36 results about "Toxin types" patented technology

A sinus headache can be treated by administration of a botulinum toxin to a patient. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of a sinus membrane of a patient with a sinus headache.

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

The invention discloses a composition, kit and method for detecting high-virulence bacterial strains and / or toxin type of clostridium difficile. The composition and kit comprise primers, probes and standard substances, wherein the nucleotide sequence of the primers is as shown in SEQ ID NO. 1-47; the high-virulence bacterial strains and / or toxin type of clostridium difficile can be detected through fluorogenic quantitative PCR by adopting the composition or kit. According to the invention, the sensitivity and specificity are high; the toxin type and virulence of clostridium difficile can be accurately judged through detecting tcdC gene mutation or deletion and coordinating with virulence gene detection, including tcd A / B and binary virulence gene cdt A / B, of clostridium difficile.

This invention broadly relates to recombinant DNA technology, molecular biology, neuroscience, and medicine. Particularly, the present invention features novel sequences of the toxin and non-toxin components of the Clostridium botulinum toxin type A-Hall (Allergan) strain complex as well as the expression vector system in a heterologous organism and methods to express such nucleic acid sequences.

Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.

Provided is a method of isolating a botulinum toxin type A macro complex from a botulinum toxin-containing solution, the method including performing anion exchange chromatography and cation exchange chromatography.

The invention discloses a traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection. The traditional Chinese medicine preparation comprises honeysuckle, fructus forsythiae, folium isatidis, mother chrysanthemum, wild buckwheat, semen oroxyli, the root of Chinese pulsatilla, purslane, edible tulip, yellowweed, radix ampelopsis, calculus bovis, eupatorium, mangnolia officinalis, amomum kravanh, immature bitter orange, fevervine, Poria cocos, semen coicis, caulis clematidis armandii, junci medulla, rattletop, gypsum rubrum, bamboo leaf, endive, bark of Indian quassiawood, fimbriate calanthe pseudobulb, dindygulen peperomia herb, Roughhaired Holly Root, natant salvinia herb, pterocephalus hookeri heck, manystem stonecrop leaf and phaenosperma globosa. The traditional Chinese medicine preparation has the effects of clearing away heat and toxic materials and invigorating spleen to eliminate dampness and is mainly used for treating toxin syndromes of recurrent oral ulcer during external infection. By utilizing the theory of traditional Chinese medicine, the overall immunity of the organism is regulated on the basis of the overall concept, the targeting property is high during treatment based on syndrome differentiation, the traditional Chinese medicine preparation has the effects of diminishing inflammation and relieving pain, expansion of the wound surface is avoided, and the drug effect is directly accessed to the lesions. Moreover, the traditional Chinese medicine preparation is safe and effective and difficultly generates drug resistance, and the reoccurrence rate is reduced.

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

The invention discloses a full-automatic toxin extraction and detection integrated instrument. The instrument comprises a mounting box body; a first mounting plate, a transportation supporting plate, a second mounting plate, a control area partition plate, a centrifugal area partition plate, a detection area partition plate and a peristaltic pump mounting plate are arranged in the mounting box body; a conveying mechanism, a mincing station, a liquid adding and taking station and a homogenizing station are mounted on the first mounting plate; a control module for controlling the whole extraction and detection process is arranged in the control area; a centrifugal station for extracting to-be-detected liquid from a mixture of the shellfish samples in the conveying mechanism is arranged in the centrifugal area; and a detection station for detecting the type and concentration of toxins in the to-be-detected liquid extracted by the centrifugal station is arranged in the detection area. The full-automatic toxin extraction and detection integrated instrument fully automatically completes mincing, extraction, homogenization, centrifugation, filtration and detection of shellfish samples, has a certain self-cleaning function, is simple and convenient to operate, and is suitable for on-site rapid detection.

Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.

The invention discloses triplex PCR detection primers and a triplex PCR detection kit for cytolethal distending toxins A, B and C of Campylobacter. The Campylobacter involved in the invention comprises Campylobacter coli, Campylobacter jejuni and Campylobacter fitus, and the nucleotide sequences of corresponding primers thereof are as shown in SEQ ID No. 1 to SEQ ID No. 18. A triplex PCR detectionmethod provided by the invention can quickly and accurately detect the cytolethal distending toxins of Campylobacter, and can realize detection of a single toxin or all the three toxins selected fromthe cytolethal distending toxins A, B and C of Campylobacter in one operation, so time and effort are saved, and the detection can be completed in on shot without three PCR operations and three electrophoresis operations; a conventional single PCR method usually takes 2-3 days, and the triplex PCR detection method of the invention shortens detection time to 4 h, so work efficiency is greatly improved; and the method can be used for general investigation of the toxin types of Campylobacter, molecular epidemiological investigation and vaccine screening and detection.

The invention relates to an oral liquid for treating pyretic periodontitis. The oral liquid is made of the following raw materials in parts by weight: 4-13 parts of sodium deoxycholate, 2-9 parts of tetracycline, and 5-11 parts of metronidazole powder 3-7 parts of minocycline hydrochloride, 6-10 parts of mountain bean root, 3-14 parts of nutmeg, 1-6 parts of Bupleurum, 1-4 parts of gypsum, 4-10 parts of tangerine peel, 3-3 catechu 12 parts, appropriate amount of water; the oral liquid prepared by the present invention makes up for the inconspicuous antibacterial effect and limited effect of treating periodontitis in the existing traditional Chinese medicine composition for treating periodontitis.

Disclosed is a medicinal broth for treating toxic heat type children's bronchial asthma and process for preparation, wherein the medicament is prepared from the following raw materials (by weight portion): plaster stone 12-15g, radish seeds, purple perilla seed, mulberry bark, radix adenophorae, dried rehmannia root each 8-10g, white mustard seed, and baikal skullcap root each 5-7g.

The invention discloses a traditional Chinese medicine composition for treating yin-deficiency heat toxin type radiation-induced salivary gland damage. According to the traditional Chinese medicine, radiotherapy rays are heat toxins, and symptoms such as heat toxin-induced body fluid impairment and yin and body fluid deficiency can be caused after radiotherapy. Therefore, traditional Chinese medicines such as Chinese Ladiestresses Root or Herb, bornet cowlily rhizome, membrane of hen egg, dunn antiotrema root, Antidesma bunius, Goldhair Hedyotis Herb, trollflower, endive, Canscora lucidissima, crataeva leaf, Hypericum ascyron and cephalanoplos setosum with the effects of nourishing yin and clearing heat and detoxifying and activating blood circulation are selected to be decocted into decoction by adding water. The clinical test proves that saliva flow velocity, amylase secretion rate and increase of secretion rate of the parotid gland and salivary gland in a treatment group are superior to those in a control group, and the living quality of patients is obviously improved.

The invention discloses an external traditional Chinese medicine for treating heat toxin type acne. The external traditional Chinese medicine is composed of the following raw materials in parts by weight: 15-20 parts of dandelion, 20-25 parts of honeysuckle, 4-6 parts of perilla leaf, 5-7 parts of radix polygonati officinalis, 2-4 parts of radix angelicae, 4-5 parts of calamine, 8-10 parts of cimicifugae foetidae, 4-6 parts of wine fried rhubarb, 2-4 parts of herba violae, 5-6 parts of radix bupleuri, 8-10 parts of saposhnicovia divaricata, 3-5 parts of sesame leaf, 2-4 parts of crinis carbonisatus, 5-8 parts of dogwood, 4-5 parts of concha arcae, 2-4 parts of caulis spatholobi, 1-3 parts of hippuris vulgaris, 2-4 parts of conocephalum conicum(L.) dumort, 5-8 parts of polycarpae and 4-5 parts of coninshaped blueberry branchlet and leaf. The medicines are cooperatively in the external traditional Chinese medicine disclosed by the invention to ensure the functions of clearing away heat and drying dampness, clearing and activating the channels and collaterals, clearing heat and cooling blood, resolving hard lumps, promoting blood circulation to remove blood stasis, relieving swelling and pain, expelling noxious substance and pus, and removing the necrotic tissue and promoting granulation; the saposhnicovia divaricata has the function of dispelling wind to relieve exogenous syndromes, the honeysuckle and the dandelion have the functions of clearing away heat and toxic materials, preventing inflammation, tonifying deficiency and treating wind, the radix angelicae has the functions of eliminating dampness, relieving pain, relieving swelling and expelling pus, the radix polygonati officinalis and the radix bupleuri have the functions of promoting blood circulation and stopping pain, diminishing swelling and promoting granulation, and the radix clematidis has the function of stimulating the circulation of the blood and causing the muscles and joints to relax. The external traditional Chinese medicine disclosed by the invention is short in cure time, obvious in curative effect, safe and reliable and free of toxic and side effects.

The present invention relates to a botulinum toxin type A complex, and a formulation thereof and a usage method therefor. The present invention provides the botulinum toxin type A complex, comprising an HA70 component, and an HA17 component, an HA33 component, an NTNH component, and a BoNT / A1 component, wherein the botulinum toxin complex has a molecular weight of 740-790 kDa. Compared with the existing botulinum toxin complexes, the botulinum toxin complex of the present invention is smaller in molecular weight and higher in safety, and has a comparable treatment effect.

The invention relates to clostridium perfringens in excrement as a molecular marker for grading and judging fatty liver diseases related to metabolic dysfunction and application of the clostridium perfringens, the clostridium perfringens contains alpha toxin CPA according to the types of main toxins generated by the clostridium perfringens, the coding gene of the alpha toxin CPA is plc gene, and the content of the alpha toxin CPA is determined by quantitatively detecting the plc gene. The molecular level detection of the clostridium perfringens in the excrement sample is realized; besides, the clostridium perfringens further contain nirA genes related to nitrogen metabolism, the nirA genes participate in the metabolic process related to microbial ammonia production, the functional state of the intestinal ammonia-producing microorganisms is reflected by detecting the expression level of the nirA genes, stable acquisition of the molecular characteristics of the intestinal microorganisms related to the MASLD is achieved, and the application prospect is broad. A molecular basis is provided for analyzing the correlation between the abnormal ammonia metabolism and the occurrence and development of the MASLD.

The invention discloses application lotion for preventing and controlling wind-heat toxin type herpes simplex and belongs to the technical field of health care products. The application lotion is mainly composed of eight raw medicinal materials such as isatis roots, jasmine, magnolia flowers, tasteless preserved soybeans, turmeric and the like, and is prepared into liquid medicine for external application. The application lotion disclosed by the invention has the effects of clearing heat and removing toxins, dispelling wind and clearing heat, has an excellent effect of preventing and controlling wind-heat toxin type herpes simplex and is convenient to apply, safe and effective.

The invention discloses edible medicinal paste for preventing and treating infective pathogenic toxin type acute pelvic inflammatory disease, and belongs to the technical field of health care drinks.Ten kinds of bulk drugs, such as herba violae, isatis root, Sichuan lovage rhizome, cape jasmine fruit and motherwort herb, are mainly prepared into the medical paste for eating. The medical paste hasfunctions of eliminating pathogenic heat from the blood, detoxicating and reducing inflammation, and has good effects on preventing and treating infective pathogenic toxin type acute pelvic inflammatory disease; and the medical paste is convenient for eating, safe and effective.

A Chinese medicine in the form of decoction for treating the excessive heat toxin type aplastic anemia is prepared from 13 Chinese-medicinal materials including astragalus root, rehmannia root, fleece flower root, pilose asiabell root, etc. Its preparing process is also disclosed.

The invention discloses raspberry leaf black tea and a preparation method thereof. The raspberry leaf black tea comprises raspberry leaves, raspberries, hyssop and lemon grass, and the weight ratio of the raspberry leaves to the raspberries to the hyssop to the lemon grass is 4: 4: 3: 6. According to the raspberry leaf black tea for treating stasis toxin type colitis and the preparation method of the raspberry leaf black tea, the hyssop and the lemon grass for promoting absorption are matched, the effect of the raspberry leaves can be fully exerted, ellagic acid contained in the raspberry leaves has a relatively strong inhibition effect on staphylococcus aureus, vibrio cholerae and the like, and the effect of treating stasis toxin type colitis is achieved. The human body immunity can be obviously improved; the waste raspberry leaves are reasonably processed through a scientific and effective method, effective components such as ellagic acid are preserved to a large extent, agricultural ecological resources are activated and protected while the use value of the raspberry leaves is fully explored, and the method has important significance on resource production of raspberry wastes.

The invention discloses a traditional Chinese medicine formula for treating stasis toxin type colitis and a preparation method thereof. The traditional Chinese medicine formula for treating stasis toxin type colitis is prepared from the following raw materials by weight: 16-23 g of safflower, 28-35 g of radix aconiti agrestis, 28-35 g of coptis chinensis, 16-20 g of akebia stem, 16-20 g of sargentgloryvine stem, 10-13 g of berba aristolochiae mollissimae and 4-6 g of nail polish powder. The traditional Chinese medicine composition has the advantages of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, eliminating dampness and removing food stagnation, tonifying qi and warming the kidney by warming and nourishing the spleen and the kidney and aiming at the symptoms of spleen weakness, kidney deficiency and blood stasis toxin accumulation, and can achieve the purpose of colon nursing.

An interior-applied Chinese medicine for treating the heat toxin-type cold is proportionally prepared from notopterygium root, dandelion herb and isatis root.

The present application relates to a kind of toxin type plant rooting liquid, rooting method and application, wherein the composition of rooting liquid is poplar canker bacteria toxin, formula is 5.00% poplar canker bacteria toxin aqueous solution, using method is the base of the stem section to be rooted into the rooting liquid, when the stem section base appears root primordium, transplant to soil, rooting rate can reach 83.33%, and more fibrous root, plant growth is robust, seedling survival rate can reach 83.33%, simultaneously, the rooting liquid has the ability of enhancing seedling disease resistance simultaneously.This application not only can efficiently promote plant rooting, improve transplanting survival rate, but also can improve the immunity of plant, low cost, simple to make, convenient to use, remarkable effect.

The invention discloses vinegar liquid for preventing and treating infective pathogenic toxin type acute pelvic inflammatory disease, and belongs to the technical field of health care drinks. Ten kinds of bulk drugs, such as herba violae, isatis root, Sichuan lovage rhizome, cape jasmine fruit and motherwort herb, are mainly prepared into the medical vinegar for taking. The vinegar liquid has functions of eliminating pathogenic heat from the blood, detoxicating and reducing inflammation, and has good effects on preventing and treating infective pathogenic toxin type acute pelvic inflammatory disease; and the vinegar liquid is easy to take, safe and effective.

The invention relates to a toxin type plant rooting solution, a rooting method and application, the rooting solution comprises poplar canker toxin and 5.00% poplar canker toxin aqueous solution. The use method is as follows: inserting the basal part of a to-be-grown rhizome section into the rooting solution, and transplanting into soil when a root primordium appears at the basal part of the stem section. The rooting rate can reach 83.33%, more fibrous roots are generated and the plant is robust, and the survival rate of seedlings can reach 83.33%; meanwhile, the rooting medium has the capacity of enhancing the disease resistance of the seedlings. The plant rooting solution can efficiently promote plant rooting, improve the transplanting survival rate and improve the immunity of plants, and is low in cost, easy to manufacture, convenient to use and remarkable in effect.

The invention provides a technology for detecting toxins such as swill-cooked dirty oil and chemicals in meals through knives and forks and performing voice warning, thereby solving a catering safetyaccident problem that the toxins such as swill-cooked dirty oil and chemicals in meals can not be detected timely to cause personal injuries even life safety threat. According to the invention, knivesand forks that are provided with various potential food safety hazard intelligent detection chips are used for carrying out toxin voice warning on toxins in current meals of diners. Toxin detection points at tail ends of knives and forks are in contact with various dishes or staple foods to analyze components; the detected component data are transmitted to an intelligent analysis system for toxins such as illegal cooking oil, chemicals and the like in knives and forks; toxin type analysis and comparison are carried out on the measured component data; and thus the meal toxins are determined tobe swill-cooked dirty oil, chemicals or other toxins.

Disclosed is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically disclosed are multiple human anti-botulinus toxin type-A antibodies having different epitopes from one another. Also specifically disclosed is a composition for neutralizing botulinus toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.

The invention discloses a suppository for preventing and treating an infected pathogenic toxin type acute pelvic inflammatory disease and belongs to the technical field of health-care products. The suppository is mainly prepared from 10 medicinal raw materials such as coptis chinensis, the root bark of the peony tree, salvia miltiorrhiza, the rhizome of chuanxiong and frankincense and is used forexternal application. The suppository has the functions of clearing away heat, cooling blood, removing toxin and diminishing inflammation, has the good effect of treating the infected pathogenic toxintype acute pelvic inflammatory disease and is convenient to use, safe and effective.

The invention relates to the technical field of aquatic product quality safety, in particular to a saxitoxin risk formation chain characterization monitoring system, which comprises a data acquisition module, a data processing module, a data processing module and a display module, the risk chain association module is used for constructing a multi-factor toxin association mechanism model, analyzing and quantifying influence weights of environmental factors through a causal inference algorithm and a random forest weight, and identifying key regulation points and threshold values of toxin synthesis; the risk chain mechanism analysis module carries out deduction through a digital twin simulation platform and a dynamic Bayesian network, simulates the dynamic change of a toxin anabolism pathway under different environment scenes, and obtains a risk formation chain and a risk change rule thereof; and the risk monitoring and intervention module constructs a global risk prediction model to obtain a risk level, obtains an emergency scheme from the emergency decision library according to the risk level and the toxin type, and performs intervention according to the emergency scheme. Therefore, the problems of monitoring lag, unknown causality, low intervention efficiency and the like are solved.