Hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material

Abstract

The invention discloses a self-crosslinking antibacterial hydrogel material containing hydroxypropyl chitosan / oxidized sodium alginate. The material is made from the following components by mass percent: 1-25% of hydroxypropyl chitosan, 1-30% of oxidized sodium alginate, 0.01-0.5% of nano-silver and distilled water. The material is prepared by the following steps: preparing the hydroxypropyl chitosan by a hydroxypropylation reaction of chitosan at the temperature of 10-90 DEG C; preparing the oxidized sodium alginate by an oxidation reaction of sodium alginate at the temperature of 10-45 DEG C; respectively preparing aqueous solution of the hydroxypropyl chitosan and aqueous solution of the oxidized sodium alginate; adding the nano-silver solution and blending at certain ratio; allowing self-crosslinking of the components at the temperature of 10-50 DEG C to produce the antibacterial hydrogel material. The antibacterial hydrogel material has the advantages of low cost, environmental protection, simple process and the like; as the hydroxypropyl chitosan has good biocompatibility, the oxidized sodium alginate is nontoxic to human body, and the nano-silver has excellent antibacterial property, the obtained material can be applied to wound dressing, hemostatic materials and the like.

Description

technical field [0001] The invention relates to the field of polymer material science, in particular to a hydroxypropyl chitosan / oxidized sodium alginate self-crosslinking antibacterial hydrogel material and a preparation method thereof. Background technique [0002] Hydroxypropyl chitosan is the C in the chitosan molecule 6 Another water-soluble derivative obtained by introducing a hydroxypropyl group into a hydroxyl group through an etherification reaction, the introduction of a hydroxypropyl group improves the water solubility of chitosan. Hydroxypropyl chitosan is often made into drug sustained-release materials. At the same time, hydroxypropyl chitosan has good film-forming properties, good biocompatibility, and is non-toxic to organisms, so it is more and more used in the field of medicine. The oxidized sodium alginate obtained by oxidizing sodium alginate with sodium periodate has a dialdehyde structure, which can replace the commonly used formaldehyde, glutaraldehy...

AI Technical Summary

Problems solved by technology

[0003] At present, there are few reports on hydroxypropyl chitosan hydrogel at home and abroad, mainly focusing on the preparation of hydrogels with formaldehyde and glutaraldehyde as cross-linking agents. glue research

However, there is no report on the self-crosslinking antibacterial hydrogel material of hydroxypropyl chitosan / oxidized sodium alginate