Xerostomia gel film and preparation method thereof

A dry mouth and gel film technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of artificial saliva, oral moisturisers and lubricants that only have a moisturizing function and have no other medical effects. , to achieve the effect of promoting the growth of beneficial bacteria, preventing tooth loss, and improving clinical efficacy

Inactive Publication Date: 2018-12-04
FOSHAN SENANG BIO TECH CO LTD
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Problems solved by technology

[0006] Technical problem to be solved by the present invention: Although there are many kinds of saliva substitutes for relieving oral symptoms on the market, artific...

Method used

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  • Xerostomia gel film and preparation method thereof

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Embodiment Construction

[0021] Take 10-20g Polygonatum Polygonatum, 10-20g Paeoniae Alba, 10-20g Black Plum, 10-20g Dihuang, 6-12g Chinese Yam, 12-24g Ophiopogon japonicus, 12-24g Scrophulariaceae, 20-40g Astragalus, 10-20g Honeysuckle, Add 8-16g of mountain bean root into 500-600g of ethanol solution with a mass fraction of 50%, and use 200W microwave to assist extraction for 10-15min, then transfer it to a centrifuge, and centrifuge at 4000-5000r / min for 15-20min to obtain traditional Chinese medicine Extract solution, put the traditional Chinese medicine extract solution into a rotary evaporator and concentrate under reduced pressure to a density of 1.1-1.2 to obtain a concentrated solution, mix the concentrated solution with a 50% ethanol solution at a mass ratio of 1:5-1:10, and statically Set aside for 10-20 hours and then filter to obtain the filtrate. Concentrate the filtrate under reduced pressure to a density of 1.25-1.30 to obtain a traditional Chinese medicine extract. Take 0.5-1.0 g of gl...

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Abstract

The invention relates to a xerostomia gel film and a preparation method thereof, and belongs to the technical field of medicinal materials. By the combination of traditional Chinese medicines and minocycline hydrochloride and with the compatibility of medicines such as radix scrophulariae, radix rehmanniae, dark plum, polyghace seche, Radix Ophiopogonis and the like, the good effects of cooling the blood and clearing heat, promoting the production of body fluid to quench thirst and tonifying Qi and nourishing yin can be achieved, patient's condition is effectively improved, the amount of saliva secretion is increased, and pathogenic bacteria are reduced. Thereby, loss of tooth and gum diseases are prevented, natural infection resistance of the body can be enhanced, and special pathogenic bacteria can be specifically targeted to be killed. The chitosan can help protect mouth mucosa and teeth and reduce acidity of tooth surface, help keep a good pH value, assist the natural healing mechanism of the oral cavity, relieve xerostomia symptom and affect and inhibit bad breath, tooth decay and oral diseases, form high concentration in local parts to play the antibacterial action, achieve the effects of diminishing inflammation, promoting tissue regeneration and promoting dental care and raise the clinical efficacy.

Description

technical field [0001] The invention relates to a xerostomia gel film and a preparation method thereof, belonging to the technical field of medicinal materials. Background technique [0002] Dry mouth is an objective manifestation, which indicates that the secretion of saliva in the oral cavity decreases or the consumption increases due to various reasons, and a negative balance of saliva secretion and consumption occurs in the oral cavity, causing dry mouth. Xerostomia is the main complaint of dry mouth, which is a symptom of subjective feeling. It is the subjective feeling caused by the objective dry mouth stimulation reaching a certain threshold. The sensation of xerostomia (xerostomia) is not always accompanied by objective dry mouth. With the improvement of people's quality of life and the enhancement of self-care awareness, more and more patients seek medical treatment with xerostomia, accounting for about 10% of the population; among the elderly over 65 years old, mo...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K36/8968A61P1/02A61K31/65
CPCA61K9/006A61K31/65A61K36/355A61K36/481A61K36/489A61K36/65A61K36/71A61K36/736A61K36/804A61K36/808A61K36/8945A61K36/8968A61K36/8969A61K47/38A61K2236/333A61K2236/51A61P1/02A61K2300/00
Inventor 胡次兵张桂芳史志新
Owner FOSHAN SENANG BIO TECH CO LTD
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