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Minocycline hydrochloride sustained release tablet and preparation method thereof

A technology of minocycline hydrochloride and sustained-release tablets, which is applied to tetracycline active ingredients, pharmaceutical formulations, pill delivery, etc., to achieve the effects of increasing stability, reducing production costs, and shortening the production cycle

Inactive Publication Date: 2012-11-14
SICHUAN BAILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These important observations suggest that weight-based dosing may be beneficial, and that rapid absorption and high plasma levels at initiation of treatment may be responsible for clinically acute vestibular adverse events

Method used

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  • Minocycline hydrochloride sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: a kind of minocycline hydrochloride slow-release tablet, its prescription is as follows:

[0054] Minocycline hydrochloride 45.0g (as minocycline)

[0055] Hypromellose (E50LV) 95.0g

[0056] Lactose 230.0g

[0057] Silica 5.0g

[0058] Magnesium Stearate 3.5g

[0059] Coating prescription:

[0060] Gastric film coating premix 7.8g

[0061] Purified water 70.2ml

[0062] Preparation Process:

[0063] (1) Pass the minocycline hydrochloride through a 100-mesh sieve, pass the auxiliary materials through a 80-mesh sieve, and set aside.

[0064] (2) Weigh the prescribed amount of minocycline hydrochloride, hypromellose (E50LV), and lactose, mix well, and dry-press the granules with a dry granulator (extrusion speed: 20r / min; pressure: 3.0MPa) , Sieve the 16-30 mesh particles, and add the sifted fine powder to the granulation cycle.

[0065] (3) Add the prescribed amount of silicon dioxide and magnesium stearate, mix well, and press plain tablets.

[0...

Embodiment 2

[0068] Embodiment 2: a kind of minocycline hydrochloride sustained-release tablet, its prescription is as follows:

[0069] Minocycline hydrochloride 45.0g (as minocycline)

[0070] Hypromellose (E50LV) 95.0g

[0071] Mannitol 230.0g

[0072] Silica 5.0g

[0073] Magnesium Stearate 3.5g

[0074] Coating prescription:

[0075] Gastric film coating premix 7.8g

[0076] Purified water 70.2ml

[0077] Preparation Process:

[0078] (1) Pass the minocycline hydrochloride through a 100-mesh sieve, pass the auxiliary materials through a 80-mesh sieve, and set aside.

[0079] (2) Weigh the prescribed amount of minocycline hydrochloride, hypromellose (E50LV), and mannitol, mix well, and dry-press the granules with a dry granulator (extrusion speed: 20r / min; pressure: 3.0MPa ), sieve 16-30 mesh granules, and the sieved fine powder is added to the granulation cycle.

[0080] (3) Add the prescribed amount of silicon dioxide and magnesium stearate, mix well, and press plain tablets...

Embodiment 3

[0083] Embodiment 3: a kind of minocycline hydrochloride slow-release tablet, its prescription is as follows:

[0084] Minocycline hydrochloride 45.0g (as minocycline)

[0085] Hypromellose (E50LV) 95.0g

[0086] Lactose 230.0g

[0087] Silica 5.0g

[0088] Magnesium Stearate 3.5g

[0089] Coating prescription:

[0090] Gastric film coating premix 7.8g

[0091] Purified water 70.2ml

[0092] Preparation Process:

[0093] (1) Pass the minocycline hydrochloride through a 100-mesh sieve, pass the auxiliary materials through a 80-mesh sieve, and set aside.

[0094] (2) Weigh the prescribed amount of minocycline hydrochloride, hypromellose (E50LV), and lactose, mix well, and dry-press the granules with a dry granulator (extrusion speed: 20r / min; pressure: 2.5MPa) , Sieve the 16-30 mesh particles, and add the sifted fine powder to the granulation cycle.

[0095] (3) Add the prescribed amount of silicon dioxide and magnesium stearate, mix well, and press plain tablets.

[0...

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Abstract

The invention discloses a minocycline hydrochloride sustained release tablet which is prepared from the following components in parts by weight: 40-90 parts of hydrochloride sustained release tablet, 80-120 parts of hydroxypropyl methylcellulose, 200-260 parts of lactose, 3-8 parts of silicon dioxide, 2-6 parts of magnesium stearate and 4-10 parts of coating materials. The invention also discloses a preparation method of the sustained release tablet. According to the minocycline hydrochloride sustained release tablet disclosed by the invention, the known unhealthy acute vestibule events caused by minocyline can be reduced, the tablet is released stably; and the preparation method has the advantages that the concept is ingenious, the flow is simple, the process is stable, the operation is simple and convenient, the production period is short, the product yield and the product stability are increased, and the production cost is lowered.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy, and relates to a minocycline hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Acne vulgaris is a chronic inflammatory skin disease of the sebaceous glands. The incidence of acne among adolescents aged 12-24 is as high as 85%. Most males develop acne at the age of 14-19, and females mostly develop acne at the age of 10-17, and most of them before the age of 25. Healed, only a few last until age 45 and beyond. Acne is not only a physical disease, but its social, psychological, and emotional impact on patients is no less than that of severe asthma, epilepsy, diabetes, low back pain, arthritis and other diseases. Therefore, acne is a disease that cannot be ignored. psychosomatic disease. [0003] Because the inflammatory skin lesions of acne - papules, pustules, nodules or cysts are related to the abnormal keratinization of the piloseb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/65A61K47/38A61P17/10
Inventor 王一茜廖彬
Owner SICHUAN BAILI PHARM CO LTD
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