The invention discloses an Internet + industrial 4.0 intelligent manufacturing management method and a system. The Internet + industrial 4.0 intelligent manufacturing management method and the system are used to provide a comprehensive information resource service for system exploitation, testing and operation deployment. The method and system are characterized in that the Internet + industrial 4.0 intelligent manufacturing management method and the system comprise five layers of service frameworks, two safety systems and intelligent building management; the five layers of frameworks are a hardware platform layer, a software platform layer, a production manufacturing execution layer, a service operation management layer and a strategy management layer from bottom to top respectively; through the intelligent building management and a series of guarantee support auxiliary of the two systems of an operation maintenance and IT management system and safety guarantee, sensors which are located everywhere, an embedded terminal system, an intelligent control system and communication facilities form one intelligent network through a CPS. People and people, people and machine, machine and machine, and server and server can be interconnected so that transverse, vertical and end-to-end high integration is realized. A production network is constructed. Perfect fusion of virtual and real worlds is achieved and an industrial 4.0 mode of information physics fusion system construction and application is constructed.