53 results about "Hydroxyacetic Acids" patented technology

The invention belongs to the technical field of organic synthesis, and provides a preparation method of a cationic lipid compound, which comprises the following steps: (1) reacting 1, 5-dihalopentane, 2-tert-butyl glycolate and alkali to obtain a product G; (2) hydrolyzing the product G under an acidic condition to obtain a product H; (3) carrying out esterification reaction on the product H, the raw material C, 4-dimethylaminopyridine and a condensing agent in dichloromethane to obtain a product J; and (4) carrying out amination reaction on the product J, the raw material L and alkali in acetonitrile to obtain the cationic lipid compound. Compared with the prior art, the method has the relatively remarkable advantages that when the first part of halogenated long-chain alkyl ester H is synthesized by the method, 1, 5-dihalopentane and 2-tert-butyl glycolate are used as raw materials, the halogenated long-chain alkyl ester J is synthesized by a simple method, the product is obtained at a higher yield in synthesis, and the method is suitable for kilogram-level production. The route synthesis only comprises four steps of chemical reactions, and is suitable for industrial production.

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The invention discloses a lumepirone long-acting microsphere sustained-release preparation without a release stagnation period in an early stage, which comprises a lumepirone active ingredient and a medicinal polymer auxiliary material in a mass ratio of (1: 4)-(1: 1), the medicinal polymer auxiliary material is at least one of glycolide-lactide copolymers with the weight-average molecular weight of 5000-150000 Da, and the molar ratio of lactic acid units to glycolic acid units of the glycolide-lactide copolymers is (50: 50)-(95: 5). The lumepirone long-acting microsphere sustained-release preparation without a release arrest phase in the early stage is obtained by specially limiting drying conditions in liquid and medicinal polymer auxiliary materials, the release of the lumepirone long-acting microsphere sustained-release preparation can be maintained for 2 weeks to 1 month without oral administration of the long-acting sustained-release microspheres of lumepirone capsules, the safety and effectiveness of the medicine are met, and the sustained-release preparation is suitable for clinical application. Meanwhile, the problems of early-stage long-time stagnant release and early-stage burst release of the long-acting microsphere preparation can be solved, the compliance can be effectively improved, convenience is provided for patients to the maximum extent, and the economic cost is reduced.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention discloses a preparation method of a sodium lauryl glycol carboxylate compound, which comprises the following specific steps: adding 1, 2-epoxydodecane and glycolic acid into a first reaction flask containing a solvent, and carrying out heating reaction under the action of a large-steric-hindrance catalyst to obtain lauryl glycol acetic acid; wherein the solvent is cyclohexane, normal hexane or methylbenzene, and the large steric hindrance catalyst is tri (pentafluorophenyl) borane; and S3, adding the lauryl glycol acetic acid prepared in the step S1 into a second reaction flask containing water, and adjusting the pH value of the solution in the second reaction flask to 8.5-11.5 by using a certain amount of sodium hydroxide solution to prepare lauryl glycol sodium carboxylate, namely the target compound. According to the preparation method disclosed by the invention, the single selectivity of the synthesis process is improved, so that the purity and yield of the sodium lauryl glycol carboxylate compound synthesized by the route are greatly improved, and the product becomes better and better in application.

A PLG copolymer material, called a PLG(p) polymer material adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced initial burst effect when introduced into the tissue of a patient in need thereof. A method of preparing the PLG copolymer material is also provided, as are methods of use.

The invention relates to the technical field of modified calcium carbonate, in particular to modified calcium carbonate, which comprises the following structures: an inner core: lithium battery recycled calcium carbonate slag, which comprises 1.2-1.8 wt% of Li2CO3 and 0.5-1.2 wt% of MgCO3; the middle layer is a polydopamine (PDA) coating film, the thickness of the polydopamine (PDA) coating film is 50-80 nm, and the polydopamine (PDA) coating film is used for providing active amino (-NH2); the shell is a fluorine-containing silane and polylactic acid-glycolic acid copolymer (PLGA) composite layer, the grafting rate is larger than or equal to 90%, and the molar ratio of lactic acid to glycolic acid of PLGA is 75: 25. Quantized data of performance improvement and dispersibility are as follows: the oil absorption value is 18 ml / 100 g (compared with 28-32 ml / 100 g in the prior art), and the bulk density is 0.25 g / cm < 3 > (loose agglomeration). Functions are as follows: flame retardance: the oxygen index (LOI) reaches 34.5% (no flame retardance exists in the prior art); the antibacterial property is that the Escherichia coli inhibition rate is 99.2% (ASTM E2149 standard), and the environmental protection property is that 2.8 tons of limestone can be reduced for each ton of products, and 1.2 tons of CO2 emission can be reduced.

The present application relates to the technical field of purification, and discloses a dehydrated fiber membrane and a preparation method and application thereof.A dehydrated fiber membrane, wherein the dehydrated fiber membrane comprises a hollow fiber membrane base, a first silane membrane, a first hydrophilic membrane and a first modified membrane are coated on the inner surface of the hollow fiber membrane base from inside to outside, and a second silane membrane, a second hydrophilic membrane and a second modified membrane are coated on the outer surface of the hollow fiber membrane base from inside to outside; the first hydrophilic membrane and the second hydrophilic membrane each independently contain an amide group; the first modified membrane contains a sulfonamide group; and the second modified membrane contains a pyrrole group, a sulfhydryl group and / or a sulfide group.The dehydrated fiber membrane can effectively reduce the content of oligomers in the hydroxyacetic acid dehydration process.

The application provides a bathroom secondary cleaning agent and relates to the technical field of sanitary products. The bathroom secondary cleaning agent comprises A material and B material. The A material comprises rose-sour powder; the B material comprises, in percentage by mass, 0.1-5% of a hydrophilic group modified polymer, 1-5% of a modified acrylamide polymer, 0.1-2% of glycolic acid, 0.5-3% of a Zanthoxylum bungeanum leaf extract, 0.5-4% of a propoxy compound and the balance of water. The rose-sour extract contains various organic acids, and the organic acids cooperate with the modified acrylamide polymer, the glycolic acid and the propoxy compound in the liquid reagent, so that various components such as scale, oil stains, rust stains and soap stains in the bathroom can be effectively removed, and cleaning is easier. In addition, the cleaning agent is added with the Zanthoxylum bungeanum leaf extract, and has the functions of sterilization and deodorization.

The invention belongs to the field of high polymer materials, particularly relates to a novel high polymer alloy material and a master batch prepared from the novel high polymer alloy material, and further relates to application of the high polymer alloy material and the master batch. The polymer alloy material is a PETX / PBAT blended composition, and PETX is copolyester of ethylene glycol terephthalate and glycolic acid and / or lactic acid. According to the polymer alloy material and the master batch, excellent balance of rigidity and toughness can be achieved, the raw material cost and the process complexity are reduced, the soil moisture preservation performance of the material is improved, and meanwhile the application direction of PET plastic recycling is effectively expanded.

The invention provides a preparation method for coproduction of hydroxyethyl piperazine and triethylene diamine, which comprises the following steps: by taking dimethyl oxalate directly prepared from coal as a key raw material, carrying out catalytic hydrogenation reduction reaction on the dimethyl oxalate to obtain alpha-methyl glycolate; then the alpha-methyl glycolate and piperazine are subjected to a nucleophilic acyl substitution reaction, and an intermediate product 2-hydroxy-1-(piperazine-1-yl) ethanone is generated; and finally, carrying out hydrogenation reduction on the intermediate product under the action of a catalyst to synchronously obtain target products, namely hydroxyethyl piperazine and triethylene diamine. According to the method, double products of hydroxyethyl piperazine (medicine and dye intermediates) and triethylene diamine (a polyurethane catalyst and a rubber accelerator) are synchronously generated, the total yield of hydroxyethyl piperazine reaches 72% or above, the yield of triethylene diamine reaches 70% or above, the two products are high-added-value fine chemical products, and compared with a single product route, the method has the advantages that the yield is high, and the cost is low. The economic benefit of unit raw materials can be greatly improved, and the resource utilization rate is maximized. The invention belongs to the technical field of organic synthesis.

RENAISSANCE HSP3 - a unique complex of active ingredients providing hydration, regeneration, and skin protection. To achieve the best results in improving the appearance and condition of the skin, an active complex of multi-directional ingredients was designed and created. H - Hyaluronic Acid INCI: Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid P - Peptide INCI: Acetyl Hexapeptide-8 S - Stem Cells INCI: Haberlea Rhodopensis Leaf Extract The combination of the well-researched ingredients described above results in a complex that provides: - Hydration - Anti-wrinkle - Regenerative - Protective - Antioxidant effects The use of this complex in cosmetic products for facial and body care will result in safe and highly effective products.

The invention provides a resourceful treatment method for glycolic acid wastewater, and belongs to the technical field of wastewater resourceful utilization. The method comprises the following steps: carrying out reduced pressure distillation on glycolic acid wastewater, and carrying out solid-liquid separation to obtain a first concentrated solution; adding an organic solvent into the first concentrated solution, carrying out a reflux dehydration reaction, and after the reaction is completed, cooling to room temperature to obtain a second concentrated solution; performing solid-liquid separation on the second concentrated solution to obtain solid salt and organic phase filtrate; and distilling the organic phase filtrate, separating and recovering the organic solvent, and returning to the reflux dehydration step for recycling, thereby obtaining the distillation residue, namely the glycolic acid solution. The method can effectively separate solid salt and glycolic acid, turns waste into wealth, realizes resource utilization of wastewater, and has remarkable environmental, economic and social benefits.

This invention provides a copper etching solution, its preparation method, etching method, and application. The copper etching solution comprises 1-30 parts cerium ammonium sulfate, 0-20 parts inorganic acid, 0-20 parts organic acid, and 0-90 parts water. The inorganic acid includes one or more of sulfuric acid, phosphoric acid, hypochlorous acid, chloric acid, boric acid, carbonic acid, nitric acid, nitrous acid, and hydrochloric acid. The organic acid includes one or more of citric acid, acetic acid, tartaric acid, malic acid, formic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, glycolic acid, acrylic acid, methacrylic acid, lactic acid, gluconic acid, maleic acid, benzoic acid, and salicylic acid. The copper etching solution of this invention exhibits good etching properties for copper and minimal damage to nickel-chromium alloys.

This invention relates to the field of coating technology, specifically to a printing coating for colored paper and its preparation method. In the preparation process, this invention incorporates dithiol dihydroxyacetic acid to increase the crosslinking points of the system, and trimethylolpropane tris(2-methyl-1-azacyclopropane propionate) containing an unstable aziridine three-membered ring to improve the degree of crosslinking. It also introduces isoborneol methacrylate to reduce internal stress, effectively balancing the crosslinking density and volume shrinkage of the system, resulting in a coating with excellent adhesion. Furthermore, this invention adds the bifunctional monomer 1,6-hexanediol diacrylate to make the network structure more uniform and provide anti-photooxidation properties, making the system less prone to oxidative discoloration. The addition of tripropylene glycol diacrylate reduces the risk of yellowing caused by small molecule migration. Therefore, the coating obtained in this way has significant anti-yellowing effects, preventing color distortion of colored paper and maintaining the appearance stability of the colored paper.

The invention discloses a continuous synthesis method and device of MSH.The continuous synthesis method of MSH comprises the steps that 2, 4, 6-trimethylbenzenesulfonyl chloride and an acid binding agent are dissolved in a first solvent to form a first solution, N-hydroxy-acetic acid imino ethyl ester is dissolved in the first solvent to form a second solution, and the second solution is dissolved in a third solvent to form a second solution; respectively pumping the first solution and the second solution into a first reaction container for reaction to obtain a first effluent; the first effluent, perchloric acid and a second solvent respectively flow into a second reaction container for reaction, and second effluent containing MSH is obtained. According to the present invention, the flow chemical design idea is adopted to continuously synthesize MSH, the stability of the raw material is good, the intermediate high-energy product and the high-energy end product can be rapidly utilized, and the accumulation and the long-time retention are effectively avoided so as to effectively avoid the decomposition and reduce the safety risk; the device disclosed by the invention is simple in structure, suitable for being matched with a production line of MSH derivative products, and convenient for synthesizing MSH at present.

A nanofiber matrix material for application to a wound, comprising at least one layer of nanofiber. The nanofiber comprises poly-p-dioxanone (PDO), a surfactant, and one or more of the following polymers: poly(lactic-co-glycolic acid) (PLGA), polyglycolic acid (PGA), poly(glycolide-co-caprolactone) (PGCL), poly(lactide-co-caprolactone) (PLCL), polycaprolactone (PCL), polylactic acid (PLA), and poly(4-hydroxybutyric acid) (P4HB). The nanofiber matrix material is easy to prepare and maintains high thermal stability during preparation and use. Moreover, the material is highly hydrophilic; the material can rapidly draw exudate from a wound and help the wound heal faster.

Method for producing a sterile oxybutynin-containing composition in a preferably ready-to-use piston syringe, in particular a disposable piston syringe, and / or for producing a preferably ready-to-use, sterile piston syringe filled with an oxybutynin-containing composition, in particular a disposable piston syringe, wherein the piston syringe has a syringe body on one side and a syringe piston with a piston stopper on the other, wherein the syringe body is made of polypropylene, and wherein the final oxybutynin-containing composition obtained after completion of the process, in particular after process step b), is formed as a sterile aqueous composition, in particular a terminally sterilized composition, and has the following specification requirements (i) and (ii) and / or (iii), preferably (i), (ii) and (iii): (i) specified concentration of oxybutynin, preferably in the form of the hydrochloride, with a specified deviation of not more than ± 5%, based on the concentration of oxybutynin, (ii) specified specification pH value with a specified deviation of not more than ± 0.5 pH units, (iii) specified maximum quantity of oxybutynin degradation product(s), in particular reactively generated oxybutynin degradation product(s), preferably hydrolytically and / or oxidatively generated oxybutynin degradation product(s), preferably phenylcyclohexylhydroxyacetic acid; the procedure includes the following steps: a) Providing an oxybutynin-containing starting composition in the piston syringe and / or filling the piston syringe with an oxybutynin-containing starting composition and subsequently b) Heat sterilization, in particular steam sterilization, preferably steam sterilization, preferably terminal sterilization, of the oxybutynin-containing starting composition in the syringe and / or the syringe filled with the oxybutynin-containing starting composition to obtain the sterile oxybutynin-containing final composition in the preferably ready-to-use syringe and / or to obtain the preferably ready-to-use, sterile syringe filled with the oxybutynin-containing composition, wherein the migration and / or incorporation of the oxybutynin into the syringe body and / or the plunger stopper occurring in the process, in particular in process step b), and / or the degradation of the oxybutynin occurring in the process, in particular in process step b), in particular the reactive degradation of the oxybutynin, preferably the hydrolytically and / or oxidatively induced degradation, preferably the degradation to phenylcyclohexylhydroxyacetic acid, is controlled and / or compensated in such a manner and with the proviso that that the sterile oxybutynin-containing final composition obtained after carrying out process step b) meets the previously mentioned specification requirements (i) and (ii) and / or (iii), preferably (i), (ii) and (iii), and that the sterile oxybutynin-containing final composition is obtained in the preferably ready-to-use piston syringe or the preferably ready-to-use, sterile piston syringe filled with the oxybutynin-containing final composition, wherein the migration and / or incorporation of the oxybutynin into the syringe body and / or the plunger stopper occurring in the process, in particular in process step b), and / or the degradation occurring in the process, in particular in process step b), in particular the reactive degradation of the oxybutynin, preferably the hydrolytically and / or oxidatively caused degradation of the oxybutynin, preferably the degradation to phenylcyclohexylhydroxyacetic acid, is controlled and / or monitored, in particular prevented and / or minimized and / or compensated for, by at least one of the following measures and / or steps (1), (2), (3) and / or (4): (1) Adjustment and / or use of an increased concentration and / or amount of oxybutynin, preferably in the form of the hydrochloride, in the initial composition compared to the specified concentration and / or amount of oxybutynin, preferably in the form of the hydrochloride; (2) Adjustment of the pH value of the initial composition to a value that differs from the specified pH value, in particular an increased pH value; (3) Setting and / or selecting the sterilization conditions, in particular selected from the group consisting of sterilization type, sterilization duration, sterilization temperature, sterilization pressure, sterilization atmosphere and combinations thereof, preferably setting and / or selecting the F0 value of the sterilization; (4) Equipment and / or treatment, in particular coating, of the syringe body, preferably the inner wall of the syringe body, and / or the plunger stopper with at least one migration- and / or degradation-reducing agent.

The invention relates to a poly-L-lactic acid microsphere used for a drug delivery system and having a controllable degradation rate and a preparation method and application thereof.The preparation method comprises the steps that an oil-phase organic solution is added into an emulsifier aqueous solution through an SPG film to be stirred for a reaction, and a poly-L-lactic acid microsphere crude product is obtained; sequentially mixing and reacting the L-polylactic acid microsphere crude product with a sodium hydroxide solution and a polylysine solution, washing and freeze-drying to obtain L-polylactic acid microspheres; a solute in the oil-phase organic solution comprises poly-L-lactic acid and a lactic acid-glycolic acid-polyvinyl alcohol block copolymer. The poly-L-lactic acid microsphere material obtained through a specific preparation process has good stability and biocompatibility, is controllable in degradation rate, and is suitable for preparing a drug delivery system, so that the drug curative effect is improved, and the drug administration frequency is reduced.

The application discloses a kind of for nuclear power plant two loop systems chemical cleaning agent and cleaning method, belong to nuclear power plant equipment chemical cleaning technical field.The cleaning agent is by cleaning main agent ethylenediaminetetraacetic acid, cleaning auxiliary agent (citric acid and / or glycollic acid), corrosion inhibitor N-108, pH regulator ammonia water, reducing agent (hydrazine hydrate or D-sodium isoascorbate), organic silicon defoaming agent and solvent (deionized water or desalted water) compound is formed.The cleaning agent cleaning stage is carried out at pH 5.5~6.5, temperature 110~130 DEG C;Passivation stage is completed by supplementing ammonia water at pH 8.5~9.5, temperature 80~95 DEG C.The cleaning agent of the application has high dissolution rate (up to 96.5%) to common scale type such as Fe3O4, has very low corrosion rate (<0.005 g / m 2 ·h) to austenitic stainless steel and nickel-based alloy, and seamless conversion of cleaning and passivation can be realized by pH adjustment, the operation process is simple, the waste liquid amount is less, the environmental protection is good, and the safety, efficient operation of nuclear power unit two loop system can be effectively guaranteed.

The invention discloses a gas well potential tapping and yield increasing composite technology, and relates to the technical field of petroleum and natural gas development, the gas well potential tapping and yield increasing composite technology comprises the following three steps: S1, plugging removal liquid (18-22% of composite chelating acid, 0.6-1.0% of a nanometer surfactant, 0.4-0.7% of a biological enzyme preparation and the balance of formation water, and the chelating acid is prepared from glycolic acid, EDTA disodium and ammonium fluoride according to the ratio of 18-22: 6-8: 4-7); s2, performing 3-5 stages of fracturing circulation, and injecting prepad fluid, sand-carrying fluid and a temporary plugging agent at each stage; and S3, supercritical gas is injected step by step, the initial pressure is 0.65-0.75 times of formation pressure, the final pressure is 1.3-1.45 times of formation pressure, and the pressure is increased by 0.02-0.03 MPa / min. According to the invention, pre-blocking removal and multi-stage temporary blocking fracturing are cooperated, a complex fracture net is made by means of a compound agent, pulse blocking removal and improvement of liquid spreading, and a bi-component temporary blocking agent and modified ceramsite; a desorption activation program is combined with controllable gradient supercritical gas injection, mixed gas activates adsorption gas, supercritical gas channeling prevention is controlled, real-time monitoring is carried out, traditional pain spots are broken, the recovery rate of residual gas is increased, and the stable production period of a gas well is prolonged.

The application relates to a modified polylactic acid-glycolic acid copolymer and a preparation method and application thereof, and the preparation method comprises the following steps: mixing, reacting glycolic acid monomers, lactic acid monomers, a functional branched agent and a catalyst to prepare a PLGA polymer melt, wherein the functional branched agent comprises one or more of the following substances: a hyperbranched polyhydroxy polymer, a polyamine compound and a hyperbranched polycarboxyl polymer; after the PLGA polymer melt is cooled, crushing treatment is carried out to obtain crushed materials; the crushed materials, a chain extender and a functional additive are melt blended, and a modified polylactic acid-glycolic acid copolymer is obtained after a chain extension reaction. Compared with the prior art, the preparation method has the advantages of easy availability of raw materials and environmental friendliness, and is easy to be industrialized, the molecular weight and strength of the prepared modified polylactic acid-glycolic acid copolymer are high, and the modified polylactic acid-glycolic acid copolymer has good mechanical properties, heat resistance and biological full-degradation performance.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses curcumin-cyclodextrin-polylactic acid-glycolic acid copolymer composite nanoparticles as well as a preparation method and application thereof. According to the nanoparticles, curcumin is used as an active component, and cyclodextrin and a polylactic acid-glycolic acid copolymer are used as a carrier of a nano skeleton. The core of the preparation method is mainly as follows: firstly, curcumin and cyclodextrin form an inclusion compound in an organic solvent, then the inclusion compound is entrapped in a nanoparticle skeleton formed by a polylactic acid-glycolic acid copolymer, and finally, a nanoparticle colloidal solution is formed. The prepared composite nanoparticles are small in particle size, uniform in distribution, high in encapsulation efficiency and good in stability, the solubility, bioavailability and anti-tumor activity of curcumin can be remarkably improved, and the composite nanoparticles have wide application prospects in breast cancer treatment drugs.

The application discloses a continuous production process of acetoxy acetyl chloride, which uses sodium glycolate acetic acid solution and acetyl chloride as raw materials, and realizes continuous esterification through three-stage series connection of esterification kettles, degassing and desalting and solvent recovery, continuous acyl chloride through a static mixer coupled with a tubular reactor, and single-kettle high-vacuum two-stage rectification to obtain high-purity products. The application realizes closed continuous production in the whole process, improves production efficiency compared with batch process, controls stable and controllable reaction conditions, suppresses side reactions, and has product purity greater than or equal to 99.7%, yield greater than or equal to 96.2%, and acetyl chloride residue less than or equal to 0.1%. The application realizes full recovery and reuse of acetyl chloride and acetic acid, does not generate aluminum-containing hazardous waste, significantly reduces energy consumption and cost, has high automation degree and high safety, and is suitable for stable industrial production.

The invention discloses a multifunctional rust-removing and rust-preventing lubricating cleaning fluid for ship pipelines and a preparation method of the multifunctional rust-removing and rust-preventing lubricating cleaning fluid, and relates to the technical field of rust-removing and rust-preventing lubricating cleaning fluid for ship pipelines and preparation of the multifunctional rust-removing and rust-preventing lubricating cleaning fluid. Comprising the following components: 20-30 parts of an organic acid complexing agent, 8-15 parts of a low-foam surfactant, 5-12 parts of a metal corrosion inhibitor, 3-8 parts of a lubricating film-forming agent, 4-9 parts of a reducing agent and 40-60 parts of water. Wherein the organic acid complexing agent is formed by compounding citric acid and glycolic acid according to the mass ratio of 1: 0.51: 1.5; the low-foam surfactant comprises suberic acid dimonoethanolamide polyoxyethylene ether and alkyl polyoxyethylene ether phosphate in a mass ratio of 1: 11: 2, the whole formula realizes stable integration through component optimization and a mild preparation process, the functions of rust removal, rust prevention, lubrication and low-foam cleaning are synchronously completed, the maintenance process is greatly simplified, the downtime is shortened, and the production cost is reduced. The comprehensive cost is reduced.

The invention relates to the field of electroplating of backboard connectors, and particularly discloses an electroplating method of a high-speed line backboard connector, which comprises the following steps: S1, washing the surface of a copper substrate to obtain a pretreated substrate; s2, electroplating a nickel layer on the surface of the pretreated base material, and cleaning to obtain a semi-finished product; s3, after the surface of the semi-finished product is electroplated with a gold layer, a finished product connector is obtained after hole sealing, water washing and drying; an electroplating solution of the nickel electroplating layer comprises the following raw materials in parts by weight: 280-320 g / L of nickel aminosulfonate, 100-140 g / L of polyethylene glycol compounded nickel aminosulfonate, 50-60 g / L of nickel sulfate, 30-40 g / L of boric acid, 120-180 g / L of pyridinium hydroxy propyl sulfobetaine, 10-25 g / L of triethanolamine compounded glycolic acid, 5-10 g / L of a brightener and the balance of pure water which is supplemented to 1 L; the coating has the advantages of uniform coating, good binding force between the coating and a base material and good conductivity.

The present application relates to the technical field of glycolic acid solution concentration, and discloses a reboiler and a preparation method and application thereof.A reboiler comprises a reboiler base body and a silane layer, a first modified layer and a second modified layer which are coated on the outer surface of the reboiler base body from inside to outside; the first modified layer contains an amide group, and the second modified layer contains a pyrrole group, a mercapto group and / or a sulfide.The reboiler provided by the present application can effectively reduce the oligomer content in the target product after modification.

The invention discloses an alkalescent zinc-based flow battery negative electrode electrolyte and a preparation method thereof. The alkalescent zinc-based flow battery negative electrode electrolyte comprises zinc salt, deionized water and a complexing agent, wherein the complexing agent is one or more of 2-phosphonobutane-1, 2, 4-tricarboxylic acid, triethylene tetramine, glycine, diethyl ethylenediamine, lysine, N-(phosphoryl methyl) iminodiacetic acid, iminodiacetic acid, hydroxyethylidene diphosphoric acid, iminodisuccinic acid, N-(phosphoryl methyl) glycine, glycolic acid, nitrilotrimethylene phosphoric acid and alendronic acid. According to the invention, the problems that the zinc-based flow battery negative electrode is easy to form dendritic crystals and delay hydrogen evolution and other side reactions during zinc deposition are solved, the reversibility of the zinc negative electrode in the cycle process is improved, the cycle life of the alkalescent zinc-based flow battery is prolonged, and meanwhile, the total battery voltage can also be improved.

The embodiment of the invention provides a method for detecting the content of glycolic acid in cocamidopropyl betaine and application thereof. The detection method comprises the following steps: preparing glycolic acid standard solutions with different concentrations by adopting an anhydrous solvent; obtaining standard samples with different concentrations; performing high performance liquid chromatography ultraviolet detection on the standard samples with different concentrations to obtain the glycolic acid peak areas of the standard samples with different concentrations, and obtaining a linear equation of the glycolic acid concentration x and the glycolic acid peak area y according to the standard samples with different concentrations and the corresponding peak areas; obtaining a to-be-detected sample; performing high performance liquid chromatography ultraviolet detection on the to-be-detected sample to obtain the peak area of glycolic acid in the to-be-detected sample; and substituting the peak area of the glycolic acid in the sample to be detected into the linear equation, and calculating to obtain the content of the glycolic acid in the sample to be detected. According to the embodiment of the invention, the problem of impurity interference in the existing glycolic acid detection method is solved, and the accuracy and precision of the detection result can be effectively improved.

This invention discloses a microemulsion-type stainless steel cleaning agent and its preparation method, relating to the fields of metal surface treatment and fine chemical technology. The cleaning agent is prepared from the following raw materials in weight percentages: 5%~10% complex organic acid, 1%~3% gluconolactone, 3%~6% microemulsifying surfactant, 2%~4% solubilizer, 0.5%~1.5% corrosion inhibitor, 1%~2.5% penetrant, 1%~3% chelating-reducing bifunctional auxiliaries, 0.3%~1.5% pH adjuster, with the balance being deionized water. The complex organic acid is a mixture of citric acid and tartaric acid, malic acid, or glycolic acid; the chelating-reducing bifunctional auxiliaries are ascorbic acid or isoascorbic acid. This cleaning agent is a bicontinuous medium-phase microemulsion with a pH of 6.5~7.5. Through synergistic formulation and a unique preparation process, the cleaning agent of this invention achieves gentle, efficient, and environmentally friendly cleaning on stainless steel surfaces, effectively removing oil, oxides, and scale without corrosion or residue.