Carboxymethyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

Abstract

The invention discloses a self-crosslinking antibacterial hydrogel material containing carboxymethyl chitosan/oxidized sodium alginate. The material is made from the following components by mass percent: 1-35% of carboxymethyl chitosan, 1-25% of oxidized sodium alginate, 0.01-0.5% of nano-silver and distilled water. The material is prepared by the following steps: preparing the carboxymethyl chitosan by a carboxymethylation reaction of chitosan at the temperature of 10-80 DEG C; preparing the oxidized sodium alginate by an oxidation reaction of sodium alginate at the temperature of 10-45 DEG C; respectively preparing aqueous solution of the carboxymethyl chitosan and aqueous solution of the oxidized sodium alginate; adding the nano-silver solution and blending at certain ratio; and allowing self-crosslinking of the components at the temperature of 10-50 DEG C to produce the antibacterial hydrogel material. The antibacterial hydrogel material has the advantages of low cost, environmental protection, simple process and the like; as the carboxymethyl chitosan has good biocompatibility, the oxidized sodium alginate is nontoxic to human body, and the nano-silver has excellent antibacterial property, the obtained material can be applied to wound dressing, hemostatic materials and the like.

Description

technical field [0001] The invention relates to the field of polymer material science, in particular to a carboxymethyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material and a preparation method thereof. Background technique [0002] Carboxymethyl chitosan is a water-soluble derivative of chitosan after carboxymethylation reaction. The introduction of carboxyl group greatly improves the water solubility of chitosan on the one hand, and on the other hand makes it a kind of An amphoteric polymer electrolyte containing a carboxyl group. Compared with chitosan, carboxymethyl chitosan has good water solubility, good biocompatibility and bioadhesion, and can be completely degraded in vivo. The oxidized sodium alginate obtained by oxidizing sodium alginate with sodium periodate has a dialdehyde structure, which can replace the commonly used formaldehyde, glutaraldehyde and other cross-linking agents that are more toxic to the human body. The two a...

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Problems solved by technology

[0003] At present, there are few reports on carboxymethyl chitosan hydrogels at home and abroad, mainly focusing on the preparation of hydrogels with formaldehyde and g