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Controlled ointment compound stroma and the preparing method

A technology of ointment and matrix, which is applied in the field of medicine and can solve problems such as cumbersome production processes

Inactive Publication Date: 2007-09-26
北京恩泽美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The preparation process of cyclodextrin inclusion compound is divided into grinding method, solvent evaporation method, freeze-drying method, spray drying method and ultrasonic method. Among them, the grinding method mainly uses water as the grinding medium, and after grinding, it needs elution, drying and other processes. The process is more cumbersome

Method used

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  • Controlled ointment compound stroma and the preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Grind 5g of chlorhexidine acetate and 15g of glycerin in a mortar for 5 minutes. After grinding evenly, add 30g of β-cyclodextrin and grind them together for 15 minutes to obtain clathrates. At this time, 5g of glycerol triacetate and 26g Diethyl phthalate plasticizer was mixed and heated at 150°C for 15 minutes to melt the mixture of 14g ethyl cellulose and 5g RSPO into the clathrate and grind together for 30 minutes to obtain a controlled release ointment base.

Embodiment 2

[0035] Grind 5g of metronidazole and 5g of glycerin in a mortar for 5 minutes, and after grinding evenly, add 5g of β-cyclodextrin into it and grind for 15 minutes to obtain an inclusion compound. At this time, 5g of triacetin and 40g of Diethyl phthalate plasticizer was mixed and heated at 150° C. for 15 minutes to melt 40 g of ethyl cellulose, added to the clathrate and co-ground for 90 minutes to prepare a controlled-release ointment base.

Embodiment 3

[0037] Grind 5g of metronidazole and 15g of glycerin in a mortar for 5 minutes, and after grinding evenly, add 25g of 2,3-diacetyl-β-cyclodextrin into it and grind together for 15 minutes to obtain an inclusion compound. 7g glyceryl triacetate was mixed with 30g dibutyl phthalate plasticizer and heated at 150°C for 15 minutes to melt, and 18g ethyl cellulose was added to the clathrate and ground together for 60 minutes to obtain a controlled release ointment matrix.

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Abstract

The invention relates to a method for preparing control-release paste medium, comprising cyclodextrin, drug, macromolecule and elasticizer. The invention uses package and macromolecule mixing technique to prepare the control-release paste medium with needed rigidity and rheological property. The invention is characterized in that it uses insoluble cellulose ethyl ether and low-permeability acrylic resin mixture medium as the skeleton control-release material, and uses cyclodextrin and ealsticizer to adjust the rheological property and drug release speed of the paste, uses glycerin and drug grind method to pack the drug. Via external release degree test, the paste which contains Minocycline Hydrochloride, polycyclic acid or the like, via slurry method (at 37Deg. C, 100rpm) can reach 20-40% in 1h, 40-60% in 3h, 50-80% in 7h, and 80-90% in 12h. The inventive paste can be used to treat mouth and vaginal diseases.

Description

technical field [0001] The invention relates to preparation technology in the field of medicine. Background technique [0002] Oral and vaginal mucosal administration can avoid the first-pass effect of the drug on the liver and improve the bioavailability of the drug. In addition, it can maintain the effective concentration of the local drug for a long time in the treatment of oral and vaginal local diseases, reducing the dosage and frequency of administration , reduce side effects and improve patient compliance. However, film, suppository and gel are the majority of oral and vaginal mucosal administration dosage forms, and these dosage forms often have disadvantages such as inconvenient administration, foreign body sensation and frequent administration times due to their certain physical form and easy rapid erosion. , limiting its further application. [0003] At present, there are many reports on the inclusion of fat-soluble drugs by cyclodextrin to improve drug solubili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K9/06A61K31/155A61K31/4164A61K31/65A61K31/7056A61P31/04A61P31/10A61P1/02A61P15/02
Inventor 汪晴柳伟
Owner 北京恩泽美科技有限公司
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