Minocycline hydrochloride microballoons and preparation method and application in pharmacy thereof
A technology of minocycline hydrochloride and microspheres, which is applied in the directions of active ingredients of tetracycline, drug combination, digestive system, etc. It can solve the problems of heavy burden on patients and high listing price, and achieve lower listing price, reduce patient burden, and reduce costs Effect
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Embodiment 1
[0026] Take 3 mL of 40% polylactic acid (PLA) solution, add 0.3 g of minocycline hydrochloride, and continue heating to dissolve it. Transfer the above polylactic acid solution to a flask, add 60mL of liquid paraffin preheated to 50°C and an appropriate amount of Span 65 and Tween 80, stir and emulsify at a constant temperature for 35 minutes, quickly cool it to 0°C-5°C, add vanillin Use 1mol / L sodium hydroxide to adjust the pH value to 8-9, stir in an ice-water bath for 4 hours, pour off the paraffin on the surface after it is fully solidified, filter it with suction, and wash it with acetone for 2-3 times until there is no vanillin smell , to obtain a yellow powdery solid. Take 1.0g of methylcellulose, add appropriate amount of purified water to fully swell, take another appropriate amount of purified water, dissolve propylene glycol and glycerin, and mix with the above methylcellulose solution evenly, add sodium hydroxide solution while stirring to make it into a gel Gel b...
Embodiment 2
[0028] Take 3 mL of 35% polylactic acid (PLA) solution, add 0.2 g of minocycline hydrochloride, and continue heating to dissolve it. Transfer the above polylactic acid solution to a flask, add 50mL of preheated peanut oil and an appropriate amount of Span 65 and Tween 80, stir and emulsify at a constant temperature for 30 minutes, then quickly cool it to 0°C-5°C, add 18mL of paraformaldehyde solution, Adjust the pH value to 8-9 with 1mol / L sodium hydroxide, stir in an ice-water bath for 4 hours, pour off the peanut oil on the surface after it is fully solidified, filter with suction, wash with acetone for 2-3 times until there is no paraformaldehyde smell, and obtain Yellow powdery solid.
Embodiment 3
[0030] Take 3 mL of 30% gelatin solution, add 0.2 g of minocycline hydrochloride, and continue heating to dissolve it. Transfer the above gelatin solution to a flask, add 45mL of preheated soybean oil and an appropriate amount of Span 80, stir and emulsify at a constant temperature for 30 minutes, then quickly cool it to 0°C-5°C, add 15mL of formaldehyde, and use 1mol / L hydrogen Adjust the pH value to 8-9 with sodium oxide, stir in an ice-water bath for 4 hours, pour off the surface soybean oil after it is fully solidified, filter with suction, wash with acetone 2-3 times until there is no formaldehyde smell, and obtain a yellow powdery solid.
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