an organic phase; dropwise adding the organic phase into a fresh polyvinyl alcohol aqueous solution and curing and forming microspheres; and performing centrifugal separation on the cured drug-loading microspheres to obtain the uniformly dispersed taxol-loading polylactic acid-hydroxyacetic acid (PLGA) microspheres. The taxol-loading targeted therapeutic PLGA microspheres prepared by the preparation method have an ideal drug loading ratio and encapsulation efficiency while guaranteeing the drug stability of taxol, can reach an effect of slow release, maintain the optimum drug concentration in vivo, prolong the action time of the drug and reduce the side effects brought by burst release of the drug, and have important theoretical value and actual application prospect.

The invention discloses a cell-biological scaffold complex and a 3D printing forming method thereof. The cell-biological scaffold complex comprises a biological scaffold and a cell-biological gel suspension arranged on the biological scaffold, wherein the biological scaffold comprises a one of or a combination of several of a biological macromolecular material, a natural biological material and an inorganic material, the biological macromolecular material comprises one of or a combination of several of calcium phosphate, polycaprolactone, polytetrafluoroethylene and lactic acid-hydroxyacetic acid copolymer, the natural biological material comprises one of or a combination of two of gelatin and sodium alginate, the inorganic material comprises one of or a combination of several of calcium sulfate, boron silicate and nano hydroxylapatite, the cell-biological gel suspension comprises cell and biological gel, and the cell is a bone cell or a corneal stroma. By adopting the cell-biological scaffold complex and the 3D printing forming method, a complexing efficiency of the cell and the biological gel suspension can be increased, the loss or dropping of a great amount of cells is avoided, the preparation process is simple, and the use is convenient.

The invention relates to the technical field of traditional Chinese medicine cosmetics and particularly discloses a method for extracting collagen polypeptide from tortoise shells and an application of the collagen polypeptide in preparation of a sleeping mask. The method comprises the following steps: decocting and extracting the tortoise shells with water, carrying out enzymolysis on the extracted liquid with pepsin and trypsin in sequence to form a collagen and polypeptide composition, and then adding lactic acid, hydroxyacetic acid and various common auxiliary materials to prepare the sleeping mask and various cosmetics which have the functions of removing freckles and moistening skin, whitening skin and resisting wrinkles as well as preserving moisture and nourishing. Compared with the prior art, the sleeping mask is more suitable for consumption needs of consumers and can reflect the efficacies of traditional Chinese medicinal materials well.